Results 131 to 140 of about 84,228 (303)

Cardiac conduction system involvement in metastatic pancreatic ductal adenocarcinoma [PDF]

, 2005
While almost all malignant tumors are occasionally found to have metastasized to the heart, the involvement of the heart is not common and is poorly studied.
L. Matturri, G.Ottaviani
core  

microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma

, 2018
We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC).
Leandro Castellano, Castellano, Leandro, Ottaviani, S, Silvia Ottaviani   +3 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Clinicopathological features of pancreatic ductal adenocarcinoma patients.

, 2016
Clinicopathological features of pancreatic ductal adenocarcinoma patients.
Sean Davis (15957), Paul S. Meltzer (143970), Yaroslav Teper (2560042), Joshua J. Waterfall (2560036), Udo Rudloff (2560027), Holger Pflicke (2560024), Sandra Sczerba Burkett (2560030), Satyajit Ray (255274), Marbin Pineda (2560045), Matt R. McCord (2560033), Rebecca Sorber (564202), J. Keith Killian (143964), Abisola Abisoye-Ogunniyan (2560039)   +12 more
core   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Novel machine‐learning model for predicting lymph node metastasis in resectable pancreatic ductal adenocarcinoma

Annals of Gastroenterological Surgery
Aim Lymph node metastasis is an adverse prognostic factor in pancreatic ductal adenocarcinoma. However, it remains a challenge to predict lymph node metastasis using preoperative imaging alone.
Susumu Daibo, Yuki Homma, Hiroki Ohya, Hironori Fukuoka, Kentaro Miyake, Mayumi Ozawa, Takafumi Kumamoto, Ryusei Matsuyama, Yusuke Saigusa, Itaru Endo   +9 more
doaj   +1 more source

Synchronous Pancreatic Ductal Adenocarcinomas Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Biopsy

Gut and Liver, 2015
Cases of pancreatic ductal adenocarcinoma with multiple masses accompanying underlying pancreatic diseases, such as intraductal papillary mucinous neoplasm, have been reported.
doaj   +1 more source

Photodynamic therapy for cancer of the pancreas

, 2002
Background: Few pancreatic cancers are suitable for surgery and few respond to chemoradiation. Photodynamic therapy produces local necrosis of tissue with light after prior administration of a photosensitising agent, and in experimental studies can be ...
Lovat, L.B., Hatfield, A.W.R., Rogowska, A.Z., Wyld, P., Gillams, A., Jones, L., Bown, S.G., Ripley, P., Whitelaw, D.E., Lees, W.R.   +9 more
core  

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, EarlyView.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source