Results 71 to 80 of about 294,621 (346)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Recent advances in Palladium(II)-catalyzed activation of aromatic ring C–H bonds

Journal of Saudi Chemical Society, 2020
Palladium is a precious metal, which has been widely used for various organic transformations in the past decades. Currently, the palladium-catalyzed direct activation of the aromatic ring C–H bonds is one of the frontier areas in organic chemistry, and ...
Yin-ling Yun, Jie Yang, Yu-hang Miao, Jie Sun, Xiao-jing Wang   +4 more
doaj   +1 more source

Study on the thermodynamics and kinetics of the stripping of palladium from a typical palladium organic

, 2005
Includes bibliographical references.The aim of this thesis was to investigate the thermodynamics and the kinetics of the stripping of palladium from a typical palladium organic.
Brits, Johannes Hendrik Wilhelmus Machiel
core  

Palladium Thiolate Bonding of Carbon Nanotube Thermal Interfaces

, 2011
Carbon nanotube (CNT) arrays can be effective thermal interface materials with high compliance and conductance over a wide temperature range. Here, we study CNT interface structures in which free CNT ends are bonded using Pd hexadecanethiolate, Pd(SC(16 ...
G. U. Kulkarni, Bhuvana, Thiruvelu, Fisher, Timothy S., Xu, Xianfan, Stephen L. Hodson, Hodson, Stephen L., Baratunde A. Cola, Cola, Baratunde A., Thiruvelu Bhuvana, Timothy S. Fisher, Kulkarni, G. U., Xianfan Xu   +11 more
core   +1 more source

Stable complete methane oxidation over palladium based zeolite catalysts

Nature Communications, 2018
Increasing the use of natural gas engines is an important step to reduce the carbon footprint of mobility and power generation sectors. To avoid emissions of unburnt methane and the associated severe greenhouse effect of lean-burn engines, the stability ...
A. Petrov, D. Ferri, F. Krumeich, M. Nachtegaal, J. V. van Bokhoven, O. Kröcher   +5 more
semanticscholar   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Palladium-Catalyzed Asymmetric Alkylation of Ketone Enolates

, 2016
Palladium-Catalyzed Asymmetric Alkylation of Ketone ...
Barry M. Trost (1309395), Gretchen M. Schroeder (1551364)   +1 more
core   +1 more source

Oxidative Addition to Palladium(0) Made Easy through Photoexcited-State Metal Catalysis: Experiment and Computation.

Angewandte Chemie, 2019
Visible-light induced, palladium catalyzed alkylations of α,β-unsaturated acids with unactivated alkyl bromides are described. A variety of primary, secondary, and tertiary alkyl bromides are activated by the photoexcited palladium metal catalyst to ...
Rajesh Kancherla, K. Muralirajan, Bholanath Maity, Chenghao Zhu, Patricia E. Krach, L. Cavallo, M. Rueping   +6 more
semanticscholar   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Should nature restoration projects be able to stack multiple revenue streams from ecosystem services? Full impact accounting as a clear way forward

Nature-Based Solutions
“Private Finance” is increasingly positioned as being a solution to problems around nature degradation and combating climate change in the United Kingdom (UK). Payments for ecosystem services, when made by the private sector, are seen as an integral part
Phoebe Dunklin, Jacob Parry, Tom Gegg
doaj   +1 more source