Results 241 to 250 of about 217,476 (395)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

BARD1: A Friend or Foe in Pancreatic Ductal Adenocarcinoma? [PDF]

Int J Mol Sci
Zekavat L, Jain A.
europepmc   +1 more source

Licochalcone A suppresses pancreatic ductal adenocarcinoma progression by targeting eEF2K-mediated pyroptosis [PDF]

Junjie Peng, Hiutung Chan, Wenqing Chen, Ken Kin Lam Yung, King‐Ho Cheung, Zhu Zhang   +5 more
openalex   +1 more source

Neuronal Reshaping of the Tumor Microenvironment in Tumorigenesis and Metastasis: Bench to Clinic

Medicine Advances, EarlyView.
This graphical abstract illustrates the multidimensional crosstalk between neurons and tumor microenvironment as well as targeted intervention strategies identified in the study. It highlights three core interaction axes: nerve‐tumor crosstalk mediated by neurotransmitters and neurotrophic factors, neuro‐vascular communication driving angiogenesis via ...
Yimao Wu, Ruowei Sun, Shuai Ren, Gokhan Zengin, Mengyao Li   +4 more
wiley   +1 more source

Multiparametric MRI to Predict Response to Irreversible Electroporation Plus Anti‐PD‐1 Immunotherapy in Pancreatic Ductal Adenocarcinoma

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate contrast‐enhanced T1‐weighted MRI and diffusion‐weighted magnetic resonance imaging (DWI) for early prediction of tumor response to combined irreversible electroporation (IRE) and anti‐PD‐1 immunotherapy. Methods Murine pancreatic ductal adenocarcinoma (PDAC) cells KRAS* were inoculated into the pancreas of C57BL/6 mice.
Qizhen Cao, Mark D. Pagel, Charles V. Kingsley, Jingfei Ma, James P. Long, Xiaoxia Wen, Seth T. Gammon, Jorge Delacerda, Sanaz Javadi, Chun Li   +9 more
wiley   +1 more source

Quantification of Signal Transduction Pathway Activity in Pancreatic Ductal Adenocarcinoma. [PDF]

Int J Mol Sci
Raymakers L, Daamen LA, Intven MPW, Leusen JHW, Olofsen PA, van de Stolpe A, Raymakers RAP.   +6 more
europepmc   +1 more source

Sonoporation for Augmenting Chemotherapy of Pancreatic Ductal Adenocarcinoma

, 2019
Jason Castle, Spiros Kotopoulis, Flemming Forsberg   +2 more
openalex   +2 more sources

New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

Drugs, 2020
R. Singh, E. O’Reilly
semanticscholar   +1 more source

Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts†

The Journal of Pathology, EarlyView.
Abstract Pancreatic cystic lesions present a unique opportunity to identify and potentially prevent pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Until now, research has primarily focused on intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), whose potential for malignant transformation ...
Paolo Riccardo Camisa, Daniele Campa, Irene Esposito, Stefano Crippa   +3 more
wiley   +1 more source

Deconvolution Methods to Link Multi‐Omics Data to Cell Type‐Specific Extracellular Vesicle Abundances

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) provide non‐invasive information on cellular health and disease. Yet, with the small size of EVs and more than 200 cell types contributing EVs to the extracellular fluids, it is challenging to determine whether changes in EV‐associated lipids, RNAs, and proteins occur because of differences in expression or cell ...
Iben Skov Jensen, Jannik Hjortshøj Larsen, Per Svenningsen   +2 more
wiley   +1 more source