Results 81 to 90 of about 1,691,339 (303)

Analysis of 62 hybrid assembled human Y chromosomes exposes rapid structural changes and high rates of gene conversion.

PLoS Genetics, 2017
The human Y-chromosome does not recombine across its male-specific part and is therefore an excellent marker of human migrations. It also plays an important role in male fertility.
Laurits Skov, Danish Pan Genome Consortium, Mikkel Heide Schierup   +2 more
doaj   +1 more source

Characterizing the metabolism of Dehalococcoides with a constraint-based model. [PDF]

PLoS Computational Biology, 2010
Dehalococcoides strains respire a wide variety of chloro-organic compounds and are important for the bioremediation of toxic, persistent, carcinogenic, and ubiquitous ground water pollutants.
M Ahsanul Islam, Elizabeth A Edwards, Radhakrishnan Mahadevan   +2 more
doaj   +1 more source

Pan-genome analysis of 11 Sulfurospirillum genomes.

, 2016
Pan-genome matrix partitioned into core, soft core, shell, and cloud components (core = all 11 species, soft core = ≥ 10, shell = 3–9, and cloud = ≤ 2).
Daniel E. Ross (356500), R. Sean Norman (1952944), Harold D. May (645095), Christopher W. Marshall (645094)   +3 more
core   +1 more source

Pan-genome structure and function of type strains of Nocardia.

, 2021
(A) Gene accumulation curves for the pan-genome. (B) Gene accumulation curves for the core genome. The cumulative sizes of the pan-genome and core genome were calculated by type strains without replacement in random order 1000 times and then used to ...
Zhenpeng Li (553533), Shihong Fan (11337994), Zhenjun Li (275953), Shuai Xu (147659), Dan Li (106345), Yanlin Che (10185919), Xuexin Hou (436464), Yuanming Huang (6275378), Lichao Han (9959336)   +8 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains.

PLoS ONE
Corynebacterium glutamicum is a non-pathogenic species of the Corynebacteriaceae family. It has been broadly used in industrial biotechnology for the production of valuable products.
Md Shahedur Rahman, Md Ebrahim Khalil Shimul, Md Anowar Khasru Parvez   +2 more
doaj   +1 more source

Comparative Genome Analysis Reveals the Molecular Basis of Niche Adaptation of Staphylococcus epidermidis Strains

Frontiers in Genetics, 2020
Staphylococcus epidermidis is one of the most commonly isolated species from human skin and the second leading cause of bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic ...
Fei Su, Rui Tian, Yi Yang, Hexin Li, Gaoyuan Sun, Ying Li, Bingqing Han, Xiaomao Xu, Xue Chen, Gang Zhao, Hongyuan Cui, Hongtao Xu   +11 more
doaj   +1 more source

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-   +10 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source