Results 41 to 50 of about 9,015 (261)

Likelihood reweighting methods to reduce potential bias in noninferiority trials which rely on historical data to make inference

, 2013
It is generally believed that bias is minimized in well-controlled randomized clinical trials. However, bias can arise in active controlled noninferiority trials because the inference relies on a previously estimated effect size obtained from a ...
Chu, Jianxiong, Nie, Lei, Rubin, Daniel, Zhang, Zhiwei   +3 more
core   +1 more source

Pulmonary Deposition of Radionucleotide-Labeled Palivizumab: Proof-of-Concept Study

Frontiers in Pharmacology, 2020
ObjectiveCurrent prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV ...
Anushi E. Rajapaksa, Anushi E. Rajapaksa, Anushi E. Rajapaksa, Lien Anh Ha Do, Lien Anh Ha Do, Darren Suryawijaya Ong, Darren Suryawijaya Ong, Magdy Sourial, Duncan Veysey, Richard Beare, Richard Beare, William Hughes, William Yang, Robert J. Bischof, Robert J. Bischof, Amarin McDonnell, Peter Eu, Leslie Y. Yeo, Paul V. Licciardi, Paul V. Licciardi, Edward K. Mulholland, Edward K. Mulholland, Edward K. Mulholland   +22 more
doaj   +1 more source

Lentiviral and AAV-mediated expression of palivizumab offer protection against Respiratory Syncytial Virus infection

Scientific Reports, 2021
Respiratory syncytial virus (RSV) infection is a common cause of hospitalisation in infants and the elderly. Palivizumab prophylaxis is the only approved treatment modality but is costly and only offered to select vulnerable populations.
Agata Antepowicz, Omar Habib, Freja Kirsebom, Cecilia Johansson, Deborah R. Gill, Stephen C. Hyde   +5 more
doaj   +1 more source

The Use of Aerosolized Ribavirin in Respiratory Syncytial Virus Lower Respiratory Tract Infections in Adult Immunocompromised Patients: A Systematic Review [PDF]

, 2019
Introduction: Respiratory syncytial virus (RSV)–associated lower respiratory tract infection (LRTI) is a concern in immunocompromised patients. Aerosolized ribavirin (RBV AER) is used for treatment of RSV LRTI; however, adverse events and rising drug ...
Avery, Lisa M., Hoffmann, Charles, Whalen, Karen M.   +2 more
core   +2 more sources

Subcutaneous palivizumab (Synagis®) administration in an infant with congenital type 2B von Willebrand disease

Journal of Pediatric and Neonatal Individualized Medicine, 2015
Intramuscular injections are contra-indicated in infants with either acquired or congenital bleeding disorders. In such patients, it is unlicensed practice to administer vaccines by subcutaneous route.
Karel Allegaert, Maissa Rayyan, Veerle Cossey, Chris Van Geet   +3 more
doaj   +1 more source

Effectiveness of palivizumab immunoprophylaxis in infants with respiratory syncytial virus disease in Colombia

Journal of Infection in Developing Countries, 2021
Introduction: Respiratory syncytial virus (RSV) is one of the most important childhood infections. Objective: To evaluate the effectiveness and safety of palivizumab immunoprophylaxis in preterm infants at a high risk of severe respiratory syncytial ...
Juan Gabriel Piñeros, Jose De la Hoz-Valle, Clara Galvis, Astrid Celis, Oscar Ovalle, Carmen Cecilia Sandoval, Jaime Orrego, Saby Vides, Iader Rojas, Hernando Bustamante, Carlos Gallón, Jaime Alberto Mesa   +11 more
doaj   +1 more source

Outcome of Respiratory Syncytial Virus Lower Respiratory Tract Disease in Hematopoietic Cell Transplant Recipients Receiving Aerosolized Ribavirin: Significance of Stem Cell Source and Oxygen Requirement [PDF]

, 2013
Respiratory syncytial virus (RSV) infection is an important complication after hematopoietic cell transplantation (HCT), and RSV lower respiratory tract disease (LRD) results in substantial early mortality and late airflow obstruction among survivors ...
Boeckh, Michael, Campbell, Angela P., Chien, Jason W., Englund, Janet A., Leisenring, Wendy M., Seo, Sachiko, Xie, Hu   +6 more
core   +1 more source

Universal palivizumab prophylaxis for children with Down syndrome in Japan: analysis with interrupted time-series

Human Vaccines & Immunotherapeutics, 2021
Down syndrome (DS) is an independent risk factor for severe respiratory syncytial virus (RSV) infection. Palivizumab – passive immunization for RSV – is the only pharmacological measure for preventing severe disease.
Masato Takeuchi, Koji Kawakami
doaj   +1 more source

Guideline for the diagnosis, treatment, and prevention of respiratory syncytial virus infection in children in China

Pediatric Investigation, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is one of the most common respiratory pathogens in children under 5 years of age worldwide and it seriously threatens children's health. In recent years, great progress has been made in the field of RSV‐related diseases.
Committee of Pediatrics, China Medical Education Association, Subspecialty Group of Respiratory Diseases, Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of China Non‐public Medical Institution Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China Medical News and Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, Global Pediatric Respiratory Alliance, Beijing Hairun Charity Foundation   +16 more
wiley   +1 more source

Removal of the N-glycosylation sequon at position N116 located in p27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization [PDF]

, 2018
Prevention of severe lower respiratory tract infections in infants caused by the human respiratory syncytial virus (hRSV) remains a major public health priority. Currently, the major focus of vaccine development relies on the RSV fusion (F) protein since
Bailey, Dalan, Boeren, Marlies, Caljon, Guy, Cos, Paul, Delputte, Peter, Leemans, Annelies, Maes, Louis, Martinet, Wim, Pintelon, Isabel, Roose, Kenny, Saelens, Xavier, Schepens, Bert, Van der Gucht, Winke   +12 more
core   +1 more source