Results 101 to 110 of about 823,779 (195)

Oxypaeoniflorin Attenuates Alcohol‐Associated Liver Disease, Potentially Involving TEAD4‐Mediated Inflammatory Signaling Cascades

Phytotherapy Research, EarlyView.
Oxypaeoniflorin (Opae) alleviates alcohol‐associated liver disease (ALD) by suppressing the TEAD4‐NLRP3 transcriptional axis. In hepatocytes, Opae inhibits YAP/TEAD4‐mediated NLRP3 inflammasome activation, thereby downregulating Lipin1/Srebp1‐associated lipid dysregulation.
Jiang‐Tao Zhong, Hao Yue, Ze‐Hao Wang, Ming Liu, Hai‐Ming Sun, Jian Song   +5 more
wiley   +1 more source

Programmable Plant Immunity: Synthetic Biology for Climate-Resilient Agriculture

SynBio
Agricultural systems face mounting pressures from climate change, as rising temperatures, elevated CO2, and shifting precipitation patterns intensify plant disease outbreaks worldwide. Conventional strategies, such as breeding for resistance, pesticides,
Sopan Ganpatrao Wagh, Akshay Milind Patil, Ghanshyam Bhaurao Patil, Sachin Ashok Bhor, Kiran Ramesh Pawar, Harshraj Shinde   +5 more
doaj   +1 more source

Tangeretin Targets Macrophage M1 Polarization to Alleviate Liver Injury in a Murine Model of Hepatic Sinusoidal Obstruction Syndrome

Phytotherapy Research, EarlyView.
Tangeretin (TAN) alleviates monocrotaline‐induced hepatic sinusoidal obstruction syndrome in mice. By attenuating the Keap1–Nrf2 interaction, TAN promotes Nrf2 nuclear translocation and mitophagy, thereby preserving mitochondrial homeostasis and reducing mitochondrial reactive oxygen species.
Fumin Zhang, Cheng Zhu, Xingyu Li, Tianyin Sun, Yongkang Zhang, Mengwei Wu, Qianqian Zhang, Ying Dai, Xuecan Mei, Derun Kong   +9 more
wiley   +1 more source

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

In Vitro and In Vivo Immunomodulatory and Protective Effects of Leukemia Inhibitory Factor‐Engineered Mesenchymal Stromal Cells in Experimental Endotoxemia

Microbiology and Immunology, EarlyView.
ABSTRACT Sepsis is a life‐threatening condition characterized by dysregulated systemic inflammation and high mortality rates. Mesenchymal stem/stromal cells (MSCs) have emerged as promising immunomodulatory agents; however, genetic engineering strategies can enhance their therapeutic efficacy.
Alana Costa de Oliveira, Diego de Carvalho Carneiro, Luiza Carolina França Opretzka, Breno Cardim Barreto, Dahara Keyse Carvalho Silva, Girlaine Café Santos, Cássio Santana Meira, Milena Botelho Pereira Soares   +7 more
wiley   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Ca2+ and ROS signalling exhibit divergent root-specific dynamics in Arabidopsis responses to abiotic stress and PAMPs

Current Plant Biology
Plant resilience relies on detecting and responding to osmotic stress and pathogens. Calcium (Ca2+) and hydrogen peroxide (H2O2) are key signalling molecules in plant stress, yet their interplay with protein modifications remains unclear.
Claudia Allan, Evelyne Maes, Ancy Thomas, Charles Hefer, Wenting Liu, Liadan Dickie, Volker Nock, Claudia-Nicole Meisrimler   +7 more
doaj   +1 more source

Pathogenic Airway Bacteria and Local Immune Responses During Early‐Life Asthma‐Like Episodes

Allergy, EarlyView.
This study investigates how Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis associate with airway immune responses during early‐life asthma‐like episodes, and compare these responses between children with and without asthma.
Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann‐Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard   +12 more
wiley   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source