Results 61 to 70 of about 297,364 (293)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Interaction of fcc-Palladium nano-crystals with Hydrogen during PECVD growth of Carbon nanotubes

, 2003
Using plasma-enhanced chemical vapor deposition (PECVD) with Acetylene and Ammoniac on Pd-specimens Carbon nanotubes (CNT) could be produced successfully. Two different devices are compared and the conditions for best growth conditions are explained. The
Tanemura, Masaki, Wunderlich, Wilfried
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Hacia una gestión efectiva de futuras pandemias en México

Salud Pública de México
No ...
Eduardo González Pier, Juan Rivera Dommarco   +1 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Machine learning to improve HIV screening using routine data in Kenya

Journal of the International AIDS Society
Introduction Optimal use of HIV testing resources accelerates progress towards ending HIV as a global threat. In Kenya, current testing practices yield a 2.8% positivity rate for new diagnoses reported through the national HIV electronic medical record ...
Jonathan D. Friedman, Jonathan M. Mwangi, Kennedy J. Muthoka, Benedette A. Otieno, Jacob O. Odhiambo, Frederick O. Miruka, Lilly M. Nyagah, Pascal M. Mwele, Edmon O. Obat, Gonza O. Omoro, Margaret M. Ndisha, Davies O. Kimanga   +11 more
doaj   +1 more source

Cardiotoxicity of palladium compounds [PDF]

Journal of Medical Biochemistry, 2013
Previous studies have shown that palladium has toxic effects on the kidney and liver, leads to deterioration of the general condition of animals, and could cause allergy in animals and humans. Considering the limited data about the influence of palladium
Perić Tanja S., Janković Slobodan M.
doaj  

Analyzing Platinum and Palladium Consumption and Demand Forecast in Japan

Resources, 2017
Platinum and palladium are used in small but essential quantities in a variety of advanced industrial sectors. Platinum and palladium are used as catalysts in various industrial sectors, especially in the car industry.
Yuna Seo, Shinichirou Morimoto
doaj   +1 more source

Electrochemical determination of hydrogen peroxide at glassy carbon electrode modified with palladium nanoparticles [PDF]

Journal of the Serbian Chemical Society, 2013
We report here the modification of glassy carbon electrode (GCE) with palladium nanoparticles and palladium film. The response to hydrogen peroxide on the modified electrode was examined using cyclic voltammetry and amperometry (at -0.2 V vs Ag/AgCl ...
Kitte Addisu Shimeles, Assresahegn Desalegn Birhanu, Soreta Refera Tesfaye   +2 more
doaj   +1 more source