Results 231 to 240 of about 433,923 (290)

Dual Targeting of FGFR4 and PI3K-mTOR Suppresses Tumor-Associated Phenotypes in Pancreatic Ductal Adenocarcinoma. [PDF]

Int J Mol Sci
Goode JA, Harris SA, Altomare DA.
europepmc   +1 more source

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, EarlyView.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Granular cell tumor of the pancreas mimicking pancreatic ductal adenocarcinoma: a case report. [PDF]

BMC Gastroenterol
Béndek M, Pozzi-Mucelli R, Moro CF, Gilg S.   +3 more
europepmc   +1 more source

Daraxonrasib and Beyond: Pan‐RAS Inhibition, Resistance, and Next‐Generation Strategies

Cancer Science, EarlyView.
ABSTRACT RAS proteins have long been considered difficult therapeutic targets, but allele‐selective inhibitors established the clinical tractability of mutant RAS. Daraxonrasib (RMC‐6236), an oral pan‐RAS inhibitor, has now extended this concept by targeting multiple mutant and wild‐type RAS proteins.
Ryo Honda
wiley   +1 more source

R0 Resection improves survival after multivisceral resection for pancreatic ductal adenocarcinoma. [PDF]

iScience
Rebelo A, Andersson B, Bandyopadhyay SK, Bereza-Carlson P, Berrevoet F, Björnsson B, Bouwense S, Bergquist E, Bösch F, Büchler M, Chatzizacharias N, Coubeau L, Crede M, Pathirannehalage Don CB, Dries P, Erkan M, Felsenstein M, Frigerio I, Giardino A, Glowka T, Hadesi P, Hartman V, Johansen K, Klein M, Klose J, Knipper K, Leonhardt CS, Loos M, Malinka T, Marchegiani G, Månsson C, Pellegrini R, Perri G, Poelsler LH, Roeyen G, Rousek M, Sancho P, Schild-Suhren S, Schmidt T, Serrablo L, Serrablo A, Smith AM, Stavrou GA, Strobel O, Shrikhande S, Strobel A, Tarantino I, Urdzik J, Vilz T, Vella R, Wennerblom J, Wyzlic P, Kleeff J, Multivisceral Pancreatic Resections Research Group: A Collaboration of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA).   +53 more
europepmc   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Fingerprinting the Metabolic and Lipidomic Landscapes of Pancreatic Ductal Adenocarcinoma with MALDI Imaging. [PDF]

Clin Cancer Res
Yousf S, Glunde K, Brown DR, Tressler C, Solaiyappan M, Krishnamachary B, Mironchik Y, Dbouk M, Goggins MG, Bhujwalla ZM.   +9 more
europepmc   +1 more source

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source

Biomarker-driven immunotherapy and adoptive cell therapy in recurrent pancreatic ductal adenocarcinoma. [PDF]

Front Med (Lausanne)
He T, Li G, Qi F.
europepmc   +1 more source