Results 101 to 110 of about 433,923 (290)
Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You +10 morewiley +1 more sourceThe predictors and patterns of the early recurrence of pancreatic ductal adenocarcinoma after pancreatectomy: the influence of pre- and post- operative adjuvant therapy
BMC Surgery, 2019 Background The perioperative factors predicting or influencing early pancreatic ductal adenocarcinoma recurrence are unclear. This study attempted to identify the predictive factors for early pancreatic ductal adenocarcinoma recurrence post ...Hironobu Suto, Keiichi Okano, Minoru Oshima, Yasuhisa Ando, Shigeo Takahashi, Toru Shibata, Hideki Kamada, Hideki Kobara, Tsutomu Masaki, Yasuyuki Suzuki +9 moredoaj +1 more sourceThe deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma [PDF]
, 2012 Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four signature somatic mutations(1-4) in addition to numerous lower frequency genetic events of ...Brosnan, J.A., Knight, S., Cloonan, N, Aust, D., Largaespada, DA, Patch, AM, Perez-Mancera, Pedro, Ralph H Hruban, Li, A., J Lynn Fink, Taylor, D, Anthony J Gill, Silverstein, K.A.T., Grimmond, S. M., Lodewyk F. A. Wessels, Xu, C, Patrick Martin, David K Chang, De Ridder, J, Nigel A Spry, Biankin, Andrew V, Morgan, R., Nagrial, Adnan, Venessa T Chin, Wessels, L.F.A., Kevin A. T. Silverstein, de Ridder J, Rümmele P, Rust, A.G., Aust, DE, Pilarsky, C., Aust, Daniela, Wood, S.A., Ridder, Jeroen de, Biankin, A. V., Derek L. Stemple, Biankin, AVW, Simpson, SL, Knosel, T., Rusta, Alistair, John Chen, Chou, A, Yu J, Musgrove, EA, Ralph H. Hruban, van der Weyden, L., Tuveson DA, Merrett, Neil D. (R14270), Grimond, SM, Ann-Marie Patch, Nicole Cloonan, Chin, VT, Chang, David K, Skye L Simpson, Chang DK, Mark J Cowley, Chelsie O'Connor, Ivon Harliwong, Biankin, Andrew V., Goggins, Michael, Cindy Forrest, Wessels, L, Kynan Feeney, Grutzmann, R, van der Weyden, Louise, Klein, AP, Nagrial, AM, Perez-Mancera, P, Mo Ballal, Tamara Debrencini, Tuveson, DA, Ismail, K, Kristiansen, G, Largaespada, D.A., Darrin Taylor, Kristiansen, Glen, Rust, Alistair G, Ray Asghari, Matthew Anderson, Rust, AG, Idrisoglu, S, Samra, JS, Hruban, RH, Guminski, A, David J. Adams, Spencer Knight, Stemple, DL, Mona Martyn-Smith, Silverstein, KAT, Yu, J., Caroline L Cooper, Nones, K, Tuveson, D.A., Wessels LF, Hruban, R, Jones, MD, Waddell, N, Jaswinder S Samra, Ming Chai, Li, A., Louise van der Weyden, Roger J Daly, et al., Pinese, M, Chou, Angela ; https://orcid.org/, Chang, D, Knight, Spencer, Holmes, O, Cosman, Peter, Morgan, R., ten Hoeve, J. J., Allen Li, Thomas Knösel, Wessels, Lodewyk F. A., Virginia James, Stefania Beghelli, Lynn Fink, J, Herd C, Margaret A Tempero, de Ridder, J., Jianmin Wu, Daly, Roger ; https://orcid.org/, Christine A. Iacobuzio-Donahue, Kasim Ismail, David Joseph, Chang, David K., Collier LS, Robert L Sutherland, Ang Li, Pilarsky C, Jun Yu, Pérez-Mancera PA, Rümmele, P., Gongora, M, Krishna P Epari, Merrett, Neil, Asghari, R, Wilson, PJ, Rummele, Petra, Christopher J Scarlett, other, and, Tim Bruxner, Wessels, Lodewyk FA, Brosnan JA, Jeremy L Humphris, Grutzmann, Robert, Glen Kristiansen, Aust D, Christopher Christophi, Richard A Morgan, Mark Pinese, Grützmann, R., Largaespada, D. A., Pearson, JV, Adams, David J, Karin S Kassahn, Chantrill, LA, Li, Allen, Sanjay