Results 61 to 70 of about 1,691,339 (303)

Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability

open access: yesBMC Genomics, 2019
Background Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components that quickly help bacteria acquire large fragments of ...
Dekang Zhu   +16 more
doaj   +1 more source

Pangenome analysis of Corynebacterium striatum: insights into a neglected multidrug-resistant pathogen

open access: yesBMC Microbiology, 2023
Background Over the past two decades, Corynebacterium striatum has been increasingly isolated from clinical cultures with most isolates showing increased antimicrobial resistance (AMR) to last resort agents.
Wedad M. Nageeb, Helal F. Hetta
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Geobacillus Pan-Genome: Implications for the Evolution of the Genus [PDF]

open access: yesFrontiers in Microbiology, 2016
The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. Although the mechanisms underlying the thermophilicity of the organism and the thermostability of its macromolecules are reasonably well ...
Bezuidt, Keoagile Ignatius Oliver   +6 more
openaire   +4 more sources

Distributed hybrid-indexing of compressed pan-genomes for scalable and fast sequence alignment.

open access: yesPLoS ONE, 2021
Computational pan-genomics utilizes information from multiple individual genomes in large-scale comparative analysis. Genetic variation between case-controls, ethnic groups, or species can be discovered thoroughly using pan-genomes of such subpopulations.
Altti Ilari Maarala   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies

open access: yesmSystems, 2020
Salmonella is responsible for many nontyphoidal foodborne infections and enteric (typhoid) fever in humans. Of the two Salmonella species, Salmonella enterica is highly diverse and includes 10 known subspecies and approximately 2,600 serotypes ...
Cooper J. Park, Cheryl P. Andam
doaj   +3 more sources

Pan-genomics of polyploid crops: from complexity to breeding

open access: yesFrontiers in Plant Science
Improving crop productivity is essential to ensure global food security in the context of climate change and an increasing global population. Over the past few decades, sequencing has significantly expanded our ability to explore complex genomes. However,
Yogesh Dashrath Naik   +5 more
doaj   +1 more source

The Capsaspora genome reveals a complex unicellular prehistory of animals [PDF]

open access: yes, 2013
To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported
Chen, Zehua   +19 more
core   +1 more source

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