Results 221 to 230 of about 5,871,156 (346)

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Atypical Lung Metastases From Pancreatic Cancer. [PDF]

Respirol Case Rep
Sato R, Fukuda Y, Ishida T.
europepmc   +1 more source

Targeting m6A Reader YTHDF1 Enhances Antitumor Immunity and Potentiates Anti‐PD‐L1 Efficacy in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
The m6A reader YTHDF1 drives intrahepatic cholangiocarcinoma (ICC) progression by remodeling the tumor immune microenvironment. YTHDF1 promotes MDSC recruitment via activation of m6A‐FOSL2‐CXCL6/CXCR2 axis, thereby suppressing CD8+ T cell infiltration and function.
Li Luo, Ziqin Liu, Zimin Song, Dong Zhang, Cong Liang, Fei Fang, Kai Lei, Lina Wang, Weikang Chen, Shunli Shen, Ming Kuang, Xiaoxing Li, Jun Yu, Shiyan Wang, Lixia Xu   +14 more
wiley   +1 more source

A KLF5's domino effect drives metastatic pancreatic cancer. [PDF]

Mol Cancer
Pena Ruiz NM, Fernandez-Zapico ME.
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Decoding the microbial blueprint of pancreatic cancer. [PDF]

Front Med (Lausanne)
Bautista J, Bedón-Galarza R, Martínez-Hidalgo F, Masache-Cruz M, Benítez-Núñez M, Valencia-Arroyo C, López-Cortés A.   +6 more
europepmc   +1 more source

Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer

Nature Cancer, 2020
N. Steele, Eileen S. Carpenter, Samantha B. Kemp, Veerin R. Sirihorachai, Stephanie The, L. Delrosario, J. Lazarus, E. Amir, Valerie Gunchick, Carlos E Espinoza, S. Bell, Lindsey Harris, Fatima Lima, Valerie M. Irizarry-Negron, Danielle Paglia, Justin Macchia, Angel Ka Yan Chu, Heather K. Schofield, Erik-Jan Wamsteker, Richard S. Kwon, Allison R. Schulman, A. Prabhu, R. Law, Arjun R. Sondhi, Jessica S. Yu, Arpan Patel, Katelyn L. Donahue, H. Nathan, C. Cho, Michelle A. Anderson, V. Sahai, C. Lyssiotis, W. Zou, Benjamin L. Allen, A. Rao, H. Crawford, Filip Bednar, T. Frankel, M. Pasca di Magliano   +38 more
semanticscholar   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Developments & Potential of Nanotechnology for the Detection and Treatment of Pancreatic Cancer. [PDF]

Int J Nanomedicine
O'Meara D, Hoskins C.
europepmc   +1 more source