Results 111 to 120 of about 231,974 (295)
The Lancet Oncology, 2020 Pancreatic ductal adenocarcinoma is the seventh leading cause of cancer death worldwide with an estimated 432 242 deaths occurring in 2018. This estimate, in conjunction with the findings that pancreatic ductal adenocarcinoma incidence is rising and that
Eric S. Christenson, E. Jaffee, N. Azad
semanticscholar +1 more source
Macrophages and pancreatic ductal adenocarcinoma [PDF]
Cancer Letters, 2016 Monocytes and macrophages make up part of the innate immune system and provide one of the first defenses against variety of treats. Macrophages can also modulate the adaptive immune system. Efficient sensing and response to tissue environmental cues highlights the complexity and dynamic nature of macrophages and their plasticity.
Habtezion, Aida +2 more
openaire +4 more sources
Significance of frailty in prognosis after surgery in patients with pancreatic ductal adenocarcinoma
World Journal of Surgical Oncology, 2021 Background Frailty is an important consideration for older patients undergoing surgery. We aimed to investigate whether frailty could be a prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent pancreatic resection. Methods One
Shinichiro Yamada +8 more
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Metabolic Dependencies in Pancreatic Cancer. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R. +3 more
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Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis. [PDF]
, 2015 Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic and inflammatory microenvironment that is formed primarily by activated, myofibroblast-like, stellate cells.
Dhall, Deepti +4 more
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Frontiers in OncologyBackgroundThe ubiquitin proteasome system is involved in the regulation of cellular gene transcription and cellular receptor function through the degradation of proteins, thus affecting tumorigenesis and development.
Yan-Hui Yang +10 more
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Molecular Cancer, 2018 Background Defective autophagy is thought to contribute to the pathogenesis of many diseases, including cancer. Human plasmacytoma variant translocation 1 (PVT1) is an oncogenic long non-coding RNA that has been identified as a prognostic biomarker in ...
Fengting Huang +9 more
doaj +1 more source
Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies.
Chang, Hui-Hua +10 more
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Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance We describe here the most comprehensive analyses of extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) yet available, which detected previously unknown molecular changes during PDAC progression in both mouse models and ...
Chenxi Tian +9 more
semanticscholar +1 more source
PLoS ONE, 2021 Background/objectivesPancreatic ductal adenocarcinoma is a highly lethal disease with increasing incidence. Due to high resistance, chemo/radiotherapy has limited success in pancreatic cancer and only marginally prolongs patient survival.
Sarah Peisl +5 more
doaj +1 more source