Results 71 to 80 of about 171,414 (293)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies

mSystems, 2020
Salmonella is responsible for many nontyphoidal foodborne infections and enteric (typhoid) fever in humans. Of the two Salmonella species, Salmonella enterica is highly diverse and includes 10 known subspecies and approximately 2,600 serotypes ...
Cooper J. Park, Cheryl P. Andam
doaj   +3 more sources

Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains.

PLoS ONE
Corynebacterium glutamicum is a non-pathogenic species of the Corynebacteriaceae family. It has been broadly used in industrial biotechnology for the production of valuable products.
Md Shahedur Rahman, Md Ebrahim Khalil Shimul, Md Anowar Khasru Parvez   +2 more
doaj   +1 more source

Pan-genome development of C. pseudotuberculosis.

, 2013
Center chart, the pan-genome development using permutations of all 15 strains of C. pseudotuberculosis; upper-right chart, the pan-genome development of the C. pseudotuberculosis biovar ovis strains; lower-right chart, the pan-genome development of the C.
Rommel Ramos (104515), Flávia Aburjaile (104527), Artur Silva (104505), Karina K. F. Nascimento (104529), Fernanda A. Dorella (104526), Luís C. Guimarães (104530), Eudes G. V. Barbosa (104524), Syeda M. Bakhtiar (104533), Vinicius A. C. Abreu (104540), Maria P. C. Schneider (104546), Anne C. Pinto (104520), Sintia Almeida (104531), Anderson R. Santos (104519), Anderson Miyoshi (104554), Amjad Ali (51075), Flávia S. Rocha (104528), Vasco Azevedo (104560), Ulisses P. Pereira (104536), Syed S. Hassan (104532), Eva Trost (104509), Adriana Carneiro (104518), Jochen Blom (104512), Carlos Diniz (104522), Siomar C. Soares (104501), Andreas Tauch (14870)   +24 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Characterizing the metabolism of Dehalococcoides with a constraint-based model. [PDF]

PLoS Computational Biology, 2010
Dehalococcoides strains respire a wide variety of chloro-organic compounds and are important for the bioremediation of toxic, persistent, carcinogenic, and ubiquitous ground water pollutants.
M Ahsanul Islam, Elizabeth A Edwards, Radhakrishnan Mahadevan   +2 more
doaj   +1 more source

Pan genome analysis of six Paracoccus type strains.

, 2023
Pan genome analysis of six Paracoccus type strains.
Thorsten Brinkhoff (385125), Anja Poehlein (113372), Rolf Daniel (113374), Jacqueline Hollensteiner (712771), Dominik Schneider (419981)   +4 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

seq-seq-pan: building a computational pan-genome data structure on whole genome alignment

BMC Genomics, 2018
Background The increasing application of next generation sequencing technologies has led to the availability of thousands of reference genomes, often providing multiple genomes for the same or closely related species.
Christine Jandrasits, Piotr W. Dabrowski, Stephan Fuchs, Bernhard Y. Renard   +3 more
doaj   +1 more source

Pan-genome development of C. bovis.

, 2018
Pan-genome development using permutations of all 21 isolates of C. bovis (left); the pan-genome development of the C. bovis isolates obtained from humans and cows (upper right); and, the pan-genome development of the C.
Aaron Villarma (5537420), Ben W. Humrighouse (5537408), Neil S. Lipman (6157028), John R. McQuiston (3694264), Christopher A. Gulvik (116648), Melissa E. Bell (3694240), Christopher Cheleuitte-Nieves (6157022), Vincent A. Fischetti (57436), Lars F. Westblade (6157025)   +8 more
core   +1 more source