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Inhibition of HIF-1 alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
, 2015 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original author and source are ...Wang, X, Jing Chen, Fan Yan, Xin, W, He Ren, Yan, F, Qian, D, Li, J, Hao, J, Wen Xin, Dong Qian, Chongbiao Huang, Jia, L, Song Gao, Jing Li, Chen, J, Huang, C, Zhao, T, Ren, H, Gao, S, Li Jia, Jihui Hao, Tiansuo Zhao, Xiuchao Wang +23 morecore +1 more sourceThe deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
, 2012 Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four signature somatic mutations(1-4) in addition to numerous lower frequency genetic events of ...Brosnan, J.A., Knight, S., Cloonan, N, Aust, D., Largaespada, DA, Patch, AM, Perez-Mancera, Pedro, Ralph H Hruban, Li, A., J Lynn Fink, Taylor, D, Anthony J Gill, Silverstein, K.A.T., Grimmond, S. M., Lodewyk F. A. Wessels, Xu, C, Patrick Martin, David K Chang, De Ridder, J, Nigel A Spry, Biankin, Andrew V, Morgan, R., Nagrial, Adnan, Venessa T Chin, Wessels, L.F.A., Kevin A. T. Silverstein, de Ridder J, Rümmele P, Rust, A.G., Aust, DE, Pilarsky, C., Aust, Daniela, Wood, S.A., Ridder, Jeroen de, Biankin, A. V., Derek L. Stemple, Biankin, AVW, Simpson, SL, Knosel, T., Rusta, Alistair, John Chen, Chou, A, Yu J, Musgrove, EA, Ralph H. Hruban, van der Weyden, L., Tuveson DA, Merrett, Neil D. (R14270), Grimond, SM, Ann-Marie Patch, Nicole Cloonan, Chin, VT, Chang, David K, Skye L Simpson, Chang DK, Mark J Cowley, Chelsie O'Connor, Ivon Harliwong, Biankin, Andrew V., Goggins, Michael, Cindy Forrest, Wessels, L, Kynan Feeney, Grutzmann, R, van der Weyden, Louise, Klein, AP, Nagrial, AM, Perez-Mancera, P, Mo Ballal, Tamara Debrencini, Tuveson, DA, Ismail, K, Kristiansen, G, Largaespada, D.A., Darrin Taylor, Kristiansen, Glen, Rust, Alistair G, Ray Asghari, Matthew Anderson, Rust, AG, Idrisoglu, S, Samra, JS, Hruban, RH, Guminski, A, David J. Adams, Spencer Knight, Stemple, DL, Mona Martyn-Smith, Silverstein, KAT, Yu, J., Caroline L Cooper, Nones, K, Tuveson, D.A., Wessels LF, Hruban, R, Jones, MD, Waddell, N, Jaswinder S Samra, Ming Chai, Li, A., Louise van der Weyden, Roger J Daly, et al., Pinese, M, Chou, Angela ; https://orcid.org/, Chang, D, Knight, Spencer, Holmes, O, Cosman, Peter, Morgan, R., ten Hoeve, J. J., Allen Li, Thomas Knösel, Wessels, Lodewyk F. A., Virginia James, Stefania Beghelli, Lynn Fink, J, Herd C, Margaret A Tempero, de Ridder, J., Jianmin Wu, Daly, Roger ; https://orcid.org/, Christine A. Iacobuzio-Donahue, Kasim Ismail, David Joseph, Chang, David K., Collier LS, Robert L Sutherland, Ang Li, Pilarsky C, Jun Yu, Pérez-Mancera PA, Rümmele, P., Gongora, M, Krishna P Epari, Merrett, Neil, Asghari, R, Wilson, PJ, Rummele, Petra, Christopher J Scarlett, other, and, Tim Bruxner, Wessels, Lodewyk FA, Brosnan JA, Jeremy L Humphris, Grutzmann, Robert, Glen Kristiansen, Aust D, Christopher Christophi, Richard A Morgan, Mark Pinese, Grützmann, R., Largaespada, D. A., Pearson, JV, Adams, David J, Karin S Kassahn, Chantrill, LA, Li, Allen, Sanjay Mukhedkar, Shinn Yeung, Ten Hoeve, JJ, Aust, D., Angela Chou, Jacqueline A. Brosnan, Kettleborough, R., Adnan M Nagrial, Michael Texler, Mehrdad Nikfarjam, Silverstein, K. A., James R Eshleman, David K Miller, Andrew V. Biankin, Elizabeth A Musgrove, Rust, A. G., Amber L