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Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target [PDF]

Frontiers in Nutrition, 2022
Pancreatic-related disorders such as pancreatitis, pancreatic cancer, and type 1 diabetes mellitus (T1DM) impose a substantial challenge to human health and wellbeing. Even though our understanding of the initiation and progression of pancreatic diseases
Tao Zhang, Tao Zhang, Tao Zhang, Guangqi Gao, Guangqi Gao, Guangqi Gao, Hafiz Arbab Sakandar, Hafiz Arbab Sakandar, Hafiz Arbab Sakandar, Lai-Yu Kwok, Lai-Yu Kwok, Lai-Yu Kwok, Zhihong Sun, Zhihong Sun, Zhihong Sun   +14 more
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Case Report: Partial response to single-agent pembrolizumab in a chemotherapy-resistant metastatic pancreatic cancer patient with a high tumor mutation burden

Frontiers in Oncology, 2023
Single-agent immune checkpoint blockade has shown no clinical benefits in pancreatic cancer. Recently, the programmed cell death protein 1 (PD-1) antibody pembrolizumab has been recommended as a treatment option for high tumor mutational burden (TMB ...
Mengyao Dai, Mengyao Dai, Mengyao Dai, Mengyao Dai, Jianpeng Sheng, Jianpeng Sheng, Jianpeng Sheng, Qi Zhang, Qi Zhang, Qi Zhang, Qi Zhang, Jianxin Wang, Jianxin Wang, Jianxin Wang, Jianxin Wang, Qihan Fu, Qihan Fu, Qihan Fu, Qihan Fu, Tingbo Liang, Tingbo Liang, Tingbo Liang, Tingbo Liang   +22 more
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Positive feedback between lncRNA FLVCR1-AS1 and KLF10 may inhibit pancreatic cancer progression via the PTEN/AKT pathway

Journal of Experimental & Clinical Cancer Research, 2021
Background FLVCR1-AS1 is a key regulator of cancer progression. However, the biological functions and underlying molecular mechanisms of pancreatic cancer (PC) remain unknown.
Jiewei Lin, Shuyu Zhai, Siyi Zou, Zhiwei Xu, Jun Zhang, Lingxi Jiang, Xiaxing Deng, Hao Chen, Chenghong Peng, Jiaqiang Zhang, Baiyong Shen   +10 more
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A case of walled‐off necrosis extending into the pelvic cavity successfully treated by endoscopic necrosectomy using a lumen‐apposing metal stent

DEN Open, 2022
A 31‐year‐old man developed massive walled‐off necrosis extending into the pelvic cavity following severe acute alcoholic pancreatitis. Endoscopic ultrasound‐guided fistula drainage was performed using a lumen‐apposing metal stent, but this was ...
Makoto Morita, Tomoyuki Yokota, Ryo Yano, Michiko Amano, Hironori Ochi, Nobuaki Azemoto, Toshie Mashiba, Kouji Joko   +7 more
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LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma

Journal of Hematology & Oncology, 2022
Background LncRNA-PACERR plays critical role in the polarization of tissue-associated macrophages (TAMs). In this study, we found the function and molecular mechanism of PACERR in TAMs to regulate pancreatic ductal adenocarcinoma (PDAC) progression ...
Yihao Liu, Minmin Shi, Xingfeng He, Yizhi Cao, Pengyi Liu, Fanlu Li, Siyi Zou, Chenlei Wen, Qian Zhan, Zhiwei Xu, Jiancheng Wang, Baofa Sun, Baiyong Shen   +12 more
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Real‐world implications of nonbiological factors with staging, clinical management, and prognostic prediction in pancreatic ductal adenocarcinoma

Cancer Medicine, 2023
Background The American Joint Committee on Cancer (AJCC) tumor‐node‐metastasis (TNM) staging system focuses on traditional biological factors (BFs). The present study incorporates nonbiological factors (NBFs) into the AJCC‐TNM staging system in terms of ...
Chao Wang, Haoda Chen, Xiaxing Deng, Wei Xu, Baiyong Shen   +4 more
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Establishment of a 3D culture model in vitro of pancreatic cancer primary cells using hydrogel microspheres

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To establish an in vitro culture model mimicking tumor microenvironment using hydrogel microspheres and fresh primary pancreatic cancer cells.Methods·The morphological distribution of the hydrogel microspheres was recorded, observed and ...
MA Fangfang, QIN Jiejie, REN Lingjie, TANG Xiaomei, LIU Jia, SHI Minmin, JIANG Lingxi   +6 more
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Development and validation of a cancer stem cell-related signature for prognostic prediction in pancreatic ductal adenocarcinoma

Journal of Translational Medicine, 2020
Background Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic signatures based on CSC-related genes
Zengyu Feng, Minmin Shi, Kexian Li, Yang Ma, Lingxi Jiang, Hao Chen, Chenghong Peng   +6 more
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Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway

International Journal of Endocrinology, 2023
Purpose. This study aimed to investigate the potential mechanism underlying the therapeutic effect of sildenafil in combination with islet transplantation for diabetic peripheral neuropathy. Methods.
Xiandong Zhu, Shangjing Xie, Jiawei Chen, Qiaohong Lu, Xiaowu Wang, Feixiang Duan, Sinian Xu, Yan Zhang, Hongjian Huang, Yongqiang Wang, Hongwei Wang, Bicheng Chen, Huanjie Huang   +12 more
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RETRACTED ARTICLE: The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA

Journal of Hematology & Oncology, 2022
Background Although a substantial increase in the survival of patients with other cancers has been observed in recent decades, pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest diseases. No effective screening approach exists.
Zengyu Feng, Kexian Li, Kai Qin, Juyong Liang, Minmin Shi, Yang Ma, Shiwei Zhao, Huaiyu Liang, Dongni Han, Baiyong Shen, Chenghong Peng, Hao Chen, Lingxi Jiang   +12 more
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