Results 141 to 150 of about 3,191,959 (309)

Immunomediated Pan-cancer Regulation Networks are Dominant Fingerprints After Treatment of Cell Lines with Demethylation

, 2016
Pan-cancer studies are particularly relevant not only for addressing the complexity of the inherently observed heterogeneity but also for identifying clinically relevant features that may be common to the cancer types.
Manama El Baroudi, Enrico Capobianco, Caterina Cinti, Mariama El Baroudi   +3 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC TARGETS

, 2017
PAN-CANCER PROFILES OF BRAIN METASTASES: PRIORITIZATION OF THERAPEUTIC ...
Raymond Sawaya (2227282), Priscilla K Brastianos (12250445), Waldemar Priebe (205036), David Spetzler (2647915), Huang Suyun (13470418), Sherise Ferguson (13470409), Shouhao Zhou (7349000), Jianjun Zhang (220300), Joseph McCarty (156514), Roel Verhaak (9621999), Isabella Glitza (5844953), John Heymach (13470424), John de Groot (532812), Jethro Hu (328052), Nuhad Ibrahim (5106983), Michael Salacz (13470412), Amy Heimberger (13470430), Joanne Xiu (5024744), Siyuan Zheng (532810), Mustafa Khasraw (13078896), Sandeep Reddy (2629234), Santosh Kesari (248499), David Piccioni (13470415), Micheal Davies (13470421), Jeremy Rudnick (328053), Barbara J O'Brien (13470427)   +25 more
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Obstetrics and gynaecology: one specialty or two?

Journal of Obstetrics and Gynaecology, 2023
Ayman A. A. Ewies
doaj   +1 more source

Long Intergenic Non-Coding RNAs and BRCA1 in Breast Cancer Pathogenesis: Neighboring Companions or Nemeses?

Non-Coding RNA
Breast cancer is one of the leading causes of mortality among women, primarily due to its complex molecular landscape and heterogeneous nature. The tendency of breast cancer patients to develop metastases poses significant challenges in clinical ...
Olalekan Olatunde Fadebi, Thabiso Victor Miya, Richard Khanyile, Zodwa Dlamini, Rahaba Marima   +4 more
doaj   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

A pan-cancer atlas [PDF]

Nature Methods, 2018
openaire   +2 more sources

Expression and immunological role of FUNDC2 in pan-cancer

PLOS One
FUNDC2 is a novel mitochondrial protein and is highly involved in various cancers. However, expression pattern and possible role and mechanism of FUNDC2 in pan-cancer remain to be investigated. TIMER 2.0 was used to investigate the expression patterns and immune infiltration of FUNDC2. GEPIA was applied to study the relationship between level of FUNDC2
Xirong Qiu, Shuyu Wang, Chenlu Li, Yinan Wang   +3 more
openaire   +3 more sources

Archiwum Danych Jakościowych przy IFiS PAN

, 2019
This text contains information about the Qualitative Data Archive at the Institute of Philosophy and Sociology PAS (QDA) [Archiwum Danych Jakościowych przy IFiS PAN — ADJ; adj.ifispan.pl], which collects and digitalizes databases from a broad range of ...
, Zespół Archiwum Danych Jakościowych przy IFiS PAN
core