Johns, Iacobuzio-Donahue, C.A., Daniela Aust, Grimmond, SM, O'Connor, C, Hruban, Ralph H., Sarver, A. L., Knight S, Sean M. Grimmond, Ehsan Nourbakhsh, Lorraine A Chantrill, Charbel Sandroussi, Pajic, M, Katia Nones, Chang, D. K., Angelika Christ, Pilarsky, CP, Grützmann R, Jessica Pettit, Adams, DJ, Wu, J, Biankin, AV, Kaplan, Warren, Pérez-Mancera, P.A., Herd, C, Anderson, M, Alison P. Klein, Tuveson, David A., Wood SA, Herd, C., Knight, S, Pavey, Darren, Collaborators Australian Pancreatic Cancer Genome Initiative: Andrew V Biankin, Senel Idrisoglu, Yu, J, Biankin AV, Knosel, T, Largaespada DA, Sarver, Aaron L., Merrett, ND, de Ridder, J., Klein, A. P., Rowe, SJ, Wu, Jianmin, de Ridder, Jeroen, Blankin, AV, Gill, AJ, Musgrove, Elizabeth, Humphris, JL, Wessels, LFA, David A. Largaespada, James G Kench, R Scott Mead, Kettleborough, R, Andrew Laycock, Toon, Christopher Chien Wei ; https://orcid.org/, Sarver, Aaron L, Pedro A. Pérez-Mancera, Andrew P Barbour, Australian Pancreatic Cancer Genome Initiative, Chuan P Tan, John V Pearson, Petra Rümmele, Christian Pilarsky, Rummele, P., ten Hoeve, Jelle J, Martyn-Smith, M, Adams, D.J., Ruemmele, Petra, Pilarsky, C, Anirban Maitra, Wood, S. A., Nourbakhsh, E, Knösel, T., Chang, D.K., van der Weyden L, Christina Xu, Bastiaan DeBoer, Vincenzo Corbo, Gill, Anthony, Knight, S., ten Hoeve, J.J., Michael Hatzifotis, Collier, LS, Rooman, Ilse, Grimmond, S, Iacobuzio-Donahue CA, Johns, Amber, Lara S. Collier, Amanda Mawson, Oliver Holmes, Nourse, C, Ross Kettleborough, Rooman, I, Richard, G Morgan, Bruxner, T, Kellee Slater, Toon, C, Kristiansen, G., Jelle J. ten Hoeve, Stemple, D.L., Maria Scardoni, Nam Q Nguyen, Nicola Waddell, Wood, Stephen A, Kettleborough R, Andrew D Clouston, David K. Chang, Rust AG, Iacobuzio-Donahue, C. A., Wood, Stephen, Hoeve, Jelle J. ten, Pavlakis, N, Newell, F, Aaron L. Sarver, Stegeman, S, Cowley, Mark ; https://orcid.org/, David R Fletcher, Song, S, Silverstein, Kevin AT, Bienkin, AV, Li, Ang, Goggins M, Pajic, Marina, Adams DJ, Neil D Merrett, Li A, Largaespada, David A, Brosnan, JA, Adams, David J., Richard D Schulick, Henry C Pleass, Collier, L.S., Richard Morgan, Kristiansen, GO, Knoesel, Thomas, Henry Tang, Michael Goggins, Wood, S, Pavey, DA, Sarah J Rowe, Daly, RJ, Knosel, Thomas, Andrew V Blankin, Kristiansen, G., Wessels, L. F., ten Hoeve JJ, Grimmond SM, Scott Wood, Brosnan, J. A., Amy Chiang, Sutherland, RL, Harliwong, I, Miller, DK, Yu, Jun, Peter H Cosman, Knight, Richard, Stegeman, S., Peter J Wilson, Christopher Toon, Sarver, AL, Sarver AL, Cowley, MJ, Adams, D. J., Manning, S, van der Weyden, L., Shane Stegeman, Klein, A.P., Rita T Lawlor, Chantrill, Lorraine ; https://orcid.org/, asghari, Ray, Pilarsky, Christian, Weyden, Louise van der, Pilarsky, C., Alistair G. Rust, Sutherland, Robert, Milena Gongora, Jonathan W Fawcet, Virginia Papangelis, Li, A, Stephen A. Wood, Klein, Alison P., Biankin, A.V., Tuveson, David A, Sean M Grimmond, Klein AP, Suzanne Manning, Thomas J O'Rourke, Perez-Mancera, P. A., Christ, A, Stegeman, Shane, Rust, Alistair G., Kassahn, KS, Warren Kaplan, Hruban, R. H., Shivangi Wani, Leonard, C, Knösel T, Herd, C., Mawson, A, Goggins, M., Kettleborough, Ross, Sarver, A.L., Felicity Newell, Wani, S, Cheng, DK, Mary-Anne L Brancato, Grimmond, Sean M, Stemple, D, Stegeman, S., Colin Herd, Goggins, M, Christine A