Results 261 to 270 of about 413,940 (274)

Integrative insights into the role of CAV1 in ketogenic diet and ferroptosis in pancreatic cancer. [PDF]

Cell Death Discov
Liang X, Tian R, Li T, Wang H, Qin Y, Qian M, Fan J, Wang D, Cui HY, Jiang J.   +9 more
europepmc   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

Novel mRNA biomarker-based liquid biopsy for the detection of resectable pancreatic cancer. [PDF]

BMC Cancer
Lee JC, Kang SW, Sim EJ, Bae JS, Koo SM, Byoun MS, Kwon S, Hong S, Kim Y, Youn Y, Jung K, Kim J, Jeong HH, Kim J, Hwang JH.   +14 more
europepmc   +1 more source

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC) cells under high‐fat environment constrain harmful reactive oxygen species (ROS) by enhancing glutathione synthesis though upregulating interferon stimulated gene 15 (ISG15). In this process, upregulated high mobility group A1 (HMGA1) enhances ISG15 transcription, upregulated ISG15 subsequently noncovalently binds with ...
Xinran Liu, Qiujin Ma, Zhao Jia, Yihao Zhou, Churong Zou, Yushuo Xiao, Yuchen Chen, Chuyao Ma, Liangliang Song, Jing Yang, Chen Wang, Huidie Xu, Hong Chen, Jiajian Shi, Junqiu Yue, Yu Sun, Desheng Hu, Robert B Petersen, Yangkai Li, Anlin Peng, Kun Huang, Ling Zheng   +21 more
wiley   +1 more source

Unveiling the role of CXCL10 in pancreatic cancer progression: A novel prognostic indicator. [PDF]

Open Med (Wars)
Wu X, Rong L, Tang R, Li Q, Wang F, Deng X, Miao L.   +6 more
europepmc   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Enhancing diagnostic frameworks in pancreatic cancer imaging: A critical appraisal. [PDF]

World J Radiol
Dogru GD, Tugcu AO, Dursun CU.
europepmc   +1 more source

Exercise Guidelines in Pancreatic Cancer Based on the Dietz Model. [PDF]

Cancers (Basel)
Chang PJ, Hendifar AE, Gresham G, Ngo-Huang A, Oberstein PE, Parker N, Coveler AL.   +6 more
europepmc   +1 more source

Identification of USP39 as a prognostic and predictive biomarker for determining the response to immunotherapy in pancreatic cancer. [PDF]

BMC Cancer
Yuan J, Xu B, Su Y, Zhang P, Zhang X, Gong P.   +5 more
europepmc   +1 more source

The tandem duplicator phenotype may be a novel targetable subgroup in pancreatic cancer. [PDF]

NPJ Precis Oncol
Farooq AR, Zhang AX, Chan-Seng-Yue M, Topham JT, O'Kane GM, Jang GH, Fischer S, Dodd A, Holter S, Wilson J, Grant RC, Aung KL, Zogopoulos G, Elimova E, Prince R, Jang R, Moore M, Biagi J, Tang P, Goodwin R, Bathe OF, Marra M, Laskin J, Renouf DJ, Schaeffer DF, Karasinska JM, Notta F, Gallinger S, Knox JJ, Tsang ES.   +29 more
europepmc   +1 more source