Results 261 to 270 of about 39,498 (303)

Palmitoylation of Tubulin

Biochemical and Biophysical Research Communications, 1997
Tubulin is a very water soluble protein, yet a significant portion is firmly associated with cell membranes. Because recent work has shown that palmitoylation is a dynamic process that can alter the targeting of proteins to membranes, we tested whether or not tubulin could be palmitoylated to account for its membrane location.
A M, Zambito, J, Wolff
openaire   +2 more sources

Palmitoylation and palmitoyl-transferases in Plasmodium parasites

Biochemical Society Transactions, 2015
Protein post-translational modifications (PTM) are commonly used to regulate biological processes. Protein S-acylation is an enzymatically regulated reversible modification that has been shown to modulate protein localization, activity and membrane binding.
Nicola, Hodson, Brandon, Invergo, Julian C, Rayner, Jyoti S, Choudhary   +3 more
openaire   +2 more sources

STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice

Science Signaling, 2023
Constitutive activation of the transcription factor STAT3 (signal transducer and activator of transcription 3) contributes to the malignancy of many cancers such as hepatocellular carcinoma (HCC) and is associated with poor prognosis.
Yi Jiang, Yuejie Xu, Chengliang Zhu, Guifang Xu, Lei Xu, Zijian Rao, Lixing Zhou, Ping Jiang, Sara Malik, Jing-Yuan Fang, Hening Lin, Mingming Zhang   +11 more
semanticscholar   +1 more source

High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT

Gut
Objective Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain a mystery.
Lang Bu, Zhengkun Zhang, Jianwen Chen, Yizeng Fan, Jinhe Guo, Yaqing Su, Huan Wang, Xiaomei Zhang, Xueji Wu, Qiwei Jiang, Bing Gao, Lei Wang, Kunpeng Hu, Xiang Zhang, Wei Xie, Wenyi Wei, Ming Kuang, Jianping Guo   +17 more
semanticscholar   +1 more source

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis

Science immunology
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD membrane translocation and pore formation are not fully understood.
A. Balasubramanian, A. Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Dang Fabin, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, H. Yu, Mei Chen, Steven Kolakowski, S. Trauger, M. R. Larsen, Wenyi Wei, Haoying Wu, Jonathan C. Kagan, Judy Lieberman, Hongbo R. Luo   +23 more
semanticscholar   +1 more source

Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetase 1

Antioxidants and Redox Signaling, 2022
Aims: Impaired fatty acid oxidation (FAO) in mitochondria of hepatocytes causes lipid accumulation and excessive production of reactive oxygen species (ROS) and oxidative damage, leading to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase
S. Zeng, Fan Wu, Mengyue Chen, Yun Li, Mengyue You, Y. Zhang, Ping Yang, Li Wei, X. Ruan, Lei Zhao, Yaxi Chen   +10 more
semanticscholar   +1 more source

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release

Proceedings of the National Academy of Sciences of the United States of America
Significance Pyroptosis is an inflammatory form of cell death that plays important roles in host defense and inflammatory disorders. Despite intensive studies, the molecular events underlying the gasdermin D (GSDMD)-mediated pyroptosis remain poorly ...
Zhonghua Liu, Sai Li, Chuanping Wang, Kaylynn J Vidmar, Syrena Bracey, Ling Li, Belinda Willard, Masaru Miyagi, Tong Lan, Bryan C. Dickinson, A. Osme, Theresa T. Pizarro, T. S. Xiao   +12 more
semanticscholar   +1 more source

ZDHHC20 mediated S-palmitoylation of fatty acid synthase (FASN) promotes hepatocarcinogenesis

Molecular Cancer
Protein palmitoylation is a reversible fatty acyl modification that undertakes important functions in multiple physiological processes. Dysregulated palmitoylations are frequently associated with the formation of cancer.
Yaqi Mo, Yamei Han, Yang Chen, Chunling Fu, Qing Li, Zhuang Liu, Mingming Xiao, Bo Xu   +7 more
semanticscholar   +1 more source

Assays of protein palmitoylation

Methods, 2006
Protein palmitoylation plays an important role in the structure and function of a wide array of proteins. Unlike other lipid modifications, protein palmitoylation is highly dynamic and cycles of palmitoylation and depalmitoylation can regulate protein function and localization.
Renaldo C, Drisdel, John K, Alexander, Ayaz, Sayeed, William N, Green   +3 more
openaire   +2 more sources

Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery.

ACS Chemical Biology
S-palmitoylation is a reversible and dynamic process that involves the addition of long-chain fatty acids to proteins. This protein modification regulates various aspects of protein function, including subcellular localization, stability, conformation ...
Shaojun Pei, Hai-long Piao
semanticscholar   +1 more source