Results 61 to 70 of about 32,016,499 (171)
, 2011 Copyright information:Taken from "Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons"http://www.biomedcentral.com/1471-2121/8/22BMC Cell Biology 2007;8():22-22.Published online
Carina von Schantz (45483) +7 more
core +1 more source
Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis
Cell Proliferation, EarlyView.Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang +12 more
wiley +1 more source
Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase [PDF]
, 2006 The mammalian long-chain acyl-CoA thioesterase, the enzyme that catalyses the hydrolysis of acyl-CoAs to free fatty acids, contains two fused 4HBT (4-hydroxybenzoyl-CoA thioesterase) motifs.
Martin, J. L. +9 more
core +1 more source
Identification of three novel mutations of the palmitoyl-protein thioesterase-1 (PPT1) gene in children with neuronal ceroid-lipofuscinosis [PDF]
Human Mutation, 2000 Eight unrelated children with progressive neurological deterioration and granular osmiophilic deposits (GROD) due to an underlying palmitoyl-protein thioesterase deficiency were analyzed for mutations in the PPT1 gene. Three novel mutations (G118D, Q291X and F84del) were identified.
S, Waliany +4 more
openaire +2 more sources
An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model
EMBO Molecular Medicine, 2023 Hematopoietic stem and progenitor cells (HSPCs) can establish a long‐lasting microglia‐like progeny in the central nervous system of properly myeloablated hosts. We exploited this approach to treat the severe CLN1 neurodegenerative disorder, which is the
Marco Peviani +11 more
doaj +1 more source
The FEBS Journal, EarlyView.The microbial degradation of synthetic polyesters such as polyethylene terephthalate (PET) is mediated by diverse α/β‐hydrolases, many of which remain poorly characterized. In this study, we investigated the α/β‐hydrolase SM0281 from Sinorhizobium meliloti and found that it exhibits robust carboxylesterase and polyesterase activities toward PET, PCL ...
Sofia Lemak +7 more
wiley +1 more source
Biomolecules, 2022 Drug combination and drug repurposing are two strategies that allow to find novel oncological therapies, in a faster and more economical process. In our previous studies, we developed a novel model of drug combination using antineoplastic and different ...
Diana Duarte +3 more
doaj +1 more source
New Phytologist, Volume 251, Issue 4, Page 2152-2167, August 2026.Three genotypes – a heat‐resistant maize (Zea mays), a heat‐susceptible maize, and a sorghum (Sorghum bicolor) variety – were grown to the V4 stage in growth chambers under optimal conditions or subjected to heat stress. Plants were grown in soil containing a complex microbial community, or in the same soil with a depleted microbiome.
Nate Korth +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 42, 28 July 2026.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
wiley +1 more source
, 2011 Copyright information:Taken from "Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons"http://www.biomedcentral.com/1471-2121/8/22BMC Cell Biology 2007;8():22-22.Published online
Carina von Schantz (45483) +7 more
core +1 more source