Results 281 to 290 of about 64,777 (328)

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, EarlyView.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Mast Cells in Tumor Microenvironment Promotes the In Vivo Growth of Pancreatic Ductal Adenocarcinoma

, 2011
David Z. Chang, Ying Ma, Baoan Ji, Huamin Wang, Defeng Deng, Yan Liu, James L. Abbruzzese, Yong‐Jun Liu, Craig D. Logsdon, Patrick Hwu   +9 more
openalex   +1 more source

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma [PDF]

, 2018
Belt, Brian A, Cullinan, Darren R, DeNardo, David G, Fields, Ryan C, Gillanders, William E, Goedegebuure, Peter, Han, Booyeon J, Hawkins, William G, Jacobs, Ryan C, Linehan, David C, Nywening, Timothy M, Panni, Roheena Z, Patel, Ankit A, Sanford, Dominic E, Ye, Jian   +14 more
core   +1 more source

GLP‐1 receptor agonists and the risk for cancer: A meta‐analysis of randomized controlled trials

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims To assess if there is a difference in the oncogenic risk between GLP‐1 RA and comparators in randomized controlled trials. Materials and Methods A meta‐analysis of randomized controlled trials comparing GLP‐1RA to any comparators for diabetes and/or obesity, lasting at least 52 weeks.
Giovanni Antonio Silverii, Christian Marinelli, Costanza Bettarini, Gloria Giovanna Del Vescovo, Matteo Monami, Edoardo Mannucci   +5 more
wiley   +1 more source

Total lesion glycolysis is a promising predictor of chemo‐response in pancreatic cancer patients treated with neoadjuvant chemotherapy prior to surgery

European Journal of Clinical Investigation, EarlyView.
Abstract Background There has been increased use of neoadjuvant chemotherapy (NAC) in resectable pancreatic ductal adenocarcinoma (PDAC) patients. [18F]fluoro‐2‐deoxyglucose positron emission tomography/computed tomography (FDG‐PET/CT) scan is being frequently used to determine treatment response in PDAC patients undergoing NAC.
Sooin Byeon, Bridget Abbott, Paul Roach, Dale L. Bailey, Angela Chou, Sarah Maloney, Anthony J. Gill, Jaswinder Samra, Anubhav Mittal, Sumit Sahni   +9 more
wiley   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, EarlyView.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Zic family member 5 promotes RIO kinase 3 expression to enhance pancreatic cancer survival

The FEBS Journal, EarlyView.
This study demonstrates that targeting ZIC5 increases gemcitabine sensitivity and induces pancreatic cancer shrinkage in vivo. The findings also show that ALDH3B1, PTGES, and TUFT1, the downstream genes of ZIC5, contribute to gemcitabine resistance in pancreatic cancer cells.
Reiko Satow, Yuki Kashiwaba, Misaki Okao, Shin Takano, Yuna Aiga, Atsuko Yoneda, Kazuyoshi Hosomichi, Kiyoko Fukami   +7 more
wiley   +1 more source

The Landscape of SPP1+ Macrophages Across Tissues and Diseases: A Comprehensive Review

Immunology, EarlyView.
SPP1+ macrophages represent a conserved, disease‐associated population present across cancerous and non‐cancerous conditions, involved in immunosuppression, fibrosis, lipid metabolism, phagocytosis, and other cellular processes. This review highlights their shared molecular programmes across tissues, their interactions with stromal and immune cells ...
Alessandro Palma
wiley   +1 more source

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

Immunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

Deucravacitinib in plaque psoriasis: Four‐year safety and efficacy results from the Phase 3 POETYK PSO‐1, PSO‐2 and long‐term extension trials

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this analysis of the long‐term safety and efficacy of deucravacitinib in patients with moderate to severe plaque psoriasis treated through 4 years, no new safety signals were observed compared with the first year. Patients continuously treated with deucravacitinib from Day 1 maintained clinical and patient‐reported outcome response rates.
April W. Armstrong, Mark Lebwohl, Richard B. Warren, Howard Sofen, Akimichi Morita, Carle Paul, Kim A. Papp, Matthew J. Colombo, Julie Scotto, John Vaile, Joe Zhuo, Eleni Vritzali, Victoria Berger, Georgene Schroeder, Subhashis Banerjee, Diamant Thaçi, Bruce Strober   +16 more
wiley   +1 more source