Results 101 to 110 of about 174,716 (299)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

The goat pan-genome reveals patterns of gene loss during domestication

Journal of Animal Science and Biotechnology
Background Unveiling genetic diversity features and understanding the genetic mechanisms of diverse goat phenotypes are pivotal in facilitating the preservation and utilization of these genetic resources.
Jiaxin Liu, Yilong Shi, Dongxin Mo, Lingyun Luo, Songsong Xu, Fenghua Lv   +5 more
doaj   +1 more source

Genomic analysis of three African strains of Bacillus anthracis demonstrates that they are part of the clonal expansion of an exclusively pathogenic bacterium

New Microbes and New Infections, 2014
Bacillus anthracis is the causative agent of anthrax and is classified as a ‘Category A’ biological weapon. Six complete genomes of B. anthracis (A0248, Ames, Ames Ancestor, CDC684, H0491, and Sterne) are currently available. In this report, we add three
L. Rouli, M. Mbengue, C. Robert, M. Ndiaye, B. La Scola, D. Raoult   +5 more
doaj   +1 more source

Campylobacter species in dogs and cats and significance to public health in New Zealand : a thesis in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Veterinary Science at Massey University, Palmerston North, New Zealand [PDF]

, 2016
Campylobacter spp. are a major cause of bacterial gastroenteritis in people in the developed world, including New Zealand. Many sources and transmission routes exist, as these bacteria are common in animals and the environment. C.
Bojanić, Krunoslav
core  

Microevolution during the emergence of a monophasic Salmonella Typhimurium epidemic in the United Kingdom [PDF]

, 2016
Microevolutionary events associated with the emergence and clonal expansion of new 27 epidemic clones of bacterial pathogens hold the key to understanding the drivers of 28 epidemiological success.
A. Underwood, Alison E. Mather, Allison, Anderson, Andrew Page, Antonia A. Lettini, Barone, de la Torre, European Food Safety Authority, Friebel, Gordon Dougan, Hardt, Hauser, Hopkins, Hughes, John Wain, Julian Parkhill, K.L. Hopkins, Laorden, Liljana Petrovska, Majowicz, Manal AbuOun, Mary Bagnall, Mather, Medardus, Mossong, Nicholson, Okoro, Page, Priscilla Branchu, Rabsch, Robert A. Kingsley, Robert Davies, Simon R. Harris, Slade, Soyer, Switt, Thomas Connor, Threlfall, Threlfall, Trüpschuch, Wood   +41 more
core   +3 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

The pan-genome of Lactobacillus reuteri strains originating from the pig gastrointestinal tract [PDF]

, 2015
Background Lactobacillus reuteri is a gut symbiont of a wide variety of vertebrate species that has diversified into distinct phylogenetic clades which are to a large degree host-specific.
Crossman, Lisa C., Goesmann, Alexander, Juge, Nathalie, Mackenzie, Donald A., Roos, Stefan, Swarbreck, David, Walter, Jens, Wegmann, Udo, Zheng, Jinshui   +8 more
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Genome Sequence of Corynebacterium pseudotuberculosis MB20 bv. equi Isolated from a Pectoral Abscess of an Oldenburg Horse in California. [PDF]

, 2014
The genome of Corynebacterium pseudotuberculosis MB20 bv. equi was sequenced using the Ion Personal Genome Machine (PGM) platform, and showed a size of 2,363,089 bp, with 2,365 coding sequences and a GC content of 52.1%.
Azevedo, Vasco, Baraúna, Rafael A, Benevides, Leandro J, Carneiro, Adriana R, de Sá, Pablo HCG, Edman, Judy M, Folador, Edson L, Graças, Diego A, Guimarães, Luís C, Pinheiro, Kenny C, Ramos, Rommel TJ, Schneider, Maria PC, Silva, Andreia SS, Silva, Artur, Spier, Sharon J, Veras, Adonney AO, Viana, Marcus VC   +16 more
core   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source