Results 1 to 10 of about 62,902 (314)

Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid [PDF]

open access: yesCurrent Research in Toxicology
Aims: Cytochrome P450 2E1 (CYP2E1) is a mammalian monooxygenase expressed at high levels in the liver that metabolizes low molecular weight pollutants and drugs, as well as endogenous fatty acids and ketones.
Zaria K. Killingsworth   +6 more
doaj   +2 more sources

Molecular dynamics simulation of the interaction between palmitic acid and high pressure CO2

open access: yesRoyal Society Open Science, 2023
In this study, molecular dynamics simulation was used to explore the interaction characteristics of palmitic acid and CO2, and the effects of temperature and pressure on the solubility of palmitic acid in CO2 were investigated.
Fei Li   +4 more
doaj   +1 more source

Palmitic Acid Promotes Lung Metastasis of Melanomas via the TLR4/TRIF-Peli1-pNF-κB Pathway

open access: yesMetabolites, 2022
A high-fat diet plays an important role in aggravating cancers. Palmitic acid (PA) is one of the components of saturated fatty acids; it has been reported to promote tumor proliferation in melanomas, but the signal transduction pathway mediated by ...
Xuedan Zhang   +13 more
doaj   +1 more source

Palmitic acid: Enabling the tumor’s nerves

open access: yesCell Metabolism, 2022
Diet can influence tumor aggressiveness. Recently in Nature, a study by Pascual et al. provided evidence that dietary palmitic acid induces an epigenetic memory by modulating particular histone methylation marks in cancer cells. This allows cancer cells to activate extracellular matrix secretion from Schwann cells of the tumor microenvironment, which ...
Alkan, H. Furkan   +2 more
openaire   +3 more sources

Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma

open access: yesScientific Reports, 2021
Saturated fatty acids such as palmitic acid promote inflammation and insulin resistance in peripheral tissues, contrasting with the protective action of polyunsaturated fatty acids such docosahexaenoic acid.
Hamza Amine   +2 more
doaj   +1 more source

Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway

open access: yesFrontiers in Immunology, 2020
Palmitic acid is the most common saturated fatty acid in animals, plants, and microorganisms. Studies highlighted that palmitic acid plays a significant role in diverse cellular processes and viral infections.
Yepin Yu   +16 more
doaj   +1 more source

Protection of palmitic acid-mediated lipotoxicity by arachidonic acid via channeling of palmitic acid into triglycerides in C2C12 [PDF]

open access: yesJournal of Biomedical Science, 2014
Excessive saturated fatty acids have been considered to be one of major contributing factors for the dysfunction of skeletal muscle cells as well as pancreatic beta cells, leading to the pathogenesis of type 2 diabetes.PA induced cell death in a dose dependent manner up to 1.5 mM, but AA protected substantially lipotoxicity caused by PA at even low ...
Hyae Gyeong Cheon, Young Sik Cho
openaire   +4 more sources

Activation of Palmitic Acid by Human Spermatozoa [PDF]

open access: yesJournal of Andrology, 1985
Human spermatozoa were studied to determine if a long chain fatty acid, CoASH ligase (AMP) (E.C. 6.2.1.3), was present. Ligase activity was measured with a radioligand millipore filter technique and was readily detectable in spermatozoa or in the protein fraction extracted with Triton X‐100, but was not present in seminal plasma.
Robert E. Jones   +2 more
openaire   +3 more sources

Effect of docosahexaenoic acid plus insulin on atherosclerotic human endothelial cells

open access: yesJournal of Inflammation, 2021
Background Atherosclerosis is touted as one of the most critical consequences of diabetes mellitus indicated by local inflammation of endothelial cells. The Effect of Omega 3 fatty acids, mainly docosahexaenoic acid (DHA), has been investigated in cells ...
Aysan Eslami Abriz   +7 more
doaj   +1 more source

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