Results 191 to 200 of about 64,777 (328)

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Technical recommendation on multiplex MR elastography for tomographic mapping of abdominal stiffness with a focus on the pancreas and pancreatic ductal adenocarcinoma [PDF]

arXiv
Objectives: MR elastography (MRE) offers valuable mechanical tissue characterization, however, in deep abdominal organs like the pancreas conventional single-driver, single-frequency approaches often fail. This study evaluates whether multiplex MRE using multiple drivers and vibration frequencies can overcome these limitations.
arxiv  

Pancreatic ductal adenocarcinoma

, 2012
Eric P. Tamm, Gauri R. Varadhachary, Jason B. Fleming   +2 more
openaire   +3 more sources

The K‐ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium

, 1999
Jütta Lüttges, B. Schlehe, Martin A. O. H. Menke, Ilka Vogel, Doris Henne‐Bruns, Günter Klöppel   +5 more
openalex   +1 more source

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform [PDF]

, 2005
Markus Kosmahl, Ursula Pauser, Martin Anlauf, Günter Klöppel   +3 more
openalex   +1 more source

Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer. [PDF]

, 2019
BackgroundTreatment outcomes for patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain dismal. There are unmet needs for understanding the biologic basis of this malignancy using novel next-generation sequencing technologies.
Fanta, Paul, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Okamura, Ryosuke, Patel, Charmi, Patel, Hitendra, Raymond, Victoria M   +7 more
core   +1 more source

Associations of body mass index and waist circumference with incidence of overall and of 27 site‐specific cancers: a population‐based retrospective cohort study

Cancer Communications, EarlyView.
Abstract Background Overweight and obesity are known risk factors for cancer. The aim of this study was to investigate associations of body mass index (BMI) and waist circumference (WC) with incidence of 27 site‐specific cancers stratified by sex and menopausal status accounting for non‐linearity.
Seonghye Kim, Bongseong Kim, Kyu‐won Jung, Ga Eun Nam, Wonyoung Jung, Junhee Park, Kyung‐Do Han, Dong Wook Shin   +7 more
wiley   +1 more source

Emerging concepts in the management of pancreatic ductal adenocarcinoma

Laparoscopic, Endoscopic and Robotic Surgery, 2019
Pancreatic ductal adenocarcinoma is characterised by poor oncological outcomes with curative treatment only possible for a minority. Symptoms are dependent on the stage of the disease and location within the pancreas with constitutional decline often ...
Sanket Srinivasa, Rowan Parks
doaj  

K-Ras-Independent Effects of the Farnesyl Transferase Inhibitor L-744,832 on Cyclin B1/Cdc2 Kinase Activity, G2/M Cell Cycle Progression and Apoptosis in Human Pancreatic Ductal Adenocarcinoma Cell

, 2000
Si Young Song, Ingrid M. Meszoely, Robert J. Coffey, Jennifer A. Pietenpo, Steven D. Leach   +4 more
openalex   +1 more source

Modified Appleby Procedure with Arterial Reconstruction for Locally Advanced Pancreatic Adenocarcinoma: A Literature Review and Report of Three Unusual Cases. [PDF]

, 2016
BACKGROUND: Pancreatic body and tail ductal adenocarcinomas are often diagnosed with local vascular invasion of the celiac axis (CA) and its various branches. With such involvement, these tumors have traditionally been considered unresectable.
Lamb, Kathleen M., Latona, Jessica A., Maley, Warren R., Pucci, Michael J., Yeo, Charles J.   +4 more
core   +1 more source