Results 91 to 100 of about 174,716 (299)

Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies

mSystems, 2020
Salmonella is responsible for many nontyphoidal foodborne infections and enteric (typhoid) fever in humans. Of the two Salmonella species, Salmonella enterica is highly diverse and includes 10 known subspecies and approximately 2,600 serotypes ...
Cooper J. Park, Cheryl P. Andam
doaj   +1 more source

Sea Urchin‐Inspired Immuno‐Instructive Ionic Flow Drives MSCs‐Macrophage Communication to Promote Bone Regeneration

Advanced Materials, EarlyView.
ABSTRACT Bone tissue regeneration is a complex physiological process dependent on the spatiotemporal coordination of immune cells and stem cells. Conventional research primarily elucidates the mechanism through which materials facilitate bone formation by initially modulating macrophages and subsequently encouraging the osteogenic differentiation of ...
Yang Lu, Kun Su, Daqian Liu, Chunyu Liu, Muyan Qin, Shuaijie Li, Pengfei Tian, Yansong Wang, Yingbo Wang, Lei Chu, Xu Cui, Haobo Pan   +11 more
wiley   +1 more source

Application of Comparative Genomics for the Development of PCR Primers for the Detection of Harmful or Beneficial Microorganisms in Food: Mini-Review

Foods
Gene markers are widely utilized for detecting harmful and beneficial microorganisms in food products. Primer sequences targeting the 16S rRNA region, recognized as a conserved region, have been conventionally employed in PCR analyses.
Sang-Soon Kim
doaj   +1 more source

Genomic fluidity: an integrative view of gene diversity within microbial populations

BMC Genomics, 2011
Background The dual concepts of pan and core genomes have been widely adopted as means to assess the distribution of gene families within microbial species and genera.
Bergman Nicholas H, Haegeman Bart, Kislyuk Andrey O, Weitz Joshua S   +3 more
doaj   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Unveiling intraspecific diversity and evolutionary dynamics of the foodborne pathogen Bacillus paranthracis through high-quality pan-genome analysis

Current Research in Food Science
Understanding the evolutionary dynamics of foodborne pathogens throughout host-associated habitats is of utmost importance. Bacterial pan-genomes, as dynamic entities, are strongly influenced by ecological lifestyles.
Yuhui Du, Chengqian Qian, Xianxin Li, Xinqian Zheng, Shoucong Huang, Zhiqiu Yin, Tingjian Chen, Li Pan   +7 more
doaj   +1 more source

HUPAN: a pan-genome analysis pipeline for human genomes

Genome Biology, 2019
The human reference genome is still incomplete, especially for those population-specific or individual-specific regions, which may have important functions. Here, we developed a HUman Pan-genome ANalysis (HUPAN) system to build the human pan-genome.
Zhongqu Duan, Yuyang Qiao, Jinyuan Lu, Huimin Lu, Wenmin Zhang, Fazhe Yan, Chen Sun, Zhiqiang Hu, Zhen Zhang, Guichao Li, Hongzhuan Chen, Zhen Xiang, Zhenggang Zhu, Hongyu Zhao, Yingyan Yu, Chaochun Wei   +15 more
doaj   +1 more source

Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation

BMC Genomics, 2020
Background In bacteria, pan-genomes are the result of an evolutionary “tug of war” between selection and horizontal gene transfer (HGT). High rates of HGT increase the genetic pool and the effective population size (N e ), resulting in open pan-genomes ...
Mirna Vázquez-Rosas-Landa, Gabriel Yaxal Ponce-Soto, Jonás A. Aguirre-Liguori, Shalabh Thakur, Enrique Scheinvar, Josué Barrera-Redondo, Enrique Ibarra-Laclette, David S. Guttman, Luis E. Eguiarte, Valeria Souza   +9 more
doaj   +1 more source

Statistics of shared components in complex component systems [PDF]

, 2018
Many complex systems are modular. Such systems can be represented as "component systems", i.e., sets of elementary components, such as LEGO bricks in LEGO sets.
Caselle, Michele, Gherardi, Marco, Lagomarsino, Marco Cosentino, Mazzolini, Andrea, Osella, Matteo   +4 more
core   +4 more sources

Towards comparative pan-genomics

, 2020
Comparative genomics investigates the genomic makeup of species to unravel their unique variations and evolutionary relationships. High-throughput sequencing technologies have enabled reading the DNA content of a wide variety of species at an unprecedented rate.
openaire   +2 more sources