Results 81 to 90 of about 19,804 (212)

Charged dendrimers revisited: Effective charge and surface potential of dendritic polyglycerol sulfate

, 2017
We investigate key electrostatic features of charged dendrimers at hand of the biomedically important dendritic polyglycerol sulfate (dPGS) macromolecule using multi-scale computer simulations and Zetasizer experiments.
Ballauff, Matthias, Dzubiella, Joachim, Haag, Rainer, Ran, Qidi, Xu, Xiao   +4 more
core   +1 more source

The Effect of Absorption-Enhancement and the Mechanism of the PAMAM Dendrimer on Poorly Absorbable Drugs

Molecules, 2018
The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0–G3) and concentrations (0 ...
Juan Lu, Nannan Li, Yaochun Gao, Nan Li, Yifei Guo, Haitao Liu, Xi Chen, Chunyan Zhu, Zhengqi Dong, Akira Yamamoto   +9 more
doaj   +1 more source

Interactions of Poly(amidoamine) Dendrimers with Human Serum Albumin: Binding Constants and Mechanisms [PDF]

, 2011
The interactions of nanomaterials with plasma proteins have a significant impact on their in vivo transport and fate in biological fluids. This article discusses the binding of human serum albumin (HSA) to poly(amidoamine) [PAMAM] dendrimers.
Diallo, Mamadou S., Giri, Jyotsnendu, Goddard, William A., III, Kumar, Rajeev, Liu, Yi, Simpson, André J., Woods, Gwen C.   +6 more
core   +1 more source

Microchip electrophoresis bioanalytical applications [PDF]

, 2008
Microchip electrophoresis (MCE) is a novel analytical technique resulting from miniaturization of capillary electrophoresis (CE) to a planar microfabricated separation device.
Vlcková, Markéta
core   +1 more source

Surface engineered carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles for intracellular targeting [PDF]

, 2008
Novel highly branched biodegradable macromolecular systems have been developed by grafting carboxymethylchitosan (CMCht) onto low generation poly(amidoamine) (PAMAM) dendrimers.
Benesch, Johan, Costa, Silgia, Hajime, Ohgushi, Hirose, Motohiro, Kotobuki, Noriko, Mano, J. F., Marques, A. P., Oliveira, Joaquim M., Pirraco, Rogério, Reis, R. L.   +9 more
core   +1 more source

PAMAM: Power analysis in multiancestry admixture mapping

Genetic Epidemiology, 2019
AbstractAdmixed populations arise when two or more previously isolated populations interbreed. Admixture mapping (AM) methods are used for tracing the ancestral origin of disease‐susceptibility genetic loci in the admixed population such as African American and Latinos.
Yadu Gautam, Sudhir Ghandikota, Siqi Chen, Tesfaye B. Mersha   +3 more
openaire   +3 more sources

Preparation and effect research of non-ionic demulsifiers for polymer-containing wastewater

Gongye shui chuli
A demulsification strategy based on hyperbranched non-ionic polyamide amine(h-PAMAM) was proposed to address the stability mechanism and demulsification bottleneck of polymer-containing wastewater systems, aiming to achieve dual goals of efficient oil ...
WANG Qingji, YANG Xueying, ZHANG Zejun, PEI Maochen, WANG Qinghong, SHI Quan, CHEN Chunmao   +6 more
doaj   +1 more source

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source

PAMAM Dendrimers as Promising Nanocarriers for RNAi Therapeutics [PDF]

, 2015
Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging.
Amin, Mohd Cairul Iqbal Mohd, Banerjee, Sanjeev, Gupta, Umesh, Iyer, Arun K., Kesharwani, Prashant, Padhye, Subhash, Sarkar, Fazlul H.   +6 more
core   +2 more sources

Origin of broad polydispersion in functionalized dendrimers and its effects on cancer cell binding affinity

, 2010
Nanoparticles with multiple ligands have been proposed for use in nanomedicine. The multiple targeting ligands on each nanoparticle can bind to several locations on a cell surface facilitating both drug targeting and uptake.
Bradford G. Orr, D. Weitman, Douglas G. Mullen, G. D. Titskii, Jack N. Waddell, Leonard M. Sander, Mark M. Banaszak Holl, X. Wang   +7 more
core   +1 more source