Results 171 to 180 of about 13,057 (214)
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Design considerations for PAMAM dendrimer therapeutics
Bioorganic & Medicinal Chemistry Letters, 2013We have previously shown that methotrexate (MTX) conjugated to a cancer-specific poly amido amine (PAMAM) dendrimer has a higher therapeutic index than MTX alone. Unfortunately, these therapeutics have been difficult to advance because of the complicated syntheses and an incomplete understanding of the dendrimer properties.
Sascha N, Goonewardena +7 more
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2005
(MW ) (high loading beads;1 single bead analysis;2, 3 water compatible, synthesis of peptides;1-3 dendrimer-chlorambucil conjugate;3 aryl ethers;4 amidines-based GP IIb-IIa antagonists;5 benzodiazepinone derivatives;6 diketopiperazine;7 secondary amide;6 biaryl;6 tetrazole;6 site-site interactions.7) Alternate Name: DendroGel.4
Siew-Eng How, Mark Bradley
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(MW ) (high loading beads;1 single bead analysis;2, 3 water compatible, synthesis of peptides;1-3 dendrimer-chlorambucil conjugate;3 aryl ethers;4 amidines-based GP IIb-IIa antagonists;5 benzodiazepinone derivatives;6 diketopiperazine;7 secondary amide;6 biaryl;6 tetrazole;6 site-site interactions.7) Alternate Name: DendroGel.4
Siew-Eng How, Mark Bradley
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Self-assembling of DNA and PAMAM dendrimer
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005The self-assembling of DNA and cationic polymers are of interest for their biological applications. In this paper, the interaction of DNA with PAMAM was studied by agarose gel electrophoresis, size and zeta-potential measurements and circular dichroism (CD) spectroscopy. DNA was shown to form stable complexes with PAMAM by gel electrophoresis. The mean
L Z, Zhou, X L, Yang, L, Gan, H B, Xu
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Incorporation of fluorescent probes into PAMAM dendrimers
Bioelectrochemistry, 2004Interactions of two fluorescent probes 1-(trimethylammoniumphenyl)-6-phenyl-1,3,5 hexatriene p-toluenesulfonate (TMA-DPH) and 12-(9-anthroyloxy) stearic acid (12-AS) with polyamidoamine (PAMAM) dendrimers were studied. Changes in fluorescence intensity and steady-state fluorescence anisotropy of TMA-DPH and 12-AS were monitored. It was found that 12-AS
D M, Domański +2 more
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International Journal of Pharmaceutics, 2014
As a promising non-viral gene vector, cationic polyamidoamine (PAMAM) dendrimer could form complexes with negative charged DNA to mediate efficient gene delivery in vitro and in vivo. However, complicated synthesis technology and potential cytotoxicity limited their application in clinical translational researches. Hyperbranched polyamidoamine (h-PAMAM)
Yangfei, Sun +4 more
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As a promising non-viral gene vector, cationic polyamidoamine (PAMAM) dendrimer could form complexes with negative charged DNA to mediate efficient gene delivery in vitro and in vivo. However, complicated synthesis technology and potential cytotoxicity limited their application in clinical translational researches. Hyperbranched polyamidoamine (h-PAMAM)
Yangfei, Sun +4 more
openaire +2 more sources
Tetrahedron, 2006
Azide-functionalized PAMAM dendrons containing an azidopropylamine focal point were synthesized by the divergent method and applied for the construction of symmetric PAMAM-like dendrimers containing 1,2,3-triazole rings as connectors via stitching with two different multi-terminal alkynes. The stitching method was based on the click chemistry protocol,
Sung-Ho Jin, Won Suk Shin, Ji Hyeon Kim
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Azide-functionalized PAMAM dendrons containing an azidopropylamine focal point were synthesized by the divergent method and applied for the construction of symmetric PAMAM-like dendrimers containing 1,2,3-triazole rings as connectors via stitching with two different multi-terminal alkynes. The stitching method was based on the click chemistry protocol,
Sung-Ho Jin, Won Suk Shin, Ji Hyeon Kim
exaly +2 more sources
Application of PAMAM dendrimers in optical sensing
The Analyst, 2015In this review, recent advances have been reported in those PAMAM dendrimer-based optical sensors that are used for the detection of pH, cations, and other analyte.
E, Soršak +3 more
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Au(III)–PAMAM Interaction and Formation of Au–PAMAM Nanocomposites in Ethyl Acetate
Journal of Colloid and Interface Science, 2001Abstract The interaction of tetrachloroauric anion (AuCl4−) and hydrophobic poly(amidoamine) dendrimers (PAMAM) with terminal methyl ester groups was investigated in ethyl acetate by UV–vis and IR spectroscopies. Three possible types of interaction are suggested: (a) ion pair formation between AuCl4− and protonated tertiary amine of PAMAM, (b ...
Kanjiro Torigoe +2 more
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Bioconjugate Chemistry, 2007
A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM ...
Jae Wook, Lee +6 more
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A new convergent synthetic method for the synthesis of PAMAM dendrimers has been developed. The fusion between propargyl-functionalized PAMAM dendrons and azido-functionalized PAMAM dendrons via the Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction (click chemistry) of an alkyne and an azide leads to the formation of symmetric PAMAM ...
Jae Wook, Lee +6 more
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The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers
Biomaterials, 2014Poly(amidoamine) (PAMAM) dendrimers, are among the most common classes of dendrimers that are intended for a wide range of biomedical applications and extensively investigated for brain-specific drug delivery, imaging and diagnosis. Unfortunately, neurotoxicity of PAMAM dendrimers, the underlying mechanism of which is poorly-elucidated, poses a far ...
Ping Song, Xian Zeng, Yun Sun
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