Results 81 to 90 of about 171,414 (293)

Erratum to: ‘Consensus pan-genome assembly of the specialised wine bacterium Oenococcus oeni’ [PDF]

, 2016
Background\ud \ud Oenococcus oeni is a lactic acid bacterium that is specialised for growth in the ecological niche of wine, where it is noted for its ability to perform the secondary, malolactic fermentation that is often required for many types of wine.
Peter R. Sternes, Anthony R. Borneman, Sternes, Peter R., Borneman, Anthony R.   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion.

PLoS Genetics, 2017
The human Y-chromosome does not recombine across its male-specific part and is therefore an excellent marker of human migrations. It also plays an important role in male fertility.
Laurits Skov, Danish Pan Genome Consortium, Mikkel Heide Schierup   +2 more
doaj   +1 more source

Pan-genome of Serratia spp.

, 2012
Euler diagram displaying the number of clusters found on each subspace of the pan-genome. The pan-genome defined here as the total collection of CDS clusters found in S. symbiotica SCc, S. symbiotica SAp, S. proteamaculans 568, S.
Andrés Moya (2203084), Alejandro Manzano-Marín (128471), Araceli Lamelas (128475), Amparo Latorre (88013)   +3 more
core   +1 more source

Glucose Deprivation‐Driven Concurrent Induction of Apoptosis/Disulfidptosis/Ferroptosis by Tumor Targeting Nanoassemblies in Triple‐Negative Breast Cancer Therapy

Advanced Functional Materials, EarlyView.
Innovative hybrid nanoassemblies installed with ferrocene, D‐α‐tocopherol succinate, and phloretin exploit the metabolic vulnerability of triple‐negative breast cancer under glucose starvation. By blocking glucose uptake, this single nanoplatform simultaneously orchestrates apoptosis, disulfidptosis, and ferroptosis to achieve synergistic and ...
Song Yi Lee, ChaeRim Hwang, Seong Eun Kim, Mrinmoy Karmakar, Seo Jin Jung, Hyeonseok Jang, Hae‐In Kim, Heejung Yang, Junmin Lee, Dae‐Duk Kim, Hyun‐Jong Cho   +10 more
wiley   +1 more source

Comparative Genome Analysis Reveals the Molecular Basis of Niche Adaptation of Staphylococcus epidermidis Strains

Frontiers in Genetics, 2020
Staphylococcus epidermidis is one of the most commonly isolated species from human skin and the second leading cause of bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic ...
Fei Su, Rui Tian, Yi Yang, Hexin Li, Gaoyuan Sun, Ying Li, Bingqing Han, Xiaomao Xu, Xue Chen, Gang Zhao, Hongyuan Cui, Hongtao Xu   +11 more
doaj   +1 more source

BPGA- an ultra-fast pan-genome analysis pipeline [PDF]

, 2016
Recent advances in ultra-high-throughput sequencing technology and metagenomics have led to a paradigm shift in microbial genomics from few genome comparisons to large-scale pan-genome studies at different scales of phylogenetic resolution.
Gupta, Vinod Kumar, Chaudhari, Narendrakumar M, Dutta, Chitra   +2 more
core   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

Pan-genome data for the genes in "Prediction of antibiotic resistance in Escherichia coli from large-scale pan-genome data"

, 2018
The pan-genome data for the paper under review.
Moradigaravand, D (via Mendeley Data)
core   +2 more sources