Results 131 to 140 of about 52,994 (295)

Unexpected effect of tetraglyme plasticizer on lithium ion dynamics in PAMPS based ionomers

, 2016
Li+ cation conducting ionomers based on poly(2-acrylamido-2-methyl-1-propanesulphonic acid) (PAMPS) incorporating a low molecular weight plasticizer have been characterized.
YV Oza (14543840), Luke O'Dell (13081899), DR MacFarlane (14463342), Maria Forsyth (13084584)   +3 more
core  

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Synthesis of Diblock Polyampholyte PAMPS-b-PMAPTAC and Its Adsorption on Bentonite

, 2018
To study the adsorption of polyampholyte on bentonite (Bent), a block polyampholyte, PAMPS-b-PMAPTAC, comprised of 2-Acrylamido-2-Methylpropane Sulfonic Acid (AMPS) units and Methacrylamido Propyl Trimethyl Ammonium Chloride (MAPTAC) units, was ...
Ling Lin, Xin Li, Yuanhao Luo
core   +1 more source

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

Cell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu, Bingyu Cai, Tingting Gao, Wumei Wei, Liu Wang, Qi Zhou, Wei Li, Jie Hao, Jun Wu   +8 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Interação entre Lipoxina A4 (LXA4) e Padrões Moleculares Associados a Patógenos (PAMPs) de Streptococcus pneumoniae: análise in silico por bioinformática [PDF]

Streptococcus pneumoniae is a gram-positive diplococcus bacterium that colonizes the human nasopharynx and is one of the main causes of pneumonia. S.
Santana, Mayume Martins
core  

Aerobic Exercise Training Increases Circulating sRAGE in Adults With Type 2 Diabetes: Associations With Sheddase Regulation

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins, Corey E. Mazo, James Shadiow, Pallavi Varshney, Edwin R. Miranda, Victoria R. Miranda, Maggie Eisenberg, Jane E. Nakamura, Elif A. Oral, Jacob M. Haus   +9 more
wiley   +1 more source

Biological activity of soluble PAMPs present in normal human faeces.

, 2013
(A) RAW macrophages were challenged with 1, 10 or 100 µg/ml SFE of six healthy subjects and TNF-α was measured at 4 h. Mean +/− SD shown. (B) RAW macrophages were challenged with 20 µg/ml sterile-filtered extract (SFE) of 5 healthy human volunteers ...
Clett Erridge (367230), Markus M. Heimesaat (32396), Sylvia H. Duncan (125296), Stefan Bereswill (32410)   +3 more
core   +1 more source

Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link

The FEBS Journal, EarlyView.
Human RNase 7 is known to exert antimicrobial activity in epithelial tissues. Here, using SH‐SY5Y and U‐87 MG, neuroblastoma and glioblastoma cell lines, respectively, we found that RNase 7 enhances immune responses to LPS stimulation by reducing the expression of pro‐inflammatory cytokines, nitric oxide, and ROS.
Rosanna Culurciello, Maria Cristiano, Ilaria Di Nardo, Ida Palumbo, Erika Piccolo, Rosario Oliva, Andrea Bosso, Aldo Donizetti, Eugenio Notomista, Elio Pizzo   +9 more
wiley   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source