Results 271 to 280 of about 433,719 (316)

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Pro-Inflammatory Food, Gut Microbiota, and Cardiovascular and Pancreatic Diseases. [PDF]

Biomolecules
Chen B, Patel S, Bao L, Nadeem D, Krittanawong C.   +4 more
europepmc   +1 more source

Signifiance of autoimmune reactions to pancreatic juice in Crohn´s disease [PDF]

, 1988
Goebell, Harald, Malchow, H., Otte, M., Peskar, B. M., Scriba, Peter Christian, Stöcker, W.   +5 more
core   +1 more source

133. Evaluation of Incremental Dynamic-CT (ID-CT) for pancreatic disease

, 1991
村上 正広, 千葉 亮一, 黒田 洋明, 奥 正巳   +3 more
openalex   +2 more sources

Morphologic and morphometric evaluation of pancreatic islets in chronic Chagas' disease [PDF]

, 2001
João Carlos Saldanha, Vitorino Modesto dos Santos, Marlene Antônia dos Reis, Daniel Ferreira da Cunha, Vicente de Paula Antunes Teixeira   +4 more
openalex   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives. [PDF]

World J Gastroenterol
Bi YW, Li LS, Ru N, Zhang B, Lei X.
europepmc   +1 more source

The clinical significance of PIVKA-II determination in patients with hepatic, biliary and pancreatic diseases.

, 1990
Masato Sakon, Morito Monden, Mitsukazu Gotoh, Toshio Kanai, K Umeshita, W Endoh, Takesada Mori   +6 more
openalex   +2 more sources

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source

Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study. [PDF]

J Clin Med
Vilà-Quintana L, Fort E, Pardo L, Albiol-Quer MT, Ortiz MR, Capdevila M, Feliu A, Bahí A, Llirós M, Aguilar E, García-Velasco A, Ginestà MM, Laquente B, Pozas D, Lluansí A, Pimenoff VN, Moreno V, Garcia-Gil LJ, Duell EJ, Carreras-Torres R, Aldeguer X.   +20 more
europepmc   +1 more source