Results 31 to 40 of about 5,796 (217)

Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study

Frontiers in Pharmacology, 2020
ObjectiveCurrent prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV ...
Anushi E. Rajapaksa, Anushi E. Rajapaksa, Anushi E. Rajapaksa, Lien Anh Ha Do, Lien Anh Ha Do, Darren Suryawijaya Ong, Darren Suryawijaya Ong, Magdy Sourial, Duncan Veysey, Richard Beare, Richard Beare, William Hughes, William Yang, Robert J. Bischof, Robert J. Bischof, Amarin McDonnell, Peter Eu, Leslie Y. Yeo, Paul V. Licciardi, Paul V. Licciardi, Edward K. Mulholland, Edward K. Mulholland, Edward K. Mulholland   +22 more
doaj   +1 more source

Universal palivizumab prophylaxis for children with Down syndrome in Japan: analysis with interrupted time-series

Human Vaccines & Immunotherapeutics, 2021
Down syndrome (DS) is an independent risk factor for severe respiratory syncytial virus (RSV) infection. Palivizumab – passive immunization for RSV – is the only pharmacological measure for preventing severe disease.
Masato Takeuchi, Koji Kawakami
doaj   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Predictive Value of Modified Lung Ultrasound Score for Late Respiratory Diseases in Premature Infants: A Retrospective Cohort Analysis

Journal of Clinical Ultrasound, EarlyView.
This study is to assess the predictive value of the modified lung ultrasound score (mLUS) for late respiratory diseases in premature infants born before 32 weeks of gestation. It is recommended that the use of mLUS scoring be promoted in clinical practice for the early screening of high‐risk preterm infants.
Shuang Zheng, Yang Zhang, Yanan Gao, Huifen Chen, Sudan Liu   +4 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

The influence of respiratory syncytial virus immunoprophylaxis on allergic sensitisation in children with respiratory allergy

Journal of Microbiology, Immunology and Infection
Background: Respiratory syncytial virus (RSV) infection may induce asthma and allergic sensitisation. RSV immunoprophylaxis can reduce the severity of RSV infections. However, the effects of RSV immunoprophylaxis on allergic sensitisation remains unclear.
Li-Ching Fang, Jen-Yu Wang
doaj   +1 more source

Healthcare Utilization in Children Following Hospitalization for RSV‐ Versus Non‐RSV Related Lower Respiratory Tract Infections: A Nationwide Retrospective Study

Pediatric Pulmonology, Volume 61, Issue 1, January 2026.
ABSTRACT Introduction Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections (LRTIs) in young children. Additionally, RSV is associated with long‐term respiratory morbidities. This study evaluates acute and long‐term healthcare utilization (HCU) in infants hospitalized with RSV‐associated LRTI (RSV‐LRTI) compared to ...
Guy Hazan, Mai Ofri, Lital Hertz, Oliver Martyn, David Greenberg   +4 more
wiley   +1 more source

Incidence of respiratory syncytial virus infection in children with congenital heart disease undergoing immunoprophylaxis with palivizumab in Pará state, north region of Brazil

BMC Pediatrics, 2019
Background Palivizumab prophylaxis for the human respiratory syncytial virus (HRSV) has been reported to reduce the risk of hospital admissions related to HRSV in children with congenital heart disease (CHD). These children are at high risk of developing
Roseane Porfírio de Souza, Andre Luis Ribeiro Ribeiro, Sílvio Augusto Fernandes de Menezes, Luiz Fernando Almeida Machado   +3 more
doaj   +1 more source

Bridging Genomics and Clinical Medicine: RSVrecon Enhances RSV Surveillance With Automated Genotyping and Clinically Important Mutation Reporting

Influenza and Other Respiratory Viruses, Volume 20, Issue 1, January 2026.
ABSTRACT Background Respiratory Syncytial Virus (RSV) causes significant respiratory infections, particularly in young children and elderly adults. Genetic variations in the fusion (F) protein can reduce the efficacy of vaccination and monoclonal antibody treatments, emphasizing the need for genomic surveillance of this virus.
Lei Li, Haidong Yi, Jessica N. Brazelton, Richard J. Webby, Randall T. Hayden, Gang Wu, Diego R. Hijano   +6 more
wiley   +1 more source

Spatial and temporal variability of respiratory syncytial virus disease seasonality in Japan, 2012–2024

Pediatrics International, Volume 68, Issue 1, January/December 2026.
Abstract Background Understanding infectious disease seasonality is crucial to inform immunization timing and risk communications. This study aimed to describe trends in respiratory syncytial virus (RSV) seasonality in Japan by determining thresholds across 47 prefectures using public health surveillance data. Methods Weekly RSV cases per sentinel (CPS)
Takeshi Arashiro, Ichiro Morioka, Naruhiko Ishiwada, Oliver Martyn, Rolf Kramer, Jing Jin, Amanda Pinho, Ewen Corbelon, Satoshi Kusuda   +8 more
wiley   +1 more source