Exploring a potential palonosetron allosteric binding site in the 5-HT 3 receptor [PDF]
, 2013 Palonosetron (Aloxi) is a potent second generation 5-HT3 receptor antagonist whose mechanism of action is not yet fully understood. Palonosetron acts at the 5-HT3 receptor binding site but recent computational studies indicated other possible sites of ...
Del Cadia M +5 more
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Impact of Palonosetron on Cough Suppression in Females Undergoing Sevoflurane-Remifentanil Anesthesia for Laparoscopic Cholecystectomy: A Randomized Trial [PDF]
, 2021 Remifentanil has been used to suppress peri-extubation cough. Palonosetron, a 5-HT3 receptor antagonist, is an effective antiemetic, and 5-HT receptors mediate the cough reflex.
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Efficacy of Palonosetron-Dexamethasone Combination Versus Palonosetron Alone for Preventing Nausea and Vomiting Related to Opioid-Based Analgesia: A Prospective, Randomized, Double-blind Trial [PDF]
, 2018 Background: The efficacy of dexamethasone plus palonosetron for postoperative nausea and vomiting (PONV) prophylaxis is not firmly established. This randomized, double-blind, controlled study evaluated whether the combination was superior to palonosetron
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Palonosetron, Dexamethasone and their combination for prevention of postoperative nausea and vomiting after laparoscopic gynecological surgeries. [PDF]
Zagazig University Medical Journal, 2021 BackgroundPalonosetron is a 5HT3 receptor antagonist which is used to prevent postoperative nausea and vomiting (PONV).DesignProspective Randomized Double Blinded Controlled Clinical Trail.Patients and methodsA total of 200 female patients of ASA ...
Nahla Amin +3 more
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Efficacy of Ondansetron Versus Palonosetron for Postoperative Nausea and Vomiting in Abdominal Laparoscopic Surgeries: A Systematic Review [PDF]
Ain Shams Medical JournalBackground: Postoperative nausea and vomiting (PONV) remain among the most common and distressing complications following abdominal laparoscopic surgeries. They significantly affect patient satisfaction, recovery time, and healthcare costs.
Krishika Verma +3 more
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Randomised Control Study of Palonosetron Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting Following Ear and Nose Surgeries under General Anesthesia [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Postoperative Nausea and Vomiting (PONV) is defined as any nausea or vomiting that occurs during the first 48 hours after surgery. It is considered as a distressing event following anaesthesia.
Anju Annie Paul +6 more
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Palonosetron has superior prophylactic antiemetic efficacy compared with ondansetron or ramosetron in high-risk patients undergoing laparoscopic surgery: a prospective, randomized, double-blinded study [PDF]
Korean Journal of Anesthesiology, 2013 BackgroundPostoperative nausea and vomiting (PONV) continues to be a major problem, because PONV is associated with delayed recovery and prolonged hospital stay.
Sung-Hoon Kim +5 more
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, 2021 Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project.
Koo, Alicia +3 more
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Seizure associated with palonosetron
Supportive Care in Cancer, 2009 In 2003, FDA approved palonosetron as an effective drug for the control ofnausea and vomitingassociated tochemotherapy. Palonosetron is suggested in case of emetogenic chemotherapy schedules, in particular, in the case of cisplatin, high-dose cyclophosphamide, and anthracyclines.
Zambelli A, Sagrada P, Pavesi L
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BMC Anesthesiology, 2019 Background Hysterectomy is a widely performed surgery and neuraxial anesthesia with intrathecal morphine provides superior quality of recovery. Postoperative nausea and vomiting (PONV) is a frequent problem with intrathecal morphine use.
Guilherme Oliveira Campos +8 more
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