Results 71 to 80 of about 32,016,499 (171)

Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis

Neurobiology of Disease, 2007
Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1−/−) and the ...
Catherine Kielar, Lucy Maddox, Ellen Bible, Charlie C. Pontikis, Shannon L. Macauley, Megan A. Griffey, Michael Wong, Mark S. Sands, Jonathan D. Cooper   +8 more
doaj   +1 more source

Characterization of heterogeneous metabolism in hepatocellular carcinoma identifies new therapeutic target and treatment strategy

Frontiers in Immunology, 2023
BackgroundMetabolic reprogramming is a well-known hallmark of cancer. Systematical identification of clinically relevant metabolic subtypes of Hepatocellular carcinoma (HCC) is critical to understand tumor heterogeneity and develop efficient treatment ...
Jiabin Yang, Jiabin Yang, Liangtang Zeng, Liangtang Zeng, Ruiwan Chen, Shangyou Zheng, Yu Zhou, Rufu Chen, Rufu Chen   +8 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Defective anterograde protein-trafficking contributes to endoplasmic reticulum-stress in a CLN1 disease model

Neurobiology of Disease
Lysosomal storage disorders (LSDs) represent 70 inherited metabolic diseases, in most of which neurodegeneration is a devastating manifestation. The CLN1 disease is a fatal neurodegenerative LSD, caused by inactivating mutations in the CLN1 gene encoding
Nisha Plavelil, Abhilash P. Appu, K.C. Gopal, Avisek Mondal, Neil Perkins, Anil B. Mukherjee   +5 more
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science
Cardiac fibrosis, a key pathological feature of cardiac remodeling, is a major contributor to mortality in older patients with heart failure. The underlying mechanisms are complex, involving alterations in intercellular communication and chronic ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
doaj   +1 more source

Long‐term stability of RNAi‐mediated gene silencing in high‐oleic soybean lines

Crop Science, Volume 66, Issue 4, July/August 2026.
Abstract In Brazil, renewable biofuel is mainly produced from soybean [Glycine max (L.) Merr.] oil. Typically, soybean‐derived oil contains approximately 25% of the monounsaturated oleic acid, 13% of the saturated fatty acid palmitic, and 55% of the polyunsaturated fatty acid (PUFA) linoleic acid.
Jéssica Carrijo, Júlio Carlyle Macedo Rodrigues, Kenny Bonfim, Elínea de Oliveira Freitas, Renan Miguel dos Anjos, Nicolau Brito da Cunha, Elibio Leopoldo Rech, Giovanni Rodrigues Vianna   +7 more
wiley   +1 more source

Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer

Pharmaceutics
Gene therapy approaches may target skeletal muscle due to its high protein-expressing nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric fields (PEFs) can be termed electroporation or electrotransfer.
Amanda Sales Conniff, Julie Singh, Richard Heller, Loree C. Heller   +3 more
doaj   +1 more source

Adeno-associated virus 2-mediated gene therapy decreases autofluorescent storage material and increases brain mass in a murine model of infantile neuronal ceroid lipofuscinosis

Neurobiology of Disease, 2004
Infantile neuronal ceroid lipofuscinosis (INCL) is the earliest onset form of a class of inherited neurodegenerative disease called Batten disease.
Megan Griffey, Ellen Bible, Carole Vogler, Beth Levy, Praveena Gupta, Jonathan Cooper, Mark S Sands   +6 more
doaj   +1 more source

Understanding of Molecular Mechanisms and Breeding Strategies for Enhancing Oleic Acid Biosynthesis in Oil Crops

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Oleic acid (C18:1), a monounsaturated fatty acid, is a key determinant of nutritional value and oxidative stability of vegetable oils. Increasing its concentration has therefore become a central objective in oilseed crop improvement. This review summarizes current knowledge on the molecular mechanisms and breeding strategies underlying oleic ...
Muhammad Jawad Umer, Yuanxiao Zhu, Qing Lu, Hao Liu, Shaoxiong Li, Haifen Li, Runfeng Wang, Qianxia Yu, Yanbin Hong, Xuanqiang Liang, Lu Huang, Shengchun Zhang, Xiaoping Chen   +12 more
wiley   +1 more source