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Pancreatic Exocrine Insufficiency: Diagnostic Evaluation and Replacement Therapy with Pancreatic Enzymes

Digestive Diseases, 2010
In chronic pancreatitis over a course of years to decades, pancreatic parenchyma is gradually lost and pain is gradually decreasing as signs and symptoms of malabsorption appear. Appearance of calcifications is a late sign and in many cases coincides with appearance of steatorrhea. Decreasing output of insulin and glucagon results in diabetes mellitus,
openaire   +2 more sources

Pancreatic enzymes replacement therapy in chronic pancreatitis: an update.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 2002
Chronic pancreatitis is the major cause of exocrine pancreatic insufficiency which should be compensated by pancreatic enzyme replacement therapy. There are now available a great number of pancreatic enzyme preparations, but encapsulated enteric-coated microspheres and minimicrospheres are considered the enzyme treatment of choice.
A, Trifan, G, Balan, C, Stanciu
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Pancreatic enzyme replacement therapy in chronic pancreatitis: a long way to go

Gut, 2017
Pancreatic exocrine insufficiency (PEI) in chronic pancreatitis (CP) is underdiagnosed and undertreated. An important and expertly conducted meta-analysis in this issue examines the efficacy of pancreatic enzyme replacement therapy (PERT) in patients with CP.1 The key findings are that PERT increases fat and protein absorption and does so more ...
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Pancreatic enzyme replacement therapy (PERT) for malabsorption in patients with metastatic pancreatic cancer

BMJ Supportive & Palliative Care, 2014
PurposeThe diagnosis of metastatic pancreatic cancer (PC) carries a poor prognosis. PC is associated with weight loss and malabsorption in high rates secondary to pancreatic exocrine insufficiency. UK and USA guidelines exist recommending the empiric use of pancreatic enzyme replacement therapy (PERT) for quality of life in these patients.
Amanda, Landers   +2 more
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Pancreatic Enzyme Replacement Therapy Device (PERT-D)

2018
The pancreas is an important part of the endocrine system. When stimulated, by the brain when someone starts eating, the pancreas releases digestive enzymes into the small intestine. In people who have lost pancreatic function, such as those suffering from chronic pancreatitis, pancreatic enzyme replacement therapy (PERT) is a necessary treatment to ...
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The Role of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer

Pancreas, 2017
Although patients with pancreatic cancer (PC) are prone to exocrine pancreatic insufficiency, there are little evidence about pancreatic enzyme replacement therapy (PERT) in patients with PC, especially those receiving chemotherapy.This is a prospective consecutive observational study of PERT in patients with unresectable PC.
Tomotaka, Saito   +17 more
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Topics in Clinical Pharmacology: Pancreatic Enzyme Replacement Therapy

The American Journal of the Medical Sciences, 1989
A number of pancreatic enzyme replacement agents are currently available for correction of pancreatic insufficiency. All are derivatives of pancrelipase derived from hog pancreas and contain lipase, amylase, and protease. Pancrelipase preparations exist in two major forms.
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Pancreatic enzyme replacement therapy in post-pancreatectomy patients.

International journal of pancreatology : official journal of the International Association of Pancreatology, 1989
The occurrence of malnutrition and maldigestion was studied in nine patients who underwent pancreatoduodenectomy and sclerosis of the residual pancreatic stump with neoprene. The operation causes a complete loss of exocrine pancreatic function, but spares islet cell function.
Braga, M   +7 more
openaire   +4 more sources

Pancreatic enzyme-replacement therapy in CF: considerations for the USA

Expert Review of Respiratory Medicine, 2008
Pancreatic enzyme products (PEPs) have been commercially available since before the passage of the Food, Drug and Cosmetic Act in 1938. They are a vital therapy for patients with cystic fibrosis and exocrine pancreatic insufficiency. PEPs help to enhance absorption of nutrients and thereby play an important role in maintaining good nutritional status ...
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Radiation therapy‐associated toxicity: Etiology, management, and prevention

Ca-A Cancer Journal for Clinicians, 2021
Kyle Wang
exaly  

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