Results 101 to 110 of about 171,414 (293)

Application of Comparative Genomics for the Development of PCR Primers for the Detection of Harmful or Beneficial Microorganisms in Food: Mini-Review

Foods
Gene markers are widely utilized for detecting harmful and beneficial microorganisms in food products. Primer sequences targeting the 16S rRNA region, recognized as a conserved region, have been conventionally employed in PCR analyses.
Sang-Soon Kim
doaj   +1 more source

HUPAN: a pan-genome analysis pipeline for human genomes

Genome Biology, 2019
The human reference genome is still incomplete, especially for those population-specific or individual-specific regions, which may have important functions. Here, we developed a HUman Pan-genome ANalysis (HUPAN) system to build the human pan-genome.
Zhongqu Duan, Yuyang Qiao, Jinyuan Lu, Huimin Lu, Wenmin Zhang, Fazhe Yan, Chen Sun, Zhiqiang Hu, Zhen Zhang, Guichao Li, Hongzhuan Chen, Zhen Xiang, Zhenggang Zhu, Hongyu Zhao, Yingyan Yu, Chaochun Wei   +15 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

The goat pan-genome reveals patterns of gene loss during domestication

Journal of Animal Science and Biotechnology
Background Unveiling genetic diversity features and understanding the genetic mechanisms of diverse goat phenotypes are pivotal in facilitating the preservation and utilization of these genetic resources.
Jiaxin Liu, Yilong Shi, Dongxin Mo, Lingyun Luo, Songsong Xu, Fenghua Lv   +5 more
doaj   +1 more source

Genomic analysis of three African strains of Bacillus anthracis demonstrates that they are part of the clonal expansion of an exclusively pathogenic bacterium

New Microbes and New Infections, 2014
Bacillus anthracis is the causative agent of anthrax and is classified as a ‘Category A’ biological weapon. Six complete genomes of B. anthracis (A0248, Ames, Ames Ancestor, CDC684, H0491, and Sterne) are currently available. In this report, we add three
L. Rouli, M. Mbengue, C. Robert, M. Ndiaye, B. La Scola, D. Raoult   +5 more
doaj   +1 more source

Pan-genome and core genome among Helicobacter pylori.

, 2016
(A) Histogram showing the distribution of the number of strains in each OG among the 30 strains. Sets of OGs corresponding to pan-genome, universal core, accessory, and unique OGs are indicated.
Ichizo Kobayashi (29889), Ikuo Uchiyama (14388), Koji Yahara (210105), Jacob Albritton (3141237), Masaki Fukuyo (3141240), Kenji K. Kojima (207564)   +5 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Table_1_PGAweb: A Web Server for Bacterial Pan-Genome Analysis.DOCX

, 2018
An astronomical increase in microbial genome data in recent years has led to strong demand for bioinformatic tools for pan-genome analysis within and across species.
Ming Yang (109148), Qian Liu (135614), Jun Yu (5904), Chen Sun (177008), Meili Chen (278448), Zhong Jin (1634215), Xinyu Chen (47670), Yongbing Zhao (134624), Jiayan Wu (204411), Jingfa Xiao (134638), Baohua Zhang (521406), Zhewen Zhang (786354), Yadong Zhang (13685), Jinyue Wang (4783629)   +13 more
core   +1 more source

3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species

Advanced Science, EarlyView.
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu, Chenhui Han, Cheng Xue, Manyi Sun, Bobo Song, Yongsong Xue, Guangyan Yang, Shaozhuo Xu, Wei Wei, Jiaming Li, Runze Wang, Jun Wu   +11 more
wiley   +1 more source

Data_Sheet_1_PGAweb: A Web Server for Bacterial Pan-Genome Analysis.PDF

, 2018
An astronomical increase in microbial genome data in recent years has led to strong demand for bioinformatic tools for pan-genome analysis within and across species.
Ming Yang (109148), Qian Liu (135614), Jun Yu (5904), Chen Sun (177008), Meili Chen (278448), Zhong Jin (1634215), Xinyu Chen (47670), Yongbing Zhao (134624), Jiayan Wu (204411), Jingfa Xiao (134638), Baohua Zhang (521406), Zhewen Zhang (786354), Yadong Zhang (13685), Jinyue Wang (4783629)   +13 more
core   +1 more source