Respiratory Syncytial Virus Burden in Premature Infants: The Role of Season With and Without RSV Immunoprophylaxis in a Multicenter Study. [PDF]
ABSTRACT Objective To compare the Respiratory Syncytial Virus (RSV) hospitalization burden among 29–34 weeks gestational age (wGA) preterm infants between seasons with and without routine palivizumab prophylaxis, by utilizing the 2021 off‐season RSV surge.
Domany KA+18 more
europepmc +2 more sources
Respiratory Syncytial Virus Incidence in Young Children in the United States: Impact of Methodologies and Patient Characteristics. [PDF]
ABSTRACT Objectives This study aimed to estimate the incidence of respiratory syncytial virus (RSV) infections in US inpatient and outpatient settings. Methods We established national cohorts of privately insured children < 5 years (2011–2019) to estimate annual and seasonal incidences of lower respiratory tract infection (LRTI), RSV‐LRTI, and RSV ...
Nduaguba SO+6 more
europepmc +2 more sources
An Improved Rapid and Sensitive Long Amplicon Method for Nanopore-Based RSV Whole-Genome Sequencing. [PDF]
ABSTRACT Background Whole‐genome sequencing (WGS) provides critical insights into the respiratory syncytial virus (RSV) transmission and any emerging mutations that could impair the efficacy of monoclonal antibodies or vaccines that have been recently licenced for clinical use worldwide.
Dong X+10 more
europepmc +2 more sources
Safety and Effectiveness of Palivizumab in Children at High Risk of Serious Disease Due to Respiratory Syncytial Virus Infection: A Systematic Review [PDF]
Caroline Park+7 more
exaly +2 more sources
The Medicaid Cost of Palivizumab [PDF]
To the editor—Borse et al. [1] describe an economic analysis of respiratory syncytial virus (RSV) prophylaxis for infants in Alaska's Yukon-Kuskokwim Delta. The authors should be congratulated for evaluating this important question with a robust analysis. As these infants are almost entirely insured by Medicaid, we wish to clarify the net Medicaid cost
Kimmie K. McLaurin+1 more
openaire +2 more sources
Risk factors for hospital admission with RSV bronchiolitis in England: a population-based birth cohort study. [PDF]
OBJECTIVE: To examine the timing and duration of RSV bronchiolitis hospital admission among term and preterm infants in England and to identify risk factors for bronchiolitis admission.
A Bottle+35 more
core +6 more sources
Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases [PDF]
For two centuries, vaccination has been the dominating approach to develop prophylaxis against viral infections through immunological prevention. However, vaccines are not always possible to make, are ineffective for many viral infections, and also carry
Fang, Fang, Le Calvez, Hervé, Yu, Mang
core +3 more sources
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state [PDF]
Human respiratory syncytial virus (RSV) is the main cause of lower respiratory tract infections in young children. The RSV fusion protein (F) is highly conserved and is the only viral membrane protein that is essential for infection.
Chen, Man+13 more
core +2 more sources
Epidemiology and potential preventative measures for viral infections in children with malignancy and those undergoing hematopoietic cell transplantation. [PDF]
In pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades.
Alexander, Sarah+5 more
core +1 more source
Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort [PDF]
BACKGROUND: Respiratory Syncytial Virus (RSV) is one of the main causes of respiratory infections during the first year of life. Very premature infants may contract more severe diseases and 'late preterm infants' may also be more susceptible to the ...
Adorni F+60 more
core +1 more source