Results 271 to 280 of about 5,096,341 (376)

Unveiling the Mechanism of Action of Palmitic Acid, a Human Topoisomerase 1B Inhibitor from the Antarctic Sponge <i>Artemisina plumosa</i>. [PDF]

Int J Mol Sci
Ottaviani A, Pietrafesa D, Soren BC, Dasari JB, Olsen SSH, Messina B, Demofonti F, Chicarella G, Agama K, Pommier Y, Morozzo Della Rocca B, Iacovelli F, Romeo A, Falconi M, Baker BJ, Fiorani P.   +15 more
europepmc   +1 more source

Adipocyte exosome miR‐4472 inhibits glucose uptake in skeletal muscle through downregulation of MEF2D

Journal of Diabetes Investigation, EarlyView.
Adipocyte exosome miR‐4472 inhibits glucose uptake in skeletal muscle through downregulating the expression of MEF2D/GLUT4. ABSTRACT Aims/introduction Previous studies have found that miR‐4472 is overexpressed in the serum of individuals with obesity and type 2 diabetes mellitus (T2DM), which may participate in the process of obesity‐induced T2DM ...
Chaoyue Sun, Xin Wen, Xiaolong Chu, Fangyuan Yuan, Yao Chen, Chaoling Peng, Meiyu Qian, Jin Mei, Juan Wang, Yidan Jiang, Shibo Xu, Cuizhe Wang, Wei Li, Jun Zhang   +13 more
wiley   +1 more source

Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice. [PDF]

Nat Commun
Yin W, Xu H, Bai Z, Wu Y, Zhang Y, Liu R, Wang Z, Zhang B, Shen J, Zhang H, Chen X, Ma D, Shi X, Yan L, Zhang C, Jiang H, Chen K, Guo D, Niu W, Yin H, Zhang WJ, Luo C, Xie X.   +22 more
europepmc   +1 more source

Uhrf1 downregulation promotes β‐cell dedifferentiation by decreasing Foxo1 expression in type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This finding reveals the important role of Uhrf1 in the β‐cell dedifferentiation of T2D, providing a potential target for its treatment. ABSTRACT Background Islet β‐cell dedifferentiation is a major pathological mechanism of type 2 diabetes (T2D). Forkhead box o1 (Foxo1) is a master regulator of β‐cell dedifferentiation.
Lanfang Fu, Juyun Zhang, Zhu Lin, Xubiao Meng   +3 more
wiley   +1 more source

Research of the Measurement on Palmitic Acid in Edible Oils by Near-Infrared Spectroscopy [PDF]

, 2011
Hui Li, Jingzhu Wu, Cuiling Liu
openalex   +1 more source

Lipotoxicity of palmitic acid is associated with DGAT1 downregulation and abolished by PPARα activation in liver cells. [PDF]

J Lipid Res
Moliterni C, Vari F, Schifano E, Tacconi S, Stanca E, Friuli M, Longo S, Conte M, Salvioli S, Gnocchi D, Mazzocca A, Uccelletti D, Vergara D, Dini L, Giudetti AM.   +14 more
europepmc   +1 more source

Role of epicardial adipose tissue in heart failure with preserved ejection fraction: An emerging molecular mechanism and therapeutic potential

Obesity Reviews, EarlyView.
Summary With the evolving landscape of diseases, heart failure with preserved ejection fraction (HFpEF) now encompasses more than half of all heart failure patients. This condition is clinically diverse, involving multiple organ systems and often occurring alongside the aging process.
Zhongwen Qi, Dan Wu, Zhipeng Yan, Qing Wang, Yiming Li, Junnan Zhao, Fengqin Xu   +6 more
wiley   +1 more source

Subcellular expression of CYP2E1 in HepG2 cells impacts response to free oleic and palmitic acid. [PDF]

Curr Res Toxicol
Killingsworth ZK, Misare KR, Ryan AS, Ampolini EA, Mendenhall TT, Engevik MA, Hartman JH.   +6 more
europepmc   +1 more source

Defective lymphatic vasculature in obesity

Obesity Reviews, EarlyView.
Summary Lymphedema is an important, and often underdiagnosed complication of obesity and is likely due to acquired defects in the lymphatic vasculature. Study of diet‐induced obesity animal models have indicated defective lymphatic vasculatures might extend to other anatomical sites, especially visceral depots.
Jingjing Zhu, John P. H. Wilding, Ji Hu
wiley   +1 more source