Results 71 to 80 of about 5,013 (195)

A double‐blind, randomized, multicenter phase 3 study of palonosetron vs granisetron combined with dexamethasone and fosaprepitant to prevent chemotherapy‐induced nausea and vomiting in patients with breast cancer receiving anthracycline and cyclophosphamide

Cancer Medicine, 2020
Purpose To investigate whether palonosetron is better than granisetron in preventing chemotherapy‐induced nausea and vomiting (CINV) in a three‐drug combination with dexamethasone and fosaprepitant (Fos) in patients with breast cancer who are placed on ...
Koji Matsumoto, Masato Takahashi, Kazuhiko Sato, Akihiko Osaki, Toshimi Takano, Yoichi Naito, Kazuo Matsuura, Kenjiro Aogi, Kimiko Fujiwara, Kenji Tamura, Motoi Baba, Shinya Tokunaga, Gen Hirano, Shigeru Imoto, Chieko Miyazaki, Kazuhiro Yanagihara, Chiyo K. Imamura, Yasutaka Chiba, Toshiaki Saeki   +18 more
doaj   +1 more source

An Integrated In Silico and In Vivo Approach to Identify Protective Effects of Palonosetron in Cisplatin-Induced Nephrotoxicity

Pharmaceuticals, 2020
Cisplatin is widely used to treat various types of cancers, but it is often limited by nephrotoxicity. Here, we employed an integrated in silico and in vivo approach to identify potential treatments for cisplatin-induced nephrotoxicity (CIN).
Eri Wakai, Yuya Suzumura, Kenji Ikemura, Toshiro Mizuno, Masatoshi Watanabe, Kazuhiko Takeuchi, Yuhei Nishimura   +6 more
doaj   +1 more source

Effect of Modified Remote Ischemic Preconditioning on Perioperative Outcomes of CABG Patients With CPB

Journal of Cardiac Surgery, Volume 2025, Issue 1, 2025.
Objective: To investigate the effect of modified remote ischemic preconditioning (MRIC) on perioperative outcomes in patients undergoing coronary artery bypass grafting (CABG) on cardiopulmonary bypass (CPB). Methods: This study included 118 patients who planned to undergo CABG surgery at the Affiliated Hospital of Xuzhou Medical University.
Qi Sun, Xiaotong Wang, Guodong Wang, Chunyan Huan, Minjia Guo, Jie Liu, Wanling Wu, Yuanyuan Luo, Hong Zhu, Yongbo Hou, Guoxiang Wang, Defeng Pan, Piotr Mazur   +12 more
wiley   +1 more source

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 6, Page 720-742, December 2024.
Abstract Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still unidentified proton organic cation (H+/OC) antiporter is found in several tissues, including endothelial cells of the BBB.
Cauzar Ali Khan, Nicolai Kirsch, Jürgen Brockmöller, Kyra‐Elisa Maria Redeker   +3 more
wiley   +1 more source

Impact of 5-HT₃ receptor antagonists on chemotherapy-induced nausea and vomiting: a retrospective cohort study

BMC Health Services Research, 2012
Background 1st generation 5-hydroxytryptamine receptor antagonists (5-HT3 RAs), and palonosetron, a 2nd generation 5-HT3 RA, are indicated for the prevention of chemotherapy (CT)-induced nausea and vomiting (CINV) associated with moderately (MEC) and ...
Lin Swu-Jane, Hatoum Hind T, Buchner Deborah, Cox David, Balu Sanjeev   +4 more
doaj   +1 more source

Intravenous palonosetron increases the incidence of QTc prolongation during sevoflurane general anesthesia for laparotomy [PDF]

Korean Journal of Anesthesiology, 2013
BackgroundPalonosetron is a recently introduced 5-hydroxytryptamine-3 (5-HT3) receptor antagonist useful for postoperative nausea and vomiting prophylaxis.
Jeong Jin Min, Yongjae Yoo, Tae Kyong Kim, Jung-Man Lee   +3 more
doaj   +1 more source

Dezocine as preemptive analgesia alleviates ultrapulse CO2 fractional laser treatment induced pain in patients with acne scars

Journal of Cosmetic Dermatology, Volume 23, Issue 10, Page 3241-3247, October 2024.
Abstract Background Ultrapluse CO2 fractional laser technology has emerged as an effective treatment for scar management. However, one drawback of this modality is the pain caused during the procedure. This study aims to explore the efficacy and safety of dezocine (DZC) as preemptive analgesia for reduction of pain induced by ultrapulse CO2 fractional ...
Qian Zhang, Xiaoqin Li, Yuanli Wang, Ni Gao, Rongli Zhang, Jingjing Wu, Fengqin Wu, Pu Song, Min Chen, Gang Wang, Lin Gao   +10 more
wiley   +1 more source

Palonosetron for the prevention of chemotherapy-induced nausea and vomiting: approval and efficacy

Cancer Management and Research, 2009
Rudolph M NavariIndiana University School of Medicine South Bend, South Bend, IN USAAbstract: Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life.
Rudolph M Navari
doaj  

Exploring perinatal ketamine for postpartum depression following cesarean section: A systematic review

Psychiatry and Clinical Neurosciences Reports, Volume 3, Issue 3, September 2024.
Abstract The aim of this study was to explore the use of perinatal ketamine to see if it can be used for the reduction of postpartum depression (PPD) following cesarean section (C‐section). PubMed, Cochrane, and Web of Science were the primary databases used for this review.
Jaylyn Thompson, David F. Lo, Alexis Foschini, Suvan Sundaresh   +3 more
wiley   +1 more source

Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens

BMC Pharmacology and Toxicology, 2019
Background Nausea is more difficult to control than vomiting in chemotherapy. We therefore analyzed the efficacy of a strong supportive treatment with aprepitant, palonosetron, and dexamethasone against nausea for various moderately emetogenic ...
Naohisa Yoshida, Tetsuya Taguchi, Masayoshi Nakanishi, Ken Inoue, Tetsuya Okayama, Takeshi Ishikawa, Eigo Otsuji, Koichi Takayama, Haruo Kuroboshi, Motohiro Kanazawa, Yoshito Itoh   +10 more
doaj   +1 more source