Results 61 to 70 of about 171,414 (293)
Frontiers in Plant SciencePan-genome studies are important for understanding plant evolution and guiding the breeding of crops by containing all genomic diversity of a certain species.
Meiye Jiang +11 more
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BMC Genomics, 2019 Background Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components that quickly help bacteria acquire large fragments of ...
Dekang Zhu +16 more
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Distributed hybrid-indexing of compressed pan-genomes for scalable and fast sequence alignment.
PLoS ONE, 2021 Computational pan-genomics utilizes information from multiple individual genomes in large-scale comparative analysis. Genetic variation between case-controls, ethnic groups, or species can be discovered thoroughly using pan-genomes of such subpopulations.
Altti Ilari Maarala +4 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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The Geobacillus Pan-Genome: Implications for the Evolution of the Genus [PDF]
Frontiers in Microbiology, 2016 The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. Although the mechanisms underlying the thermophilicity of the organism and the thermostability of its macromolecules are reasonably well ...
Bezuidt, Keoagile Ignatius Oliver +6 more
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The cyanobacterial core and pan-genome.
, 2018 (A) The distribution of CLOGs as a function of the number of assigned strains. (B) The size of the pan-genome estimated for an increasing number of strains.
Ralf Steuer (56833) +2 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Pan-genomics of polyploid crops: from complexity to breeding
Frontiers in Plant ScienceImproving crop productivity is essential to ensure global food security in the context of climate change and an increasing global population. Over the past few decades, sequencing has significantly expanded our ability to explore complex genomes. However,
Yogesh Dashrath Naik +5 more
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, 2018 Klebsiella pneumoniae pan-genome analysis files and Python script.These data are described in Wyres et al "Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae."
KELLY WYRES (1122371)
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Pan-genome mapping thresholds.
, 2023 a) Determining the number of additional genes identified at each CV threshold. The dashed red line indicates the chosen threshold (≤ 1.5) for the analysis. b) Distribution of mean gene coverages for the mapping of the ancient B.
Valentina Giuffra (4735104) +13 more
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