Results 41 to 50 of about 113,177 (334)

Pancreas transplants

Clinical Radiology, 2009
Cadaveric, whole pancreas transplantation has proved an effective therapy in the treatment of long-standing type 1 diabetes mellitus and is capable of achieving an insulin-independent eugyclaemic state. As a result, this procedure is being increasingly performed. However, the surgical procedure is complex and unfamiliar to many radiologists.
Chandra, J, Phillips, R, Boardman, P, Gleeson, F, Anderson, E   +4 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

C-reactive protein (CRP) promotes malignant properties in pancreatic neuroendocrine neoplasms

Endocrine Connections, 2019
Objective: Elevated pre-operative C-reactive protein (CRP) serum values have been reported to be associated with poor overall survival for patients with pancreatic neuroendocrine neoplasms (pNEN).
Simon Schimmack, Yongchao Yang, Klaus Felix, Markus Herbst, Yixiong Li, Miriam Schenk, Frank Bergmann, Thilo Hackert, Oliver Strobel   +8 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients [PDF]

, 1999
Objective: The effect of donor bone marrow was evaluated for its potentially favorable effect in the authors' simultaneous pancreas/kidney transplant program.
Abdul S. Rao, Carlos A. Vivas, Corry, Corry, Corry, Corry, Corry, Egidi, Fioretto, Fontes, Greussner, Gruessner, Igor Dvorchik, John J. Fung, Jordan, Kapur, Mark L. Jordan, Nghiem, Pinna, Pradip K. Chakrabarti, Rao, Robert J. Corry, Ron Shapiro, Scantlebury, Shapiro, Sollinger, Starzl, Starzl, Starzl, Sugitani, Thomas E. Starzl, Tyden, Tyden, Velma P. Scantlebury, Wakely, Zehr   +35 more
core   +2 more sources

Simultaneous Pancreas-Kidney and Pancreas Transplantation [PDF]

Journal of the American Society of Nephrology, 2001
The discovery of insulin in 1922 changed the treatment of type 1 diabetes mellitus (DM) forever. Insulin was the first effective therapy for type 1 DM; however, its success engendered a terrible paradox for patients with this disease.
Bryan N, Becker, Jon S, Odorico, Yolanda T, Becker, Marilyn, Groshek, Cathy, Werwinski, John D, Pirsch, Hans W, Sollinger   +6 more
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy [PDF]

, 2023
Joana Ferrer, Benoît Mesnard, Franka Messner, Jason B. Doppenberg, Cinthia B. Drachenberg, Marten A. Engelse, Paul Johnson, Henri G. D. Leuvenink, Gabriel C. Oniscu, Vassilios Papalois, Rutger J. Ploeg, Trevor Reichman, William E. Scott, Fabio Vistoli, Thierry Berney, Daniel Jacobs‐Tulleneers‐Thevissen, Nicos Kessaris, Annemarie Weißenbacher, Ann Etohan Ogbemudia, Steve White, Julien Branchereau   +20 more
openalex   +1 more source