Results 201 to 210 of about 5,871,156 (346)

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

PIEZO1 enhances pancreatic cancer neurotropism. [PDF]

Cancer Cell Int
Li J, Liu Q, Xu R, Tang J, Wang L, Zheng Y, Weng S, Gao F.   +7 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

Nature Reviews Clinical Oncology, 2020
W. J. Ho, E. Jaffee, Lei Zheng
semanticscholar   +1 more source

Pancreatic cancer

Current Problems in Surgery, 1999
C J, Yeo, J L, Cameron
openaire   +2 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Pancreatic cancer-associated myofibroblasts: a review. [PDF]

Int J Biol Sci
Banacki M, Inkielewicz-Stepniak I.
europepmc   +1 more source

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Nature, 2015
S. Melo, L. B. Luecke, Christoph Kahlert, A. Fernández, S. Gammon, Judith Kaye, Valerie S. LeBleu, E. Mittendorf, J. Weitz, N. Rahbari, C. Reissfelder, C. Pilarsky, M. Fraga, D. Piwnica-Worms, R. Kalluri   +14 more
semanticscholar   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Transcriptomic Plasticity Is a Hallmark of Metastatic Pancreatic Cancer. [PDF]

Cancer Res
Jiménez-Sánchez A, Persad S, Hayashi A, Umeda S, Sharma R, Xie Y, Mehta A, Park W, Masilionis I, Chu T, Zhu F, Hong J, Chaligne R, O'Reilly EM, Mazutis L, Nawy T, Pe'er I, Iacobuzio-Donahue CA, Pe'er D.   +18 more
europepmc   +1 more source