Results 111 to 120 of about 686,190 (235)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

High‐Sugar Diet and Intestinal Diseases: A Shared Microbiota–Barrier–Immunity–Metabolism Axis in Inflammatory Bowel Disease, Food Allergy, and Colorectal Cancer

iNew Medicine, EarlyView.
ABSTRACT The global incidence of intestinal diseases—including food allergy, inflammatory bowel disease (IBD), and colorectal cancer (CRC)—continues to escalate in parallel with the expansion of the “Western diet,” within which the high‐sugar diet (HSD) has emerged as a pivotal yet under‐recognized dietary driver.
Yuchen Wang, Yajuan Wu, Huayang Sheng, Shouhong Jiang, Jinping Cheng, Ye Kuang, Miao Liu, Lei Feng, Yanan Sun, Jinzhi Duan   +9 more
wiley   +1 more source

Toll‐Like Receptors in the Mechanism of Hexabromocyclododecane‐Induced Production of Pro‐Inflammatory Cytokines

Journal of Applied Toxicology, EarlyView.
ABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Wenjun Zhu, Aleshia Seaton‐Terry, Brian Townsend, Zinia Hunter, April Falconer‐Turner, Syeda Raika Shahid, Margaret Whalen   +6 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Ca2+ and ROS signalling exhibit divergent root-specific dynamics in Arabidopsis responses to abiotic stress and PAMPs

Current Plant Biology
Plant resilience relies on detecting and responding to osmotic stress and pathogens. Calcium (Ca2+) and hydrogen peroxide (H2O2) are key signalling molecules in plant stress, yet their interplay with protein modifications remains unclear.
Claudia Allan, Evelyne Maes, Ancy Thomas, Charles Hefer, Wenting Liu, Liadan Dickie, Volker Nock, Claudia-Nicole Meisrimler   +7 more
doaj   +1 more source

Signalling of Arabidopsis thaliana response to Pieris brassicae eggs shares similarities with PAMP-triggered immunity [PDF]

, 2017
Insect egg deposition activates plant defence, but very little is known about signalling events that control this response. In Arabidopsis thaliana, oviposition by Pieris brassicae triggers salicylic acid (SA) accumulation and induces the expression of ...
Gouhier-Darimont, Caroline, Reymond, Philippe, Schmiesing, André, Lassueur, Steve, Bonnet, Christelle   +4 more
core  

Deciphering plant–pathogen interaction with single‐cell omics

New Plant Protection, EarlyView.
Recent advances in single‐cell omics have enabled the decoding of gene regulatory networks at the cellular resolution during pathogen challenge. This review summarizes the technological developments in plant single‐cell omics and highlights their unique advantages for dissecting nearly all stages of plant–pathogen interactions, including initial ...
Lu Gan, Wenwen Liu, Syed S. Zaidi, Huaibing Jin   +3 more
wiley   +1 more source

NRG1-mediated recognition of HopQ1 reveals a link between PAMP- and Effector-triggered Immunity

, 2018
SummaryMembers of the hopQ1/XopQ family of effectors are conserved amongst pathogenic bacteria suggesting an important function in virulence. Therefore, the identification of R proteins recognising members of this family is potentially of high value to ...
Erik H. A. Rikkerink, Marcela Martinez-Sanchez, Cyril Brendolise, Ronan Chen, Nemo Peeters, Simon Deroles, Arry Morel, Romain Dinis, Mirco Montefiori   +8 more
core   +1 more source

Harnessing plant susceptibility genes into strategies for enhanced disease resistance

New Plant Protection, EarlyView.
Integrated model of S gene modules in plant pathogen interactions. This model summarises representative host susceptibility modules that can be exploited by bacterial, fungal and viral pathogens. In the bacterial infection module, Xanthomonas transcription activator‐like effectors activate OsSWEET14 through effector‐binding elements in its promoter ...
Can Chen, Yuzhe Shi, Hanwen Miao, Ning Wang, Xiaojie Wang   +4 more
wiley   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source