Results 21 to 30 of about 14,134 (231)

Janus kinase inhibitors in palmoplantar pustulosis: a mixed-methods feasibility (JAKPPPOT) trial protocol [PDF]

BMJ Open
Background Palmoplantar pustulosis (PPP) is a rare, debilitating inflammatory skin disease involving painful pustules on the palms and soles. Janus kinase (JAK) inhibitors target pathways relevant to PPP disease biology but also confer a risk of major ...
Weiyu Ye, Suzie Cro, James B Galloway, Sarah Chapman, C H Smith, Kingsley Powell, Jonathan Barker, Ann Naylor, Helen McAteer, John Gregory, David Gleeson, April Qin, Jade Pizzato, Manpreet K Sagoo, Lucy Moorhead, Andrew E Pink, Richard Woolf, Satveer K Mahil   +17 more
doaj   +2 more sources

Palmoplantar Pustulosis as an Immune-Mediated Inflammatory Disease with a Possible Relevance of Th17 Cell Plasticity: A Narrative Review. [PDF]

Dermatol Ther (Heidelb)
Palmoplantar pustulosis (PPP) is an immune-mediated inflammatory disease (IMID) of the skin that causes the formation of sterile pustules on the palms and soles.
Terui T, Murakami M, Okubo Y, Hayama K, Fujita H.   +4 more
europepmc   +2 more sources

Metabolic profiling of psoriasis vulgaris and palmoplantar pustulosis. [PDF]

Exp Dermatol
Psoriasis is a chronic inflammatory skin disorder with various subtypes, including psoriasis vulgaris (PV) and palmoplantar pustulosis (PPP). Metabolomics studies have provided insights into psoriasis pathogenesis.
Lee Y, Kim SR, Ban MS, Lee H, Cho JY, Jo SJ.   +5 more
europepmc   +2 more sources

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis [PDF]

medRxiv
Background: Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manifests with painful pustular eruptions on the palms and soles.

core   +7 more sources

Jumihaidokuto (Shi-Wei-Ba-Du-Tang), a Kampo Formula, Decreases the Disease Activity of Palmoplantar Pustulosis [PDF]

Dermatology Research and Practice, 2016
Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by sterile intraepidermal pustules associated with erythematous scaling on the palms and soles.
Megumi Mizawa, Teruhiko Makino, Chieko Inami, Tadamichi Shimizu   +3 more
doaj   +4 more sources

Biologics as a novel treatment option for palmoplantar pustulosis: a comprehensive review. [PDF]

Postepy Dermatol Alergol
Introduction Palmoplantar pustulosis (PPP) is a complex inflammatory skin disease. Currently, no standardized treatments exist, and traditional systemic therapies often display limited effectiveness and substantial adverse effects.
Leong HF, Wang WH, Peng F.
europepmc   +2 more sources

Treatment Patterns and Negative Health Outcomes in Palmoplantar Pustulosis Patients in Germany and the US. [PDF]

Dermatol Ther (Heidelb)
Limited information exists on the epidemiology, treatment, and burden of palmoplantar pustulosis (PPP) and defining the optimal course of treatment remains challenging without approved targeted treatments in most countries. Here, we describe the clinical
Cheng A, Deng X, Yang F, Liu C, Neasham D, Kilcoyne T, Duxbury M, Cordey M, Elewski BE.   +8 more
europepmc   +2 more sources

Associations of inflammatory cytokines with palmoplantar pustulosis: a bidirectional Mendelian randomization study. [PDF]

Front Med (Lausanne)
Background Variations in circulatory cytokine levels have been observed during the onset and course of palmoplantar pustulosis (PPP); however, whether these changes are due to etiological or secondary factors is unclear.
Liu C, Liu X, Xin H, Li X.
europepmc   +2 more sources

Exploratory Efficacy Evaluation of Apremilast for the Treatment of Japanese Patients with Palmoplantar Pustulosis: 32-Week Results from a Phase 2, Randomized, Placebo-Controlled Study. [PDF]

Dermatol Ther (Heidelb)
Palmoplantar pustulosis (PPP) is a pruritic, painful, chronic dermatitis that greatly impacts functioning and quality of life and can be difficult to treat. Approved treatment options for PPP are limited, and many patients do not fully respond to current
Okubo Y, Terui T, Kobayashi S, Sano S, Morita A, Imafuku S, Tada Y, Abe M, Yaguchi M, Kimura T, Shimauchi J, Zhang W, Amouzadeh H, Murakami M.   +13 more
europepmc   +2 more sources

Lack of association between mutation in IL36RN and palmoplantar pustular psoriasis in Chinese patients, [PDF]

Anais Brasileiros de Dermatologia, 2020
Background: Palmoplantar pustulosis is considered to be a localized pustular psoriasis confined to the palms and soles. Mutation of the IL36RN gene, encoding interleukin-36 receptor antagonist (IL-36Ra), is associated with generalized pustular psoriasis,
Yu Xiaoling, Shu Dan, Jin Hongzhong
doaj   +1 more source