Results 241 to 250 of about 471,297 (330)

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

The Role of Endoscopic Ultrasound-Guided Shear Wave Elastography in Pancreatic Diseases. [PDF]

Diagnostics (Basel)
Abboud Y, Gaddam S.
europepmc   +1 more source

PANCREATIC DISEASE.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996
D, MASTROJENI, S, CAMBRIA
openaire   +1 more source

Patterns of Disease Dissemination and Survival in Patients with Synchronous and Metachronous Metastatic Pancreatic Adenocarcinoma: Nationwide Population-Based Study

Merlijn U.J.E. Graus, Aniek E. van Diepen, Kim Josemanders, Marc G. Besselink, Stefan A.W. Bouwense, Lois A. Daamen, Ignace H. J. T. de Hingh, Evelien J.M. de Jong, Hanneke W.M. van Laarhoven, Vincent E. de Meijer, I. Quintus Molenaar, Martijn W.J. Stommel, Liselot Valkenburg‐van Iersel, Hanneke Wilmink, Lydia G. van der Geest, Judith de Vos‐Geelen   +15 more
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases. [PDF]

Int J Mol Sci
Ryu S, Lee EK.
europepmc   +1 more source

Prognostic factors for disease-free survival in patients with pancreatic ductal adenocarcinoma after surgery: a single center experience

, 2019
Xiaodong Tian, Jisong Li, Hongqiao Gao, Yan Zhuang, Yongsu Ma, Yiran Chen, Xuehai Xie, Yinmo Yang   +7 more
openalex   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study. [PDF]

Front Nutr
Lin L, Huang Y, Qian S, Chen L, Sun H.
europepmc   +1 more source

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source