Results 151 to 160 of about 64,777 (328)

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Joint Shape Representation and Classification for Detecting PDAC [PDF]

arXiv, 2018
We aim to detect pancreatic ductal adenocarcinoma (PDAC) in abdominal CT scans, which sheds light on early diagnosis of pancreatic cancer. This is a 3D volume classification task with little training data. We propose a two-stage framework, which first segments the pancreas into a binary mask, then compresses the mask into a shape vector and performs ...
arxiv  

CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy

Advanced Science, EarlyView.
CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan, Shiying Li, Mengbo Wang, Shuai Cheng Li   +3 more
wiley   +1 more source

FusionNet: Incorporating Shape and Texture for Abnormality Detection in 3D Abdominal CT Scans [PDF]

arXiv, 2019
Automatic abnormality detection in abdominal CT scans can help doctors improve the accuracy and efficiency in diagnosis. In this paper we aim at detecting pancreatic ductal adenocarcinoma (PDAC), the most common pancreatic cancer. Taking the fact that the existence of tumor can affect both the shape and the texture of pancreas, we design a system to ...
arxiv  

Overexpression of Midkine in Pancreatic Duct Adenocarcinomas Induced by N‐Nitrosobis(2‐oxopropyl)amine in Hamsters and Their Cell Lines [PDF]

, 2000
Masahiro Tsutsumi, Kenji Kadomatsu, Toshifumi Tsujiuchi, Hiroyuki Sakitani, Shinya Ikematsu, Tadahiko Kubozoe, Masatoshi Yoshimoto, Takashi Muramatsu, Sadatoshi Sakuma, Yoichi Konishi   +9 more
openalex   +1 more source

Interventional Nanotheranostics of Pancreatic Ductal Adenocarcinoma

Theranostics, 2016
Pancreatic ductal adenocarcinoma (PDAC) accounts for over 90% of all pancreatic cancer. Nanoparticles (NPs) offer new opportunities for image-guided therapy owing to the unique physicochemical properties of the nanoscale effect and the multifunctional capabilities of NPs. However, major obstacles exist for NP-mediated cancer theranostics, especially in
Junjie Li, Chun Li, Sanjay Gupta, Fengyong Liu   +3 more
openaire   +2 more sources

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

AI-assisted Early Detection of Pancreatic Ductal Adenocarcinoma on Contrast-enhanced CT [PDF]

arXiv
Pancreatic ductal adenocarcinoma (PDAC) is one of the most common and aggressive types of pancreatic cancer. However, due to the lack of early and disease-specific symptoms, most patients with PDAC are diagnosed at an advanced disease stage. Consequently, early PDAC detection is crucial for improving patients' quality of life and expanding treatment ...
arxiv  

Positive intraoperative peritoneal lavage cytology is a negative prognostic factor in pancreatic ductal adenocarcinoma: a retrospective single-center study

Frontiers in Oncology, 2015
Objective: The aim of this study is to evaluate the prognostic significance of intraoperative peritoneal lavage cytology (PLC) in pancreatic invasive ductal adenocarcinoma.Methods: Intraoperative PLC was evaluated in 162 patients with resectable ...
Kenichi eHirabayashi, Akiko eImoto, Misuzu eYamada, Atsuko eHadano, Nabuaki eKato, Youko eMiyajima, Hitoshi eIto, Yoshiaki eKawaguchi, Toshio eNakagohri, Tetsuya eMine, Naoya eNakamura   +10 more
doaj   +1 more source