Iacobuzio-Donahue, Rummele, P, Collier, L. S., Klein, Alison P, Iacobuzio-Donahue, Christine A, Nick Pavlakis, Amitabha Das, Chris Worthley, Grimmond, S.M., Wood, SA, Johns, AL, Stemple, Derek L., Stemple, Derek L, Hruban, Ralph H, Peter Hodgkinson, Stemple, D. L., Laycock Crawford, Pettit, J, Herd, Colin, Marc D Jones, Robert Grützmann, Collier, Lara S., David A. Tuveson, Brosnan, Jacqueline A., Das, A, Ridder, Jeroen, Silverstein, Kevin, van der Weyden, L, Iacobuzio-Donahue, Christine A., Kristiansen G, Brancato, MAL, Marina Pajic, Iacobuzio-donahue, CA, Claudio Bassi, Maria Beilin, Chang, DK, Stemple DL, Scott Mead, R, Hruban RH, Brosnan, Jacqueline A, Jeroen de Ridder, Gruetzmann, Robert, Collier, Lara S, Nikolajs Zeps, Yu, J., Stegeman S, Alex Guminski, Silverstein, Kevin A. T., Kettleborough, R., Cosman, PH, Perez-Mancera, Pedro A., Andrew R Ruszkiewicz, Largaespada, David A., Duncan McLeod, Pérez-Mancera, PA, Conrad Leonard, Hruban, R.H., Morgan, Richard, Aust, D, Perez-Mancera, Pedro A, Ilse Rooman, Chang, David, Wood, Stephen A., Goggins, M., Christopher L Wolfgang, Grutzmann, R., Tuveson, D. A., Vincent W Lam, Mawson, Amanda, Sarah Song, Craig Nourse, Klein, A, Aldo Scarpa, Mark E Brooke-Smith, Darren A Pavey, Sarver, Aaron, Morgan, R, Grimmond, Sean M., ten Hoeve, Jelle J., Silverstein KA, Morgan R +466 morecore +1 more sourceInhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis
Advanced Science, EarlyView.FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang +11 morewiley +1 more sourceDiffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models
European Journal of Radiology Open, 2016 Objectives: To compare two Gaussian diffusion-weighted MRI (DWI) models including mono-exponential and bi-exponential, with the non-Gaussian kurtosis model in patients with pancreatic ductal adenocarcinoma.Nikolaos Kartalis, Georgios C. Manikis, Louiza Loizou, Nils Albiin, Frank G. Zöllner, Marco Del Chiaro, Kostas Marias, Nikolaos Papanikolaou +7 moredoaj +1 more sourcePhotodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo
Advanced Science, EarlyView.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan +7 morewiley +1 more sourceTargeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunity
Nature CommunicationsPancreatic ductal adenocarcinoma remains one of the most formidable challenges in oncology, with limited treatment options and a poor prognosis. Understanding the key pathways affecting cancer progression is crucial for the development of therapeutic ...Panzhu Bai, Chengmin Liu, Changying Fu, Renwei Cai, Yanyan Ding, Meiling Quan, Yuhao Ye, Ziyang Zhang, Yuan Li, Yanfen Xu, Siqi Guo, Binbin Li, Guizhen Li, Wudi Yu, Dalu Wang, Ming Jiang, Yi Deng, Sicong He, Chuanyue Wu, Ruijun Tian, Ying Sun +20 moredoaj +1 more sourceDiminishing calcifications as a potential predictor of pancreatic ductal adenocarcinoma arising in association with IPMN in patients with chronic pancreatitis
Radiology Case ReportsChronic pancreatitis (CP) is a progressive benign fibroinflammatory condition involving repeated episodes of pancreatic inflammation, which lead to fibrotic tissue replacement and subsequent pancreatic insufficiency.Mohammad Yasrab, MD, Ryan C. Rizk, MS, Felipe Lopez-Ramirez, MD, Taha M. Ahmed, MD, Alejandra Blanco, MD, Ammar A. Javed, MD, Linda C. Chu, MD, Elliot K. Fishman, MD, Satomi Kawamoto, MD +8 moredoaj +1 more source
