Results 221 to 230 of about 52,994 (295)

Pattern recognition receptor signaling in otitis media: immune crosstalk and pathogenic mechanisms. [PDF]

Front Immunol
Guo M, Zhang S, Liao Z, Yan D, Tan X, Liu C.   +5 more
europepmc   +1 more source

Dietary Polyphenols as Natural Modulators of NF‐κB Signaling in Inflammation‐Driven Non‐Communicable Diseases: Focus on Cancer

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Dietary polyphenols and phytochemicals suppress NF‐κB signaling. Mechanistically, by inhibiting IκBα degradation and preventing nuclear translocation of p65/p50 complexes, the polyphenols reduce the expression of pro‐inflammatory and pro‐survival genes, thereby decreasing overall cancer cell survival.
Khuzin Dinislam, Anas Shamsi, Syed Tasqeruddin, Moyad Shahwan   +3 more
wiley   +1 more source

Programmable somatosensory soft robots. [PDF]

Npj Flex Electron
Georgopoulou A, Aguiriano Calvo M, Lucherini L, Lee S, Hughes J, Amstad E.   +5 more
europepmc   +1 more source

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

Innate immune sensing of alphavirus chikungunya: balancing antiviral defense and pathogenesis. [PDF]

Front Immunol
da Silva JSF, Ferreira Junior CV, Dos Santos LMS, de Andrade-Neto VF, Guedes PMDM, Yaochite JNU, França RFO, Brito RMM, Nascimento MSL.   +8 more
europepmc   +1 more source

Tricarboxylic Acid (TCA) Cycle Enzyme Alpha‐Ketoglutarate Dehydrogenase (KGDH) as a Nexus for the Regulation of Macrophage Polarization

Journal of Cellular Biochemistry, Volume 127, Issue 7, July 2026.
ABSTRACT Macrophage metabolism has been increasingly studied in recent years for its potential as a therapeutic target across multiple pathologies. In this article, we propose that the tricarboxylic acid (TCA) cycle enzyme alpha‐ketoglutarate (KG) dehydrogenase (KGDH) serves as a nexus for regulating macrophage polarization toward pro‐inflammatory (M1)
Meijing Li, Ryan J. Mailloux
wiley   +1 more source

Pathophysiological mechanisms of post-exertional malaise: an integrative analysis based on the metabolism-immune-neuro interaction model. [PDF]

Front Immunol
Jin H, An Y, Huang J, Luo T, Wu X.
europepmc   +1 more source

miR‐19a‐3p and miR‐19b‐3p Promote Microglia Activation Associated With Neuroinflammation

Journal of Neuroscience Research, Volume 104, Issue 7, July 2026.
miR19a and miR19b enhance microglia activation. ABSTRACT Neuroinflammation, driven by microglia activation and the production of pro‐inflammatory cytokines, has been implicated in several neurological diseases and neuropathic pain. MicroRNAs (miRNAs) have emerged as important regulators of neuroinflammatory processes.
Faezeh Sahebdel, Ricardo A. Battaglino, Leslie R. Morse, Julie K. Olson   +3 more
wiley   +1 more source

From dysbiosis to malignancy: decoding gut-driven pathways to clinical management in hepatocellular carcinoma. [PDF]

Front Cell Infect Microbiol
Ismaiel A, Almonajjed MB, Wardeh M, Abdelghafar A, Popa SL, Sabo C, Dumitrascu DL.   +6 more
europepmc   +1 more source

Coronavirus M Protein Hijacks Toll‐Interacting Protein (TOLLIP) to Suppress NF‐κB Signaling and Promote Immune Evasion

MedComm, Volume 7, Issue 7, July 2026.
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang, Lu Kang, Yu Zhong, Songjun Shao, Senren Xue, Changliang Liu, Xiaoqi Zheng, Jing‐Wen Lin, Yu Chen, Fengming Luo, Huajing Wan   +10 more
wiley   +1 more source