Results 101 to 110 of about 32,016,499 (171)

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons-8

, 2011
Copyright information:Taken from "Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons"http://www.biomedcentral.com/1471-2121/8/22BMC Cell Biology 2007;8():22-22.Published online
Carina von Schantz (45483), Anu Jalanko (45488), Outi Kopra (7927), Tarja Salonen (71261), Jani Saarela (50412), Matti Jauhiainen (71262), Annina Lyly (71260), Aija Kyttälä (71263)   +7 more
core   +1 more source

Investigations into β-ketoacyl-ACP Synthase III and enoyl-ACP reductase of plant fatty acid synthase [PDF]

, 1999
An antisense transgenic approach was taken in order to assess the importance of P-ketoacyl-ACP- Synthase III (KAS III) in regulation and initiation of de novo fatty acid synthesis in planta.
Clarke, Hayley Diana
core  

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Yinuo Wang, Kai Yao, Ling Wang, Jiancheng Huang, Yongfang Xiao, Hongyao Chen, Bo Liu, Cliff Y. Yang, Jijun Zhao   +9 more
doaj   +1 more source

Akap5 links synaptic dysfunction to neuroinflammatory signaling in a mouse model of infantile neuronal ceroid lipofuscinosis

Frontiers in Synaptic Neuroscience
Palmitoylation and depalmitoylation represent dichotomic processes by which a labile posttranslational lipid modification regulates protein trafficking and degradation.
Kevin P. Koster, Zach Fyke, Thu T. A. Nguyen, Amanda Niqula, Lorena Y. Noriega-González, Kevin M. Woolfrey, Mark L. Dell’Acqua, Stephanie M. Cologna, Akira Yoshii, Akira Yoshii, Akira Yoshii   +10 more
doaj   +1 more source

Oil trait and multi-omic analyses reveal the regulatory network of triacylglycerol and fatty acid accumulation in hexaploid Camellia oleifera across different harvesting stages

BMC Plant Biology
Background The regulatory network governing triacylglycerol (TAG) and fatty acid (FA) accumulation in hexaploid Camellia oleifera kernels remains unclear due to the lack of an appropriate reference genome.
Jugang Wang, Jian Song, Xiaomin Gao, Jiali Wang, Tianyu Huang, Manmei Zeng, Zhoujun Zhu, Min Liu, Zuhua Wang   +8 more
doaj   +1 more source

pdf1 , a Palmitoyl Protein Thioesterase 1 Ortholog in Schizosaccharomyces pombe : a Yeast Model of Infantile Batten Disease

Eukaryotic Cell, 2004
ABSTRACT Infantile Batten disease is a severe neurodegenerative storage disorder caused by mutations in the human PPT1 (palmitoyl protein thioesterase 1) gene, which encodes a lysosomal hydrolase that removes fatty acids from lipid-modified proteins.
Steve K, Cho, Sandra L, Hofmann
openaire   +2 more sources

Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice

Neurobiology of Disease, 2005
The neuronal ceroid lipofuscinoses are a newly-recognized group of lysosomal storage disorders in which neurodegeneration predominates. The pathophysiological basis for this is unknown.
Tuhin Virmani, Praveena Gupta, Xinran Liu, Ege T. Kavalali, Sandra L. Hofmann   +4 more
doaj   +1 more source

Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease

Biology Open, 2014
Wolfram syndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH iron ...
Melanie A. Jones, Sami Amr, Aerial Ferebee, Phung Huynh, Jill A. Rosenfeld, Michael F. Miles, Andrew G. Davies, Christopher A. Korey, John M. Warrick, Rita Shiang, Sarah H. Elsea, Santhosh Girirajan, Mike Grotewiel   +12 more
doaj   +1 more source

Palmitoyl-acyl Carrier Protein Thioesterase in Cotton (Gossypium hirsutum L.): Biochemical and Molecular Characterization of a Major Mechanism for the Regulation of Palmitic Acid Content [PDF]

, 2001
The relatively high level of palmitic acid (22 mol%) in cottonseeds may be due in part to the activity of a palmitoyl-acyl carrier protein (ACP) thioesterase (PATE).
Huynh, Tu T
core  

An over-expression system for characterizing Ppt1 function in Drosophila

BMC Neuroscience, 2003
Background The infantile onset form of Neuronal Ceroid Lipofuscinoses (INCL) is the earliest and most severe form of NCL, with neurological symptoms that reflect massive neurodegeneration in the CNS and retina.
Korey Christopher A, MacDonald Marcy E
doaj   +1 more source