Results 271 to 280 of about 39,498 (303)

Altered Protein Palmitoylation as Disease Mechanism in Neurodegenerative Disorders

Journal of Neuroscience
Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in regulating various aspects of neuronal function through altering protein membrane-targeting, stabilities, and protein–protein interaction profiles.
J. Włodarczyk, Raja Bhattacharyya, Kim Dore, Gary P H Ho, Dale D. O. Martin, Rebeca Mejías, Karin Hochrainer   +6 more
semanticscholar   +1 more source

Palmitoylation of serotonin receptors

Biochemical Society Transactions, 2013
The covalent attachment of palmitic acid to one or more cysteine residues (S-palmitoylation) is a widespread modification of signalling proteins. With the finding that palmitoylation is a dynamic process, it is now widely accepted that repeated cycles of palmitoylation/depalmitoylation could be involved in the regulation of multiple signalling ...
Nataliya, Gorinski, Evgeni, Ponimaskin
openaire   +2 more sources

Palmitoylation promotes pores

Science Signaling
Palmitoylation of intact or cleaved gasdermin D causes plasma membrane pore formation.
openaire   +2 more sources

Aberrant palmitoylation in Huntington disease

Biochemical Society Transactions, 2015
Huntington disease (HD) is an adult-onset neurodegenerative disease caused by a CAG expansion in the HTT gene. HD is characterized by striatal atrophy and is associated with motor, cognitive and psychiatric deficits. In the presence of the HD mutation, the interactions between huntingtin (HTT) and huntingtin interacting protein 14 (HIP14 or DHHC17) and
Shaun S, Sanders, Michael R, Hayden
openaire   +2 more sources

Palmitoylation and colitis

Science Signaling, 2020
Interrupting the palmitoylation-depalmitoylation cycle of the transcriptional regulator STAT3 relieves IBD symptoms in mice.
openaire   +1 more source

ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.

Molecules and Cells, 2023
Sihao Zheng, Xiangyong Que, Shuxian Wang, Qi Zhou, Xiaoke Xing, Liang Chen, C. Hou, Junfeng Ma, Ping An, Yihan Peng, Yi Yao, Qibin Song, Juanjuan Li, Pingfeng Zhang, Huadong Pei   +14 more
semanticscholar   +1 more source

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

Nature
Gang Du, L. Healy, Liron David, Caitlin Walker, T. El‐Baba, Corinne A. Lutomski, Byoungsook Goh, Bowen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, A. Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R. Luo, Jonathan C. Kagan, Sungwhan F. Oh, Carol V. Robinson, Judy Lieberman, Hao Wu   +22 more
semanticscholar   +1 more source

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

Nature Cancer
Liang Zhou, Guangyu Lian, Tao Zhou, Zhe Cai, Shuai Yang, Weining Li, Lilin Cheng, Ying Ye, Mingfeng He, Jianru Lu, Qifeng Deng, Bihui Huang, Xiaoqian Zhou, Desheng Lu, Feng Zhi, Jun Cui   +15 more
semanticscholar   +1 more source

A palmitoylation–depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis

Nature Cell Biology
Na Zhang, Jian Zhang, Yuanxin Yang, Hengyue Shan, Shouqiao Hou, Hongwen Fang, Min Ma, Zhongwen Chen, Li Tan, Daichao Xu   +9 more
semanticscholar   +1 more source

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

Nature Biomedical Engineering, 2019
Han Yao, Jiang Lan, Chushu Li, Hubing Shi, J. Brosseau, Huanbin Wang, Haojie Lu, Caiyun Fang, Yao Zhang, Lunxi Liang, Xiaolin Zhou, Chaojun Wang, Yu Xue, Yun Cui, Jie Xu   +14 more
semanticscholar   +1 more source