Results 151 to 160 of about 7,907 (187)

PAMAM-PEG-PAMAM: Novel Triblock Copolymer as a Biocompatible and Efficient Gene Delivery Carrier

Biomacromolecules, 2004
A novel triblock copolymer, PAMAM-block-PEG-block-PAMAM was synthesized and applied as a gene carrier. PAMAM dendrimer is proven to be an efficient gene carrier itself, but it is associated with certain problems such as low water solubility and considerable cytotoxicity.
Tae-Il, Kim, Hyo Jung, Seo, Joon Sig, Choi, Hyung-Suk, Jang, Jung-Un, Baek, Kwan, Kim, Jong-Sang, Park   +6 more
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Incorporation of fluorescent probes into PAMAM dendrimers

Bioelectrochemistry, 2004
Interactions of two fluorescent probes 1-(trimethylammoniumphenyl)-6-phenyl-1,3,5 hexatriene p-toluenesulfonate (TMA-DPH) and 12-(9-anthroyloxy) stearic acid (12-AS) with polyamidoamine (PAMAM) dendrimers were studied. Changes in fluorescence intensity and steady-state fluorescence anisotropy of TMA-DPH and 12-AS were monitored. It was found that 12-AS
D M, Domański, B, Klajnert, M, Bryszewska   +2 more
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Self-assembling of DNA and PAMAM dendrimer

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, 2005
The self-assembling of DNA and cationic polymers are of interest for their biological applications. In this paper, the interaction of DNA with PAMAM was studied by agarose gel electrophoresis, size and zeta-potential measurements and circular dichroism (CD) spectroscopy. DNA was shown to form stable complexes with PAMAM by gel electrophoresis. The mean
L Z, Zhou, X L, Yang, L, Gan, H B, Xu
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Design considerations for PAMAM dendrimer therapeutics

Bioorganic & Medicinal Chemistry Letters, 2013
We have previously shown that methotrexate (MTX) conjugated to a cancer-specific poly amido amine (PAMAM) dendrimer has a higher therapeutic index than MTX alone. Unfortunately, these therapeutics have been difficult to advance because of the complicated syntheses and an incomplete understanding of the dendrimer properties.
Sascha N, Goonewardena, Jeremy D, Kratz, Hong, Zong, Ankur M, Desai, Shengzhuang, Tang, Sarah, Emery, James R, Baker, Baohua, Huang   +7 more
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Au(III)–PAMAM Interaction and Formation of Au–PAMAM Nanocomposites in Ethyl Acetate

Journal of Colloid and Interface Science, 2001
Abstract The interaction of tetrachloroauric anion (AuCl4−) and hydrophobic poly(amidoamine) dendrimers (PAMAM) with terminal methyl ester groups was investigated in ethyl acetate by UV–vis and IR spectroscopies. Three possible types of interaction are suggested: (a) ion pair formation between AuCl4− and protonated tertiary amine of PAMAM, (b ...
Kanjiro Torigoe, Akihiro Suzuki, Kunio Esumi   +2 more
openaire   +1 more source

Synthesis and characterization of immobilized PAMAM dendrons

Chemical Communications, 2007
This communication describes the synthesis and characterization of immobilized PAMAM dendrons onto a surface modified silicon wafer substrate (functionalized using plasma polymerized PAA) using a 'growing from' strategy.
Pollock, Neal, Fowler, Greg, Twyman, Lance J., McArthur, Sally L.   +3 more
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Application of PAMAM dendrimers in optical sensing

The Analyst, 2015
In this review, recent advances have been reported in those PAMAM dendrimer-based optical sensors that are used for the detection of pH, cations, and other analyte.
E, Soršak, J Volmajer, Valh, Š Korent, Urek, A, Lobnik   +3 more
openaire   +2 more sources

The strategy to improve gene transfection efficiency and biocompatibility of hyperbranched PAMAM with the cooperation of PEGylated hyperbranched PAMAM

International Journal of Pharmaceutics, 2014
As a promising non-viral gene vector, cationic polyamidoamine (PAMAM) dendrimer could form complexes with negative charged DNA to mediate efficient gene delivery in vitro and in vivo. However, complicated synthesis technology and potential cytotoxicity limited their application in clinical translational researches. Hyperbranched polyamidoamine (h-PAMAM)
Yangfei, Sun, Yunfeng, Jiao, Yang, Wang, Daru, Lu, Wuli, Yang   +4 more
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PAMAM Dendrimer Resins

2005
(MW ) (high loading beads;1 single bead analysis;2, 3 water compatible, synthesis of peptides;1-3 dendrimer-chlorambucil conjugate;3 aryl ethers;4 amidines-based GP IIb-IIa antagonists;5 benzodiazepinone derivatives;6 diketopiperazine;7 secondary amide;6 biaryl;6 tetrazole;6 site-site interactions.7) Alternate Name: DendroGel.4
Siew-Eng How, Mark Bradley
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Toxicity of PAMAM dendrimers to Chlamydomonas reinhardtii

Aquatic Toxicology, 2010
In recent decades, a new class of polymeric materials, PAMAM dendrimers, has attracted marked interest owing to their unique nanoscopic architecture and their hopeful perspectives in nanomedicine and therapeutics. However, the potential release of dendrimers into the aquatic environment raises the issue about their toxicity on aquatic organisms.
Anne-Noëlle, Petit, Philippe, Eullaffroy, Timothée, Debenest, François, Gagné   +3 more
openaire   +2 more sources