Mukhedkar, Shinn Yeung, Ten Hoeve, JJ, Aust, D., Angela Chou, Jacqueline A. Brosnan, Kettleborough, R., Adnan M Nagrial, Michael Texler, Mehrdad Nikfarjam, Silverstein, K. A., James R Eshleman, David K Miller, Andrew V. Biankin, Elizabeth A Musgrove, Rust, A. G., Amber L Johns, Iacobuzio-Donahue, C.A., Daniela Aust, Grimmond, SM, O'Connor, C, Hruban, Ralph H., Sarver, A. L., Knight S, Sean M. Grimmond, Ehsan Nourbakhsh, Lorraine A Chantrill, Charbel Sandroussi, Pajic, M, Katia Nones, Chang, D. K., Angelika Christ, Pilarsky, CP, Grützmann R, Jessica Pettit, Adams, DJ, Wu, J, Biankin, AV, Kaplan, Warren, Pérez-Mancera, P.A., Herd, C, Anderson, M, Alison P. Klein, Tuveson, David A., Wood SA, Herd, C., Knight, S, Pavey, Darren, Collaborators Australian Pancreatic Cancer Genome Initiative: Andrew V Biankin, Senel Idrisoglu, Yu, J, Biankin AV, Knosel, T, Largaespada DA, Sarver, Aaron L., Merrett, ND, de Ridder, J., Klein, A. P., Rowe, SJ, Wu, Jianmin, de Ridder, Jeroen, Blankin, AV, Gill, AJ, Musgrove, Elizabeth, Humphris, JL, Wessels, LFA, David A. Largaespada, James G Kench, R Scott Mead, Kettleborough, R, Andrew Laycock, Toon, Christopher Chien Wei ; https://orcid.org/, Sarver, Aaron L, Pedro A. Pérez-Mancera, Andrew P Barbour, Australian Pancreatic Cancer Genome Initiative, Chuan P Tan, John V Pearson, Petra Rümmele, Christian Pilarsky, Rummele, P., ten Hoeve, Jelle J, Martyn-Smith, M, Adams, D.J., Ruemmele, Petra, Pilarsky, C, Anirban Maitra, Wood, S. A., Nourbakhsh, E, Knösel, T., Chang, D.K., van der Weyden L, Christina Xu, Bastiaan DeBoer, Vincenzo Corbo, Gill, Anthony, Knight, S., ten Hoeve, J.J., Michael Hatzifotis, Collier, LS, Rooman, Ilse, Grimmond, S, Iacobuzio-Donahue CA, Johns, Amber, Lara S. Collier, Amanda Mawson, Oliver Holmes, Nourse, C, Ross Kettleborough, Rooman, I, Richard, G Morgan, Bruxner, T, Kellee Slater, Toon, C, Kristiansen, G., Jelle J. ten Hoeve, Stemple, D.L., Maria Scardoni, Nam Q Nguyen, Nicola Waddell, Wood, Stephen A, Kettleborough R, Andrew D Clouston, David K. Chang, Rust AG, Iacobuzio-Donahue, C. A., Wood, Stephen, Hoeve, Jelle J. ten, Pavlakis, N, Newell, F, Aaron L. Sarver, Stegeman, S, Cowley, Mark ; https://orcid.org/, David R Fletcher, Song, S, Silverstein, Kevin AT, Bienkin, AV, Li, Ang, Goggins M, Pajic, Marina, Adams DJ, Neil D Merrett, Li A, Largaespada, David A, Brosnan, JA, Adams, David J., Richard D Schulick, Henry C Pleass, Collier, L.S., Richard Morgan, Kristiansen, GO, Knoesel, Thomas, Henry Tang, Michael Goggins, Wood, S, Pavey, DA, Sarah J Rowe, Daly, RJ, Knosel, Thomas, Andrew V Blankin, Kristiansen, G., Wessels, L. F., ten Hoeve JJ, Grimmond SM, Scott Wood, Brosnan, J. A., Amy Chiang, Sutherland, RL, Harliwong, I, Miller, DK, Yu, Jun, Peter H Cosman, Knight, Richard, Stegeman, S., Peter J Wilson, Christopher Toon, Sarver, AL, Sarver AL, Cowley, MJ, Adams, D. J., Manning, S, van der Weyden, L., Shane Stegeman, Klein, A.P., Rita T Lawlor, Chantrill, Lorraine ; https://orcid.org/, asghari, Ray, Pilarsky, Christian, Weyden, Louise van der, Pilarsky, C., Alistair G. Rust, Sutherland, Robert, Milena Gongora, Jonathan W Fawcet, Virginia Papangelis, Li, A, Stephen A. Wood, Klein, Alison P., Biankin, A.V., Tuveson, David A, Sean M Grimmond, Klein AP, Suzanne Manning, Thomas J O'Rourke, Perez-Mancera, P. A., Christ, A, Stegeman, Shane, Rust, Alistair