Results 71 to 80 of about 426,395 (339)

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Perspectives of telemedicine-based services among family caregivers of patients with end-of-life cancer: a qualitative study in mainland China

BMC Palliative Care
Background Despite being driven by a strong sense of duty and familial obligation, providing care for patients nearing the end of life poses challenges for family caregivers.
Junchen Guo, Xianghua Xu, Chaoyi Liu, Ying Wang, Yongyi Chen   +4 more
doaj   +1 more source

Experiences of a Novel Integrated Service for Older Adults at Risk of Frailty: A Qualitative Study

Journal of Patient Experience, 2023
The UK has a significant and growing population of older adults with frailty and complex healthcare needs, necessitating innovative care solutions. This study aimed to explore patients’ and carers’ experiences of a novel integrated service that was set ...
Imogen Wilson MSc, Blessing O Ukoha-kalu PhD, Mabel Okoeki PhD, Joseph Clark PhD, Jason W Boland PhD, Sophie Pask MSc, Ugochinyere Nwulu MSc, Helene Elliott-Button PhD, Anna Folwell MBChB, Miriam J Johnson MD, Daniel Harman MBChB, Fliss EM Murtagh PhD   +11 more
doaj   +1 more source

Medical students writing on death, dying and palliative care : a qualitative analysis of reflective essays [PDF]

, 2016
Background: Medical students and doctors are becoming better prepared to care for patients with palliative care needs and support patients at the end of life. This preparation needs to start at medical school.
Boland, Jason W, Boland, Jason W., Dikomitis, Lisa, Gadoud, Amy   +3 more
core   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

A National Quality Initiative to Improve Palliative Care Outcomes: Identifying Enabling Factors that Drive Quality Improvement

Palliative Medicine Reports
Background: The Palliative Care Outcomes Collaboration (PCOC), established in 2005 and funded by the Australian Government, is a national quality improvement initiative that integrates patient outcome measures into routine clinical practice.
Sabina Clapham, Katherine Clark, Kylie Draper, Fiorina Mastroianni, Jesse Rand, Lisa Redwood, David Currow   +6 more
doaj   +1 more source

Translation and cultural adaptation of the Integrated Palliative care Outcome Scale including cognitive interviewing with patients and staff

BMC Palliative Care, 2017
Background To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures.
Ingela Beck, Ulrika Olsson Möller, Marlene Malmström, Anna Klarare, Henrik Samuelsson, Carina Lundh Hagelin, Birgit Rasmussen, Carl Johan Fürst   +7 more
doaj   +1 more source

Response to “The opinion of French pulmonologists and palliative care physicians on non-invasive ventilation during palliative sedation at end of life: a nationwide survey’’

BMC Palliative Care, 2023
We have several major concerns about this article [Guastella et al 2021]. Although it states that it is about palliative sedation, it is not. Rather, it is about the French Claeys Leonetti Law about Continuous Deep Sedation (CDS) at the end of life [Loi ...
Robert Twycross, Christina Faull, David Wenzel, David Oliver   +3 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Multicomponent Interventions for Adults With Cancer Cachexia: A Systematic Review

Journal of Cachexia, Sarcopenia and Muscle
Background Cancer cachexia has substantial impacts on people's quality of life. There is no current gold standard treatment, but the complex pathophysiology of cachexia suggests that a multitargeted and individualised treatment approach is needed.
Megan Bowers, Carmine Petrasso, Amy McLuskie, Joanne Bayly, Barry J. A. Laird, Irene J. Higginson, Matthew Maddocks   +6 more
doaj   +1 more source