Results 271 to 280 of about 3,191,959 (309)

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Pan-cancer characterization of POSTN and its clinical and microenvironmental associations in ER⁺ breast cancer. [PDF]

Sci Rep
Zhai X, Yeerkenbieke B, Yeerxiati D, Chen Y, Zhang H, Diao Z, Wang J, Zhang Y, Guo W.   +8 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

AI-Guided SERS Defines a Pan-Cancer Diagnostic Biomarker. [PDF]

Adv Sci (Weinh)
Zhang C, Zhao WH, Zuo D, Zhou T, Hou W, Wang L, Shi S, Yang Y, Liu Y, Sun SK, Ren L, Ye Z, Liu D, Li D, Chen X, Hao J.   +15 more
europepmc   +1 more source

Panorama: a database for the oncogenic evaluation of somatic mutations in pan-cancer. [PDF]

Database (Oxford)
Park SJ, Kim SY.
europepmc   +1 more source

A Cytokine-Related Gene Signature for Pan-Cancer Prognostic Stratification and Malignant Phenotype Characterization. [PDF]

Int J Mol Sci
Chen SC, Chang KF, Chao CC, Lin CH, Chang CH, Ko CC, Lin HR, Wu CJ, Yuan CH, Kumar S, Solomon DD, Xuan DTM, Palekkode N, Fathima A, Waikhom J, Wang CY, Lee YK, Liu HP.   +17 more
europepmc   +1 more source

Pan-cancer analysis reveals the prognostic and therapeutic relevance of MEX3A with a focus on chromophobe renal cell carcinoma. [PDF]

Front Oncol
Wang S, Zhang J, Zheng M, Feng Y, Li T.
europepmc   +1 more source