G., Kassahn, KS, Warren Kaplan, Hruban, R. H., Shivangi Wani, Leonard, C, Knösel T, Herd, C., Mawson, A, Goggins, M., Kettleborough, Ross, Sarver, A.L., Felicity Newell, Wani, S, Cheng, DK, Mary-Anne L Brancato, Grimmond, Sean M, Stemple, D, Stegeman, S., Colin Herd, Goggins, M, Christine A Iacobuzio-Donahue, Rummele, P, Collier, L. S., Klein, Alison P, Iacobuzio-Donahue, Christine A, Nick Pavlakis, Amitabha Das, Chris Worthley, Grimmond, S.M., Wood, SA, Johns, AL, Stemple, Derek L., Stemple, Derek L, Hruban, Ralph H, Peter Hodgkinson, Stemple, D. L., Laycock Crawford, Pettit, J, Herd, Colin, Marc D Jones, Robert Grützmann, Collier, Lara S., David A. Tuveson, Brosnan, Jacqueline A., Das, A, Ridder, Jeroen, Silverstein, Kevin, van der Weyden, L, Iacobuzio-Donahue, Christine A., Kristiansen G, Brancato, MAL, Marina Pajic, Iacobuzio-donahue, CA, Claudio Bassi, Maria Beilin, Chang, DK, Stemple DL, Scott Mead, R, Hruban RH, Brosnan, Jacqueline A, Jeroen de Ridder, Gruetzmann, Robert, Collier, Lara S, Nikolajs Zeps, Yu, J., Stegeman S, Alex Guminski, Silverstein, Kevin A. T., Kettleborough, R., Cosman, PH, Perez-Mancera, Pedro A., Andrew R Ruszkiewicz, Largaespada, David A., Duncan McLeod, Pérez-Mancera, PA, Conrad Leonard, Hruban, R.H., Morgan, Richard, Aust, D, Perez-Mancera, Pedro A, Ilse Rooman, Chang, David, Wood, Stephen A., Goggins, M., Christopher L Wolfgang, Grutzmann, R., Tuveson, D. A., Vincent W Lam, Mawson, Amanda, Sarah Song, Craig Nourse, Klein, A, Aldo Scarpa, Mark E Brooke-Smith, Darren A Pavey, Sarver, Aaron, Morgan, R, Grimmond, Sean M., ten Hoeve, Jelle J., Silverstein KA, Morgan R, Rust, A., Stemple, D., Perez-Mancera, P., Brosnan, J., Sarver, A., Silverstein, K. +472 morecore +1 more sourceFrom Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits
Advanced Science, EarlyView.This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao +5 morewiley +1 more sourceInhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma [PDF]
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original author and source are ...Wang, X, Jing Chen, Fan Yan, Xin, W, He Ren, Yan, F, Qian, D, Li, J, Hao, J, Wen Xin, Dong Qian, Chongbiao Huang, Jia, L, Song Gao, Jing Li, Chen, J, Huang, C, Zhao, T, Ren, H, Gao, S, Li Jia, Jihui Hao, Tiansuo Zhao, Xiuchao Wang +23 morecore +1 more sourceDeubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
Advanced Science, EarlyView.Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao +13 morewiley +1 more sourceGlycolytic heterogeneity drives metabolic-targeted therapy in pancreatic ductal adenocarcinoma
Signal Transduction and Targeted TherapyPancreatic ductal adenocarcinoma is traditionally characterized as a glycolytic tumor. However, the extent and clinical relevance of its metabolic heterogeneity remain poorly understood.Ugo Chianese, Chiara Papulino, Gerardo Saggese, Ahmad Ali, Marianna Ciotola, Enza Lonardo, Mirko Cortese, Gregorio Favale, Annabella Di Mauro, Danila La Gioia, Valentina Golino, Eduardo Sommella, Pietro Campiglia, Renato Franco, Fortunato Ciardiello, Ferdinando De Vita, Vincenzo Carafa, Lucia Altucci, Rosaria Benedetti +18 moredoaj +1 more sourceDiscovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers
Advanced Science, EarlyView.AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang +21 morewiley +1 more source
