Results 141 to 150 of about 823,779 (195)
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Periodontitis and metabolic dysfunction‐associated steatotic liver disease
Periodontology 2000, EarlyView.Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon +6 more
wiley +1 more source
Metabolic reprogramming of the immune response in periodontitis
Periodontology 2000, EarlyView.Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon +3 more
wiley +1 more source
Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases
Periodontology 2000, EarlyView.Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach +5 more
wiley +1 more source
Vox Sanguinis, EarlyView.Abstract Background and Objectives Growth of gram‐negative bacteria in a platelet concentrate (PC) is inevitably accompanied by the accumulation of endotoxin, which is the major component of the outer cell membrane of these organisms. However, less is known about the kinetics of endotoxin accumulation in PC and its biological activity.
Marcel Prax +14 more
wiley +1 more source
Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury
Experimental Physiology, EarlyView.Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley +1 more source
Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation
The Journal of Physiology, EarlyView.Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min +2 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 6, December 2026.Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou +5 more
wiley +1 more source
The Plant Genome, Volume 19, Issue 4, December 2026.Abstract Harmful T‐2 and HT‐2 mycotoxins are produced by Fusarium langsethiae and Fusarium sporotrichioides in developing oat (Avena sativa L.) grain. This study identified oat genotypes with consistently low toxin accumulation across environments. Toxin enzyme‐linked immunosorbent assay and fungal DNA (quantitative polymerase chain reaction) levels ...
Farhana Afroze +8 more
wiley +1 more source
MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Immunology, Volume 179, Issue 4, Page 537-553, December 2026.MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula +6 more
wiley +1 more source