Results 51 to 60 of about 2,968 (201)

5-hydroxytryptamine (5-HT) cellular sequestration during chronic exposure delays 5-HT₃ receptor resensitization due to Its subsequent release [PDF]

, 2014
The serotonergic synapse is dynamically regulated by serotonin (5-hydroxytryptamine (5-HT)) with elevated levels leading to the down-regulation of the serotonin transporter and a variety of 5-HT receptors, including the 5-HT type-3 (5-HT3) receptors.
Moffat, Christopher, Bollan, Karen A., Connolly, Christopher N., Samson, Andrew J., Alexander, Amy, Hothersall, J. Daniel   +5 more
core   +1 more source

Pharmacoeconomic analysis of the aniemetic therapy with palonosetron caps. 500 μg [PDF]

, 2012
Адрес за кореспонденция: Мария Димитрова, Фармацевтичен факултет, Медицински университет, ул. „Дунав” № 2,1000 София ***** Address for correspondence: Maria Dimitrova, Faculty of Pharmacy, Medical University, 2, Dunav Str., Bg - 1000 SofiaРезюме ...
Петрова/Petrova, Г./G., Димитрова/Dimitrova, М./M.   +1 more
core   +1 more source

Concomitant palonosetron ameliorates cisplatin-induced nephrotoxicity, nausea, and vomiting: a retrospective cohort study and pharmacovigilance analysis

Journal of Pharmaceutical Health Care and Sciences, 2022
Background Cisplatin (CDDP)-induced nephrotoxicity is the most important complication of CDDP treatment. 5-Hydroxytryptamine type 3 receptor antagonists (5-HT3RAs) are widely used to prevent chemotherapy-induced nausea and vomiting (CINV).
Miho Takemura, Kenji Ikemura, Masayoshi Kondo, Fumihiro Yamane, Mikiko Ueda, Masahiro Okuda   +5 more
doaj   +1 more source

Multi‐omics Analysis Reveals the Correlation of Gut Microbiota and Metabolites With Thalidomide Treatment for Chemotherapy‐Induced Nausea and Vomiting in Small Cell Lung Cancer

Biotechnology Journal, Volume 21, Issue 4, April 2026.
Graphical Abstract and Lay Summary We characterize the gut microbiota signatures associated with Thalidomide treatment in small cell lung cancer patients experiencing chemotherapy‐induced nausea and vomiting. The analysis reveals significant changes in specific genera, linking microbial composition to symptom management. ABSTRACT Small cell lung cancer
Qiang‐Guo Sun, Dan Zang, Yu Xin, Jia Cui, Xu Han, Jun Chen   +5 more
wiley   +1 more source

Determination of palonosetron in human urine by LC–MS/MS

, 2011
Background: Palonosetron is used for the prevention of chemotherapy-induced nausea and vomiting. However, quantification of this drug in human urine has been rare. Results: A one-step dilution method for the analysis of palonosetron in human urine using
Yongqing Wang, Ying Gu, Yuanyuan Wang, Ning Ou, Zhihong Lu, Peipei Zhang   +5 more
core   +1 more source

A randomized phase II trial of gemcitabine, nab‐paclitaxel, cisplatin with or without a medically supervised ketogenic diet for patients with metastatic pancreatic cancer

Cancer, Volume 132, Issue 6, 15 March 2026.
ABSTRACT Background A randomized phase II screening trial of gemcitabine, nab‐paclitaxel, and cisplatin with a medically supervised ketogenic diet (MSKD) versus usual diet (non‐MSKD) was conducted in patients with treatment‐naive metastatic pancreatic ductal adenocarcinoma (PDAC).
Gayle S. Jameson, Denise J. Roe, Erkut Borazanci, Diana L. Hanna, Caroline G. P. Roberts, Meredith S. Pelster, Richard C. Frank, Angela T. Alistar, Alan M. Miller, J. Erin Wiedmeier‐Nutor, Sandra D. Algaze, Alison R. Zoller, Sarah J. Hallberg, Betsy C. Wertheim, Keehoon Lee, Derek Cridebring, Joshua D. Rabinowitz, Stephen Gately, Jennifer Keppler, Sunil Sharma, Daniel D. Von Hoff, Drew W. Rasco   +21 more
wiley   +1 more source

Case Report of Acute Severe Hyponatremia Induced by Desmopressin Administration During Chemotherapy

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Patients undergoing chemotherapy are prone to developing hyponatremia due to insufficient oral intake because of nausea and vomiting, administration of large volumes of intravenous fluids, syndrome of inappropriate antidiuretic hormone secretion induced by chemotherapeutic agents, adrenal insufficiency, and drug interactions.
Koutaro Ono, Shugo Uematsu, Aya Yoshihara, Ayako Tsuboya, Shoichi Mori, Takashi Yoshioka, Shuichi Nawata   +6 more
wiley   +1 more source

Electroacupuncture for Managing Chemotherapy‐Induced Gastrointestinal Symptom Clusters in Patients With Breast Cancer: Study Protocol for a Randomized Controlled Trial

Health Care Science, Volume 5, Issue 1, Page 85-94, February 2026.
This multicenter randomized controlled trial evaluates electroacupuncture combined with standard antiemetics for managing chemotherapy‐induced gastrointestinal symptom clusters in patients with breast cancer. Integrated multi‐omics analyses aim to explore underlying mechanisms, offering potential non‐pharmacological strategies to enhance symptom ...
Xinlong Tao, Zhen Liu, Miaozhou Wang, Dengfeng Ren, Fuxing Zhao, Hongbin Wang, Guowang Yang, Ganlin Zhang, Zitao Li, Zhilin Liu, Shifen Huang, Yongzhi Chen, Mengting Da, Xiaoyan Ma, Hongxia Liang, Yongxin Li, Yinyin Ye, Yonghui Zheng, Xiao Liang, Guoshuang Shen, Xiaorong Bai, Jiuda Zhao   +21 more
wiley   +1 more source

A National Audit of Current UK Practice on the Use of Anti‐Emetics for Chemotherapy‐Induced Nausea and Vomiting in Children

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT This UK national audit aimed to assess adherence to evidence‐based chemotherapy‐induced nausea and vomiting (CINV) guidelines for children with cancer, which emphasise treatment emetogenicity assessment, symptom monitoring and appropriate antiemetic use.
Eloise Neumann, Thomas J. Jackson, Jessica E. Morgan, Robert Phillips, Jessica Bate, the CCLG Supportive Care Group   +5 more
wiley   +1 more source

Palonosetron-5-HT3Receptor Interactions As Shown by a Binding Protein Cocrystal Structure. [PDF]

, 2018
Palonosetron is a potent 5-HT3receptor antagonist and an effective therapeutic agent against emesis. Here we identify the molecular determinants of compound recognition in the receptor binding site by obtaining a high resolution structure of palonosetron

core   +2 more sources