Results 91 to 100 of about 32,016,499 (171)

Identification of palmitoyl protein thioesterase 1 substrates defines roles for synaptic depalmitoylation

, 2020
SUMMARY We report here the identification of substrates of the depalmitoylating enzyme PPT1 by quantitative mass spectrometry. We first used a stringent Acyl Resin-Assisted Capture (Acyl RAC) screen in which PPT1 knockout (KO) mouse brain proteins showing increased in vivo palmitoylation are identified as putative PPT1 substrates.
Gorenberg, Erica L., Zhao, Helen R., Bishai, Jason, Chou, Vicky, Wirak, Gregory S., Lam, TuKiet T., Chandra, Sreeganga S.   +6 more
openaire   +1 more source

The activity of palmitoyl-protein thioesterase 1 in leukocyte homogenate measured by fluorimetric method

, 2020
Neuronalne ceroidne lipofuscinoze su skupina genetski nasljednih lizosomskih neurodegenerativnih bolesti karakteriziranih unutarstaničnim nakupljanjem skladišnog materijala autofluorescentnog lipopigmenta koji uzrokuje progresivnu neurološku degeneraciju
Hulita, Andrea
core   +1 more source

Palmitoylation by ZDHHC4 inhibits TRPV1-mediated nociception

EMBO Reports
Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin-sensitive ion channel implicated in pain sensation. While TRPV1 potentiation in hyperalgesia development has been extensively investigated, its functional decline during pain relief remains ...
Youjing Zhang, Mengyu Zhang, Cheng Tang, Junyan Hu, Xufeng Cheng, Yang Li, Zefeng Chen, Yuan Yin, Chang Xie, Dongdong Li, Jing Yao   +10 more
doaj   +1 more source

The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB‐85387 Is Associated With Weight Loss in Mice With Obesity

Obesity Science &Practice, Volume 12, Issue 2, April 2026.
ABSTRACT Background GLP‐1 therapies for obesity are limited by side effects and weight regain is common after treatment ends. Therefore, alternative treatments with new mechanisms are needed for sustained weight loss. Human MOGAT2 regulates triglyceride metabolism and its inhibition reduces weight in people with obesity, making MOGAT2 a promising ...
J. Jose Corbalan, Pranavi Jagadeesan, Chia‐Yu Huang, James R. Beasley, Joseph T. Nickels Jr.   +4 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, Volume 40, Issue 4, Page 1642-1660, April 2026.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Translational Psychiatry
The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1).
Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge   +18 more
doaj   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

Mouse Palmitoyl Protein Thioesterase: Gene Structure and Expression of cDNA

, 1998
Palmitoyl protein thioesterase (PPT) is the defective enzyme in infantile neuronal ceroid lipofuscinosis (INCL), which is a recessively inherited, progressive neurodegenerative disorder. We present here the cloning, chromosomal mapping, genomic structure,
Tarja Salonen, Anu Jalanko, Nina Horelli-Kuitunen, Elina Hellsten, Leena Peltonen   +4 more
core   +1 more source

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

The Journal of Clinical Investigation, 2022
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl ...
Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper   +29 more
doaj   +1 more source

Proteomic Profiling of Alveolar Macrophages Identifies Loss of Lysosomal Content as an Indicator of Nanofiber‐Induced Frustrated Phagocytosis

Small, Volume 22, Issue 11, 20 February 2026.
This proteomic study examines how nanofibers affect lung macrophages by analyzing protein changes following exposure to various fibrous materials. Nanofibers triggered the release of inflammatory enzymes, and importantly, lysosomal content release was identified as an early event associated with frustrated phagocytosis. Seventeen sensitive and relevant
Tobias Stobernack, Antje Vennemann, Carla Ribalta, Julia Schendel, Oliver Gräb, Rico Ledwith, Mario Pink, Andrea Haase, Martin Wiemann, Verónica I. Dumit   +9 more
wiley   +1 more source